Extravasation of staphylococcal α-toxin in normal and injured CNS regions lacking blood-brain barrier function: observations after ventral root replantation

Staphylococcus aureus plays an important role as a bacterial pathogen after traumatic injury. The majority of isolated strains produces α-toxin, a 33-kDa protein, with membrane-damaging and lethal effects. The central nervous system (CNS) has been considered as the possible target for the lethal act...

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Veröffentlicht in:	Brain research 1991-09, Vol.559 (2), p.276-282
Hauptverfasser:	Sjo¨gren, AnnMargret, Thelestam, Monica, Blomqvist, Lennart, Linda˚, Hans, Remahl, Sten, Risling, Ma˚rten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Bacterial toxin Bacterial Toxins - metabolism Blood-brain barrier Blood-Brain Barrier - physiology Central nervous system regeneration Female Hemolysin Proteins - metabolism Immunohistochemistry Infection Mice Mice, Inbred BALB C Nerve Regeneration - physiology Rats Rats, Inbred Strains Replantation Spinal Cord - metabolism Spinal Cord - ultrastructure Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal cord lesion Spinal Nerve Roots - surgery
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