Pharmacokinetics of darbepoetin alfa in pediatric patients with chronic kidney disease

Darbepoetin alfa is a novel erythropoiesis-stimulating protein with a two- to threefold longer half-life than recombinant human erythropoietin (epoetin) in adult patients with chronic kidney disease (CKD). This randomized, open-label, crossover study was conducted to determine the pharmacokinetic pr...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2002-11, Vol.17 (11), p.933-937
Hauptverfasser:	Lerner, Gary, Kale, Arundhati S, Warady, Bradley A, Jabs, Kathy, Bunchman, Timothy E, Heatherington, Anne, Olson, Kurt, Messer-Mann, Louise, Maroni, Bradley J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Area Under Curve Biological Availability Child Child, Preschool Cross-Over Studies Darbepoetin alfa Enzyme-Linked Immunosorbent Assay Erythropoietin - analogs & derivatives Erythropoietin - pharmacokinetics Female Half-Life Humans Infant Injections, Intravenous Injections, Subcutaneous Kidney Failure, Chronic - metabolism Male Renal Dialysis
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