Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone
Polyoxyethylene glycols (PEG) are nontoxic substances, which ones do not irritate the skin, therefore can be used as pharmaceutical excipients to differentiate the properties of various matrices. The effect of variable content and molecular mass of PEG in cellulose acetate matrices on the testostero...
Gespeichert in:
| Veröffentlicht in: | Pharmazie 1991-10, Vol.46 (10), p.719-723 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 723 |
|---|---|
| container_issue | 10 |
| container_start_page | 719 |
| container_title | Pharmazie |
| container_volume | 46 |
| creator | CICHON, R JANICKI, S |
| description | Polyoxyethylene glycols (PEG) are nontoxic substances, which ones do not irritate the skin, therefore can be used as pharmaceutical excipients to differentiate the properties of various matrices. The effect of variable content and molecular mass of PEG in cellulose acetate matrices on the testosterone solubility, the rate of water sorption and the release rate of testosterone from the matrix model of TTS was studied. It may be concluded that the testosterone solubility in matrices, the rate of water sorption by systems and the pharmaceutical availability of drug can be regulated on a relatively wide scale independently of molecular mass by the amounts of PEGs incorporated into matrices. It was found that in all cases of triphase matrices the liberation process of terosterone was well correlated with Higuchi's equation. The rate of water sorption by PEG and matrices may be described by the equation Q = k square root of t. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72686338</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72686338</sourcerecordid><originalsourceid>FETCH-LOGICAL-p235t-641da1513d7cfe3fb0f87e9c908acfc440e3eee1f62e544f5f1175ede6e416603</originalsourceid><addsrcrecordid>eNo9kMFLwzAYxXtQ5pz-CUIOItuhkDRp2h1lzCkMFJznkqVfXCRtapLievYfN9Pi6YP3fjy-986SKcaUpAVh7CK59P4D44xnvJwkE1JiSstymnyvlQIZkFWos2awxwHCYTDQAno3g7TGo_nLerNAtkWdsx24oMGf8HAA1Ijg9BE1tgbzqznR-hpcI8zJd6KDPmiJ_OADNGi-270u0JcOBxTABxtFZ1u4Ss6VMB6uxztL3h7Wu9Vjun3ePK3ut2mX0TyknJFakJzQupAKqNpjVRawlEtcCqkkYxgoABDFM8gZU7kipMihBg6McI7pLLn7y41FPvv4QNVoL8EY0YLtfVXEbXicJYI3I9jvG6irzulGuKEaV4v-7egLL4VRsbXU_h_LM5pRtqQ_BbJ3Lw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72686338</pqid></control><display><type>article</type><title>Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CICHON, R ; JANICKI, S</creator><creatorcontrib>CICHON, R ; JANICKI, S</creatorcontrib><description>Polyoxyethylene glycols (PEG) are nontoxic substances, which ones do not irritate the skin, therefore can be used as pharmaceutical excipients to differentiate the properties of various matrices. The effect of variable content and molecular mass of PEG in cellulose acetate matrices on the testosterone solubility, the rate of water sorption and the release rate of testosterone from the matrix model of TTS was studied. It may be concluded that the testosterone solubility in matrices, the rate of water sorption by systems and the pharmaceutical availability of drug can be regulated on a relatively wide scale independently of molecular mass by the amounts of PEGs incorporated into matrices. It was found that in all cases of triphase matrices the liberation process of terosterone was well correlated with Higuchi's equation. The rate of water sorption by PEG and matrices may be described by the equation Q = k square root of t.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 1803388</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Administration, Cutaneous ; Biological and medical sciences ; Cellulose - analogs & derivatives ; General pharmacology ; Medical sciences ; Models, Biological ; Molecular Weight ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyethylene Glycols - pharmacology ; Solubility ; Testosterone - administration & dosage ; Testosterone - chemistry ; Testosterone - pharmacokinetics</subject><ispartof>Pharmazie, 1991-10, Vol.46 (10), p.719-723</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5232349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1803388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CICHON, R</creatorcontrib><creatorcontrib>JANICKI, S</creatorcontrib><title>Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>Polyoxyethylene glycols (PEG) are nontoxic substances, which ones do not irritate the skin, therefore can be used as pharmaceutical excipients to differentiate the properties of various matrices. The effect of variable content and molecular mass of PEG in cellulose acetate matrices on the testosterone solubility, the rate of water sorption and the release rate of testosterone from the matrix model of TTS was studied. It may be concluded that the testosterone solubility in matrices, the rate of water sorption by systems and the pharmaceutical availability of drug can be regulated on a relatively wide scale independently of molecular mass by the amounts of PEGs incorporated into matrices. It was found that in all cases of triphase matrices the liberation process of terosterone was well correlated with Higuchi's equation. The rate of water sorption by PEG and matrices may be described by the equation Q = k square root of t.