The structures of prostaglandin endoperoxide H synthases-1 and -2

Despite the marked differences in their physiological roles, the structures and catalytic functions of the prostaglandin H 2 endoperoxide synthases-1 and -2 (PGHS-1 and -2) are almost completely identical. These integral membrane proteins catalyze the conversion of arachidonic acid to PGG 2 and fina...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2002-08, Vol.68, p.129-152
Hauptverfasser:	Michael Garavito, R, Malkowski, Michael G, DeWitt, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Arachidonic acid Arachidonic Acid - chemistry Arachidonic Acid - metabolism Aspirin Catalytic Domain COX-2 selective inhibitors Cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - metabolism Dimerization Drug binding Fatty acid binding Humans Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Membrane Proteins Models, Molecular Nonsteroidal antiinflammatory drugs Peroxidase Prostaglandin-Endoperoxide Synthases - chemistry Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Protein Binding Protein Conformation Protein Structure, Quaternary Protein Structure, Tertiary X-ray structure
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