Plasmodium chabaudi: rosetting in a rodent malaria model
Rosetting is a property of many malaria parasite species that has been linked to virulence in the major species infecting humans, Plasmodium falciparum. Here, the basic properties of rosettes in the rodent malaria laboratory model, P. chabaudi, were studied with a view to future studies on the role...
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| Veröffentlicht in: | Experimental parasitology 2002-06, Vol.101 (2), p.121-128 |
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| creator | Mackinnon, Margaret J Walker, Polly R Rowe, J.Alexandra |
| description | Rosetting is a property of many malaria parasite species that has been linked to virulence in the major species infecting humans,
Plasmodium falciparum. Here, the basic properties of rosettes in the rodent malaria laboratory model,
P. chabaudi, were studied with a view to future studies on the role of rosetting in malaria parasite virulence and transmission. Rosetting occurred in 14 out of the 15
P. chabaudi clones studied, varied consistently between clones, and ranged between 9 and 37% at full parasite maturity. Rosetting frequency markedly declined after the mouse reached peak parasitemia, possibly due to host immunity. Consistent with
P. falciparum and
P. vivax, rosettes in
P. chabaudi were disrupted by treatment with trypsin and EDTA. However,
P. chabaudi rosettes were insensitive to sulfated glycoconjugates (heparin, heparan sulfate and fucoidan). The molecular basis of rosetting in
P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species.
Index Descriptors and Abbreviations: Plasmodium chabaudi chabaudi,
P. c. adami; rodent malaria; rosette; CI, confidence interval; EDTA, ethylene-diamine-tetraacetic acid; SEM, standard error of mean; BSA, bovine serum albumin. |
| doi_str_mv | 10.1016/S0014-4894(02)00103-0 |
| format | Article |
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Plasmodium falciparum. Here, the basic properties of rosettes in the rodent malaria laboratory model,
P. chabaudi, were studied with a view to future studies on the role of rosetting in malaria parasite virulence and transmission. Rosetting occurred in 14 out of the 15
P. chabaudi clones studied, varied consistently between clones, and ranged between 9 and 37% at full parasite maturity. Rosetting frequency markedly declined after the mouse reached peak parasitemia, possibly due to host immunity. Consistent with
P. falciparum and
P. vivax, rosettes in
P. chabaudi were disrupted by treatment with trypsin and EDTA. However,
P. chabaudi rosettes were insensitive to sulfated glycoconjugates (heparin, heparan sulfate and fucoidan). The molecular basis of rosetting in
P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species.
Index Descriptors and Abbreviations: Plasmodium chabaudi chabaudi,
P. c. adami; rodent malaria; rosette; CI, confidence interval; EDTA, ethylene-diamine-tetraacetic acid; SEM, standard error of mean; BSA, bovine serum albumin.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/S0014-4894(02)00103-0</identifier><identifier>PMID: 12427466</identifier><identifier>CODEN: EXPAAA</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Anticoagulants - pharmacology ; Biological and medical sciences ; Disease Models, Animal ; Edetic Acid - pharmacology ; Erythrocytes - cytology ; Erythrocytes - parasitology ; Fundamental and applied biological sciences. Psychology ; Glycoconjugates - pharmacology ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria - immunology ; Malaria - parasitology ; Male ; Mice ; Mice, Inbred C57BL ; Parasitemia - immunology ; Parasitemia - parasitology ; Plasmodium chabaudi - drug effects ; Plasmodium chabaudi - immunology ; Plasmodium chabaudi - pathogenicity ; Protozoa ; Rosette Formation ; Serial Passage ; Trypsin - pharmacology ; Virulence</subject><ispartof>Experimental parasitology, 2002-06, Vol.101 (2), p.121-128</ispartof><rights>2002</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8448a21f0d3c8e6ea26f0be335678e9dc9b911805f6e8a8acc16e5acacbd68f63</citedby><cites>FETCH-LOGICAL-c422t-8448a21f0d3c8e6ea26f0be335678e9dc9b911805f6e8a8acc16e5acacbd68f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-4894(02)00103-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14368471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12427466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackinnon, Margaret J</creatorcontrib><creatorcontrib>Walker, Polly R</creatorcontrib><creatorcontrib>Rowe, J.Alexandra</creatorcontrib><title>Plasmodium chabaudi: rosetting in a rodent malaria model</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>Rosetting is a property of many malaria parasite species that has been linked to virulence in the major species infecting humans,
Plasmodium falciparum. Here, the basic properties of rosettes in the rodent malaria laboratory model,
P. chabaudi, were studied with a view to future studies on the role of rosetting in malaria parasite virulence and transmission. Rosetting occurred in 14 out of the 15
P. chabaudi clones studied, varied consistently between clones, and ranged between 9 and 37% at full parasite maturity. Rosetting frequency markedly declined after the mouse reached peak parasitemia, possibly due to host immunity. Consistent with
P. falciparum and
P. vivax, rosettes in
P. chabaudi were disrupted by treatment with trypsin and EDTA. However,
P. chabaudi rosettes were insensitive to sulfated glycoconjugates (heparin, heparan sulfate and fucoidan). The molecular basis of rosetting in
P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species.