</description><subject>Administration, Cutaneous</subject><subject>Biological and medical sciences</subject><subject>Cellulose - analogs & derivatives</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Molecular Weight</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Solubility</subject><subject>Testosterone - administration & dosage</subject><subject>Testosterone - chemistry</subject><subject>Testosterone - pharmacokinetics</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFLwzAYxXtQ5pz-CUIOItuhkDRp2h1lzCkMFJznkqVfXCRtapLievYfN9Pi6YP3fjy-986SKcaUpAVh7CK59P4D44xnvJwkE1JiSstymnyvlQIZkFWos2awxwHCYTDQAno3g7TGo_nLerNAtkWdsx24oMGf8HAA1Ijg9BE1tgbzqznR-hpcI8zJd6KDPmiJ_OADNGi-270u0JcOBxTABxtFZ1u4Ss6VMB6uxztL3h7Wu9Vjun3ePK3ut2mX0TyknJFakJzQupAKqNpjVRawlEtcCqkkYxgoABDFM8gZU7kipMihBg6McI7pLLn7y41FPvv4QNVoL8EY0YLtfVXEbXicJYI3I9jvG6irzulGuKEaV4v-7egLL4VRsbXU_h_LM5pRtqQ_BbJ3Lw</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>CICHON, R</creator><creator>JANICKI, S</creator><general>Govi</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone</title><author>CICHON, R ; JANICKI, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-641da1513d7cfe3fb0f87e9c908acfc440e3eee1f62e544f5f1175ede6e416603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Administration, Cutaneous</topic><topic>Biological and medical sciences</topic><topic>Cellulose - analogs & derivatives</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Molecular Weight</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Solubility</topic><topic>Testosterone - administration & dosage</topic><topic>Testosterone - chemistry</topic><topic>Testosterone - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CICHON, R</creatorcontrib><creatorcontrib>JANICKI, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CICHON, R</au><au>JANICKI, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>46</volume><issue>10</issue><spage>719</spage><epage>723</epage><pages>719-723</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>Polyoxyethylene glycols (PEG) are nontoxic substances, which ones do not irritate the skin, therefore can be used as pharmaceutical excipients to differentiate the properties of various matrices. The effect of variable content and molecular mass of PEG in cellulose acetate matrices on the testosterone solubility, the rate of water sorption and the release rate of testosterone from the matrix model of TTS was studied. It may be concluded that the testosterone solubility in matrices, the rate of water sorption by systems and the pharmaceutical availability of drug can be regulated on a relatively wide scale independently of molecular mass by the amounts of PEGs incorporated into matrices. It was found that in all cases of triphase matrices the liberation process of terosterone was well correlated with Higuchi's equation. The rate of water sorption by PEG and matrices may be described by the equation Q = k square root of t.</abstract><cop>Eschborn</cop><pub>Govi</pub><pmid>1803388</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-7144 |
| ispartof | Pharmazie, 1991-10, Vol.46 (10), p.719-723 |
| issn | 0031-7144 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72686338 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Cutaneous Biological and medical sciences Cellulose - analogs & derivatives General pharmacology Medical sciences Models, Biological Molecular Weight Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - pharmacology Solubility Testosterone - administration & dosage Testosterone - chemistry Testosterone - pharmacokinetics |
| title | Effect of polyoxyethylene glycols (PEG) on properties of the matrix model of transdermal therapeutic system (TTS) with testosterone |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T13%3A01%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20polyoxyethylene%20glycols%20(PEG)%20on%20properties%20of%20the%20matrix%20model%20of%20transdermal%20therapeutic%20system%20(TTS)%20with%20testosterone&rft.jtitle=Pharmazie&rft.au=CICHON,%20R&rft.date=1991-10-01&rft.volume=46&rft.issue=10&rft.spage=719&rft.epage=723&rft.pages=719-723&rft.issn=0031-7144&rft.coden=PHARAT&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E72686338%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72686338&rft_id=info:pmid/1803388&rfr_iscdi=true |