Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis
BACKGROUND Aging leads to decline of multiple cutaneous physiological functions including decreased sweating, immune responsiveness, thermoregulation, DNA repair, and sensory and tactile perception. Interestingly, sensory perception, like that for pain or spatial acuity, varies in different body par...
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| Veröffentlicht in: | Archives of dermatology (1960) 2002-11, Vol.138 (11), p.1445-1450 |
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| container_title | Archives of dermatology (1960) |
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| creator | Besné, Isabelle Descombes, Caroline Breton, Lionel |
| description | BACKGROUND Aging leads to decline of multiple cutaneous physiological functions
including decreased sweating, immune responsiveness, thermoregulation, DNA
repair, and sensory and tactile perception. Interestingly, sensory perception,
like that for pain or spatial acuity, varies in different body parts. OBJECTIVE To evaluate epidermal innervation according to age and anatomical site. METHODS Eighty-two biopsy samples from surgical procedures involving 82 patients
of different ages (20-93 years) were analyzed. Four anatomical sites were
examined: 2 from facial areas (upper eyelid and preauricular area) and 2 from
truncal areas (abdomen and mammary area). Epidermal innervation was detected
using a marker of neural cells, the protein gene product 9.5. The basement
membrane was stained with type IV collagen antibodies. The epidermal area
occupied by nerve endings was then calculated using image analysis. RESULTS A trend displaying age-associated decreased epidermal innervation of
facial skin was found. Epidermal innervation of abdominal skin did not change
with age, and an age-associated increased innervation was observed in mammary
skin. Also, the number of epidermal nerves in facial areas tested (palpebral
and preauricular areas) was significantly higher than their number in the
abdomen and mammary area. Eyelid epidermis showed the highest ratio of nerve
fiber surface to epidermal surface. CONCLUSIONS Epidermal nerve density variations could explain the different sensitivity
threshold in different parts of the body. Decreased spatial discrimination
with aging may be associated with decreased epidermal nerve density.Arch Dermatol. 2002;138:1445-1450--> |
| doi_str_mv | 10.1001/archderm.138.11.1445 |
| format | Article |
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including decreased sweating, immune responsiveness, thermoregulation, DNA
repair, and sensory and tactile perception. Interestingly, sensory perception,
like that for pain or spatial acuity, varies in different body parts. OBJECTIVE To evaluate epidermal innervation according to age and anatomical site. METHODS Eighty-two biopsy samples from surgical procedures involving 82 patients
of different ages (20-93 years) were analyzed. Four anatomical sites were
examined: 2 from facial areas (upper eyelid and preauricular area) and 2 from
truncal areas (abdomen and mammary area). Epidermal innervation was detected
using a marker of neural cells, the protein gene product 9.5. The basement
membrane was stained with type IV collagen antibodies. The epidermal area
occupied by nerve endings was then calculated using image analysis. RESULTS A trend displaying age-associated decreased epidermal innervation of
facial skin was found. Epidermal innervation of abdominal skin did not change
with age, and an age-associated increased innervation was observed in mammary
skin. Also, the number of epidermal nerves in facial areas tested (palpebral
and preauricular areas) was significantly higher than their number in the
abdomen and mammary area. Eyelid epidermis showed the highest ratio of nerve
fiber surface to epidermal surface. CONCLUSIONS Epidermal nerve density variations could explain the different sensitivity
threshold in different parts of the body. Decreased spatial discrimination
with aging may be associated with decreased epidermal nerve density.Arch Dermatol. 2002;138:1445-1450--></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archderm.138.11.1445</identifier><identifier>PMID: 12437450</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Culture Techniques ; Epidermis - innervation ; Epidermis - ultrastructure ; Female ; Humans ; Male ; Microscopy, Confocal ; Middle Aged ; Nerve Endings ; Nerve Fibers - ultrastructure ; Probability ; Risk Factors ; Sensation - physiology ; Sensitivity and Specificity ; Skin Aging - pathology ; Statistics, Nonparametric</subject><ispartof>Archives of dermatology (1960), 2002-11, Vol.138 (11), p.1445-1450</ispartof><rights>Copyright American Medical Association Nov 2002</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-76695bbf5c46e76961e276e7d24381421d3179b17750bb2bc59b03db24127f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archderm.138.11.1445$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.138.11.1445$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3327,27901,27902,76232,76235</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12437450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Besné, Isabelle</creatorcontrib><creatorcontrib>Descombes, Caroline</creatorcontrib><creatorcontrib>Breton, Lionel</creatorcontrib><title>Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description>BACKGROUND Aging leads to decline of multiple cutaneous physiological functions
including decreased sweating, immune responsiveness, thermoregulation, DNA
repair, and sensory and tactile perception. Interestingly, sensory perception,
like that for pain or spatial acuity, varies in different body parts. OBJECTIVE To evaluate epidermal innervation according to age and anatomical site. METHODS Eighty-two biopsy samples from surgical procedures involving 82 patients
of different ages (20-93 years) were analyzed. Four anatomical sites were
examined: 2 from facial areas (upper eyelid and preauricular area) and 2 from
