Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by β-endorphin in pons/medulla of the μ-opioid receptor knockout mouse

β-Endorphin is a non-selective opioid peptide which binds μ-, δ- and putative ϵ (β-endorphin-sensitive non-μ-, non-δ- and non-κ 1-)-opioid receptors. We have previously reported that β-endorphin-produced G-protein activation is mediated by the stimulation of both μ- and putative ϵ-opioid receptors....

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Veröffentlicht in:	Neuroscience 2002-01, Vol.115 (3), p.715-721
Hauptverfasser:	Mizoguchi, H, Wu, H.-E, Narita, M, Hall, F.S, Sora, I, Uhl, G.R, Nagase, H, Tseng, L.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonist beta-Endorphin - antagonists & inhibitors beta-Endorphin - metabolism Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Buprenorphine - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Enkephalin, Ala-MePhe-Gly- - pharmacology Female Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - drug effects GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) guanosine-5′- O-(3-[ 35S]thio)triphosphate binding Male Medulla Oblongata - drug effects Medulla Oblongata - metabolism Mice Mice, Knockout Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists Narcotics - pharmacology Neurons - drug effects Neurons - metabolism Peptide Fragments - pharmacology Pons - drug effects Pons - metabolism Radioligand Assay Receptors, Opioid - metabolism Receptors, Opioid, mu - deficiency Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - genetics Rhombencephalon - drug effects Rhombencephalon - metabolism Sulfur Radioisotopes Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs
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