The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation of Catecholamine Secretion
: Chromaffin cells express components of the plasminogen/plasmin system, including its major activator, tissue plasminogen activator (t‐PA), and high‐affinity cellular receptors for plasminogen, which promote local concentration and activation of plasminogen at the cell surface. Our studies suggest...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2002-10, Vol.971 (1), p.445-449 |
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| container_issue | 1 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | JIANG, QIJIAO YASOTHORNSRIKUL, SUKKID TAUPENOT, LAURENT MILES, LINDSEY A. PARMER, ROBERT J. |
| description | : Chromaffin cells express components of the plasminogen/plasmin system, including its major activator, tissue plasminogen activator (t‐PA), and high‐affinity cellular receptors for plasminogen, which promote local concentration and activation of plasminogen at the cell surface. Our studies suggest that plasmin participates in local neuroendocrine prohormone processing and that perturbation of this system profoundly affects the secretory characteristics of the cells. These results suggest the presence of a local, functionally active, chromaffin cell plasminogen/plasmin system that plays a major role in the regulation of catecholamine release from catecholaminergic cells. |
| doi_str_mv | 10.1111/j.1749-6632.2002.tb04506.x |
| format | Article |
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Our studies suggest that plasmin participates in local neuroendocrine prohormone processing and that perturbation of this system profoundly affects the secretory characteristics of the cells. These results suggest the presence of a local, functionally active, chromaffin cell plasminogen/plasmin system that plays a major role in the regulation of catecholamine release from catecholaminergic cells.</description><subject>Animals</subject><subject>catecholamines</subject><subject>Catecholamines - metabolism</subject><subject>Cattle</subject><subject>Chromogranin A</subject><subject>Chromogranins - metabolism</subject><subject>DNA, Complementary - metabolism</subject><subject>Fibrinolysin - metabolism</subject><subject>Humans</subject><subject>PC12 Cells</subject><subject>Pheochromocytoma - metabolism</subject><subject>plasmin</subject><subject>Plasminogen - metabolism</subject><subject>processing</subject><subject>proteolysis</subject><subject>Rats</subject><subject>receptor</subject><subject>Tissue Plasminogen Activator - metabolism</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNFu0zAUhi0EYt3gFZDFBXfJ7GPHTrhBI4IyreomWkBwYznuyZqSxCNOtfbtSdRoXOMbWzr__x35I-QtZzEfzuUu5lpmkVICYmAM4r5gMmEqPjwjs6fRczJjTOsozUCckfMQdoxxSKV-Sc44SJFyBTNSrLdIF97Zmubbzje2LKuW5ljX9K62oalaf4_t5fSmq2PosaG23dB-KH7F-31t-8q31Jc0tz26ra_tkES6QtfhOHpFXpS2Dvh6ui_It8-f1vmXaHE7v86vFpGTLEuiInUCMs3tpkTlEJgUdpNKAaCFA12UpUq5zSATwCBzmutEcUAJZeFEgqm4IO9O3IfO_9lj6E1TBTf8xLbo98FoUCnTwIfg-1PQdT6EDkvz0FWN7Y6GMzMaNjszajSjRjMaNpNhcxjKb6Yt-6LBzb_qpHQIfDgFHqsaj_-BNsufVyspk4EQnQjVIPvwRLDdb6O00In5sZybZPnx12K-vjHfxV8Wmprl</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>JIANG, QIJIAO</creator><creator>YASOTHORNSRIKUL, SUKKID</creator><creator>TAUPENOT, LAURENT</creator><creator>MILES, LINDSEY A.</creator><creator>PARMER, ROBERT J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation of Catecholamine Secretion</title><author>JIANG, QIJIAO ; YASOTHORNSRIKUL, SUKKID ; TAUPENOT, LAURENT ; MILES, LINDSEY A. ; PARMER, ROBERT J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4095-b8c32971adfe6ce2043ad8432273c27bff681a92932029c7175612e42fbc35e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>catecholamines</topic><topic>Catecholamines - metabolism</topic><topic>Cattle</topic><topic>Chromogranin A</topic><topic>Chromogranins - metabolism</topic><topic>DNA, Complementary - metabolism</topic><topic>Fibrinolysin - metabolism</topic><topic>Humans</topic><topic>PC12 Cells</topic><topic>Pheochromocytoma - metabolism</topic><topic>plasmin</topic><topic>Plasminogen - metabolism</topic><topic>processing</topic><topic>proteolysis</topic><topic>Rats</topic><topic>receptor</topic><topic>Tissue Plasminogen Activator - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JIANG, QIJIAO</creatorcontrib><creatorcontrib>YASOTHORNSRIKUL, SUKKID</creatorcontrib><creatorcontrib>TAUPENOT, LAURENT</creatorcontrib><creatorcontrib>MILES, LINDSEY A.</creatorcontrib><creatorcontrib>PARMER, ROBERT J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JIANG, QIJIAO</au><au>YASOTHORNSRIKUL, SUKKID</au><au>TAUPENOT, LAURENT</au><au>MILES, LINDSEY A.</au><au>PARMER, ROBERT J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation of Catecholamine Secretion</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2002-10</date><risdate>2002</risdate><volume>971</volume><issue>1</issue><spage>445</spage><epage>449</epage><pages>445-449</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Chromaffin cells express components of the plasminogen/plasmin system, including its major activator, tissue plasminogen activator (t‐PA), and high‐affinity cellular receptors for plasminogen, which promote local concentration and activation of plasminogen at the cell surface. 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| ispartof | Annals of the New York Academy of Sciences, 2002-10, Vol.971 (1), p.445-449 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals catecholamines Catecholamines - metabolism Cattle Chromogranin A Chromogranins - metabolism DNA, Complementary - metabolism Fibrinolysin - metabolism Humans PC12 Cells Pheochromocytoma - metabolism plasmin Plasminogen - metabolism processing proteolysis Rats receptor Tissue Plasminogen Activator - metabolism |
| title | The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation of Catecholamine Secretion |
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