truncal areas (abdomen and mammary area). Epidermal innervation was detected
using a marker of neural cells, the protein gene product 9.5. The basement
membrane was stained with type IV collagen antibodies. The epidermal area
occupied by nerve endings was then calculated using image analysis. RESULTS A trend displaying age-associated decreased epidermal innervation of
facial skin was found. Epidermal innervation of abdominal skin did not change
with age, and an age-associated increased innervation was observed in mammary
skin. Also, the number of epidermal nerves in facial areas tested (palpebral
and preauricular areas) was significantly higher than their number in the
abdomen and mammary area. Eyelid epidermis showed the highest ratio of nerve
fiber surface to epidermal surface. CONCLUSIONS Epidermal nerve density variations could explain the different sensitivity
threshold in different parts of the body. Decreased spatial discrimination
with aging may be associated with decreased epidermal nerve density.Arch Dermatol. 2002;138:1445-1450--></description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Culture Techniques</subject><subject>Epidermis - innervation</subject><subject>Epidermis - ultrastructure</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Nerve Endings</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Probability</subject><subject>Risk Factors</subject><subject>Sensation - physiology</subject><subject>Sensitivity and Specificity</subject><subject>Skin Aging - pathology</subject><subject>Statistics, Nonparametric</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1LwzAUhoMoOqc_QBAJXnjXmZOkSXo5dH7AwIuJeBeSNtXKms6kFfbvzdhU8CoHzvOevDwInQOZACFwbUL5XrnQToCpCcAEOM_30AhypjImcrqPRoQQlhVKvh6h4xg_UooqRQ_REVDOJM_JCL3M6tqVPe5qPH1z2PgKT73pu7YpzRIvmt7hzuNb52PTrzfUIo1dWONH7134Mn2T1o3HD0NrPJ6tmk2lJp6gg9osozvdvWO0uJs93zxk86f7x5vpPDOMqz6TQhS5tXVecuGkKAQ4KtNUpX4KOIWKgSwsSJkTa6kt88ISVlnKgcqajdHV9uoqdJ-Di71OX5duuTTedUPUkgrFBaUJvPwHfnRD8KmZpowBJUoWCeJbqAxdjMHVehWa1oS1BqI3yvWPcp2UawC9UZ5iF7vbg21d9RfaOU7A2RYwrfndclkQIdg3206FGw</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Besné, Isabelle</creator><creator>Descombes, Caroline</creator><creator>Breton, Lionel</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis</title><author>Besné, Isabelle ; Descombes, Caroline ; Breton, Lionel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-76695bbf5c46e76961e276e7d24381421d3179b17750bb2bc59b03db24127f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Culture Techniques</topic><topic>Epidermis - innervation</topic><topic>Epidermis - ultrastructure</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Nerve Endings</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Probability</topic><topic>Risk Factors</topic><topic>Sensation - physiology</topic><topic>Sensitivity and Specificity</topic><topic>Skin Aging - pathology</topic><topic>Statistics, Nonparametric</topic><toplevel>online_resources</toplevel><creatorcontrib>Besné, Isabelle</creatorcontrib><creatorcontrib>Descombes, Caroline</creatorcontrib><creatorcontrib>Breton, Lionel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Besné, Isabelle</au><au>Descombes, Caroline</au><au>Breton, Lionel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>138</volume><issue>11</issue><spage>1445</spage><epage>1450</epage><pages>1445-1450</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><abstract>BACKGROUND Aging leads to decline of multiple cutaneous physiological functions
including decreased sweating, immune responsiveness, thermoregulation, DNA
repair, and sensory and tactile perception. Interestingly, sensory perception,
like that for pain or spatial acuity, varies in different body parts. OBJECTIVE To evaluate epidermal innervation according to age and anatomical site. METHODS Eighty-two biopsy samples from surgical procedures involving 82 patients
of different ages (20-93 years) were analyzed. Four anatomical sites were
examined: 2 from facial areas (upper eyelid and preauricular area) and 2 from
truncal areas (abdomen and mammary area). Epidermal innervation was detected
using a marker of neural cells, the protein gene product 9.5. The basement
membrane was stained with type IV collagen antibodies. The epidermal area
occupied by nerve endings was then calculated using image analysis. RESULTS A trend displaying age-associated decreased epidermal innervation of
facial skin was found. Epidermal innervation of abdominal skin did not change
with age, and an age-associated increased innervation was observed in mammary
skin. Also, the number of epidermal nerves in facial areas tested (palpebral
and preauricular areas) was significantly higher than their number in the
abdomen and mammary area. Eyelid epidermis showed the highest ratio of nerve
fiber surface to epidermal surface. CONCLUSIONS Epidermal nerve density variations could explain the different sensitivity
threshold in different parts of the body. Decreased spatial discrimination
with aging may be associated with decreased epidermal nerve density.Arch Dermatol. 2002;138:1445-1450--></abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>12437450</pmid><doi>10.1001/archderm.138.11.1445</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-987X |
| ispartof | Archives of dermatology (1960), 2002-11, Vol.138 (11), p.1445-1450 |
| issn | 0003-987X 2168-6068 1538-3652 2168-6084 |
| language | eng |
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| source | MEDLINE; American Medical Association Journals |
| subjects | Adult Age Factors Aged Aged, 80 and over Culture Techniques Epidermis - innervation Epidermis - ultrastructure Female Humans Male Microscopy, Confocal Middle Aged Nerve Endings Nerve Fibers - ultrastructure Probability Risk Factors Sensation - physiology Sensitivity and Specificity Skin Aging - pathology Statistics, Nonparametric |
| title | Effect of Age and Anatomical Site on Density of Sensory Innervation in Human Epidermis |
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