Index Descriptors and Abbreviations: Plasmodium chabaudi chabaudi,
P. c. adami; rodent malaria; rosette; CI, confidence interval; EDTA, ethylene-diamine-tetraacetic acid; SEM, standard error of mean; BSA, bovine serum albumin.</description><subject>Animals</subject><subject>Anticoagulants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Edetic Acid - pharmacology</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoconjugates - pharmacology</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Malaria - immunology</subject><subject>Malaria - parasitology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Parasitemia - immunology</subject><subject>Parasitemia - parasitology</subject><subject>Plasmodium chabaudi - drug effects</subject><subject>Plasmodium chabaudi - immunology</subject><subject>Plasmodium chabaudi - pathogenicity</subject><subject>Protozoa</subject><subject>Rosette Formation</subject><subject>Serial Passage</subject><subject>Trypsin - pharmacology</subject><subject>Virulence</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtL5TAQgIOs6PHyE1z6sqIP1Umapum-LCLeQFBQn8M0mbqRXjRpBf-90XPQR19mGPjm9jG2x-GIA1fHdwBc5lLX8gDEYSqgyGGNLTjUkAsp619s8YVssq0YnwBAcyE32GaKopJKLZi-7TD2o_Nzn9n_2ODs_N8sjJGmyQ-PmR8yTKWjYcp67DB4zBJO3Q5bb7GLtLvK2-zh_Oz-9DK_vrm4Oj25zq0UYsq1lBoFb8EVVpMiFKqFhoqiVJWm2tm6qTnXULaKNGq0lisq0aJtnNKtKrbZ_nLucxhfZoqT6X201HU40DhHUwlVlaqofgS5VrKstEhguQRtejMGas1z8D2GN8PBfLg1n27NhzgDwny6NZD6fq8WzE1P7rtrJTMBf1YARotdG3CwPn5zslBaVjxx_5YcJW-vnoKJ1tNgyflAdjJu9D-c8g50spTW</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Mackinnon, Margaret J</creator><creator>Walker, Polly R</creator><creator>Rowe, J.Alexandra</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Plasmodium chabaudi: rosetting in a rodent malaria model</title><author>Mackinnon, Margaret J ; Walker, Polly R ; Rowe, J.Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8448a21f0d3c8e6ea26f0be335678e9dc9b911805f6e8a8acc16e5acacbd68f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anticoagulants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Edetic Acid - pharmacology</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - parasitology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoconjugates - pharmacology</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Malaria - immunology</topic><topic>Malaria - parasitology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Parasitemia - immunology</topic><topic>Parasitemia - parasitology</topic><topic>Plasmodium chabaudi - drug effects</topic><topic>Plasmodium chabaudi - immunology</topic><topic>Plasmodium chabaudi - pathogenicity</topic><topic>Protozoa</topic><topic>Rosette Formation</topic><topic>Serial Passage</topic><topic>Trypsin - pharmacology</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackinnon, Margaret J</creatorcontrib><creatorcontrib>Walker, Polly R</creatorcontrib><creatorcontrib>Rowe, J.Alexandra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackinnon, Margaret J</au><au>Walker, Polly R</au><au>Rowe, J.Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasmodium chabaudi: rosetting in a rodent malaria model</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>101</volume><issue>2</issue><spage>121</spage><epage>128</epage><pages>121-128</pages><issn>0014-4894</issn><eissn>1090-2449</eissn><coden>EXPAAA</coden><abstract>Rosetting is a property of many malaria parasite species that has been linked to virulence in the major species infecting humans,
Plasmodium falciparum. Here, the basic properties of rosettes in the rodent malaria laboratory model,
P. chabaudi, were studied with a view to future studies on the role of rosetting in malaria parasite virulence and transmission. Rosetting occurred in 14 out of the 15
P. chabaudi clones studied, varied consistently between clones, and ranged between 9 and 37% at full parasite maturity. Rosetting frequency markedly declined after the mouse reached peak parasitemia, possibly due to host immunity. Consistent with
P. falciparum and
P. vivax, rosettes in
P. chabaudi were disrupted by treatment with trypsin and EDTA. However,
P. chabaudi rosettes were insensitive to sulfated glycoconjugates (heparin, heparan sulfate and fucoidan). The molecular basis of rosetting in
P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species.
Index Descriptors and Abbreviations: Plasmodium chabaudi chabaudi,
P. c. adami; rodent malaria; rosette; CI, confidence interval; EDTA, ethylene-diamine-tetraacetic acid; SEM, standard error of mean; BSA, bovine serum albumin.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>12427466</pmid><doi>10.1016/S0014-4894(02)00103-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Anticoagulants - pharmacology Biological and medical sciences Disease Models, Animal Edetic Acid - pharmacology Erythrocytes - cytology Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Glycoconjugates - pharmacology Life cycle. Host-agent relationship. Pathogenesis Malaria - immunology Malaria - parasitology Male Mice Mice, Inbred C57BL Parasitemia - immunology Parasitemia - parasitology Plasmodium chabaudi - drug effects Plasmodium chabaudi - immunology Plasmodium chabaudi - pathogenicity Protozoa Rosette Formation Serial Passage Trypsin - pharmacology Virulence |
| title | Plasmodium chabaudi: rosetting in a rodent malaria model |
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