Immunogenicity of hepatitis B surface antigen derived from the baculovirus expression vector system: a mouse potency study
A standard mouse potency test was performed to evaluate the immunogenicity of recombinant hepatitis B surface antigen (HBsAg) produced in the baculovirus/insect cell expression system. Groups of NIH Swiss mice were immunized with serial four-fold amounts of either baculovirus-derived HBsAg adsorbed...
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| Veröffentlicht in: | Biologicals 1991-10, Vol.19 (4), p.347-353 |
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| creator | Attanasio, Roberta Lanford, Robert E. Dilley, Dennis Stunz, Gregory W. Notvall, Lena Henderson, A. Burl Kennedy, Ronald C. |
| description | A standard mouse potency test was performed to evaluate the immunogenicity of recombinant hepatitis B surface antigen (HBsAg) produced in the baculovirus/insect cell expression system. Groups of NIH Swiss mice were immunized with serial four-fold amounts of either baculovirus-derived HBsAg adsorbed to aluminum sulfate or a commercially available yeast-derived recombinant HBsAg vaccine preparation. Results from these experiments showed that the effective dose of baculovirus-and yeast-derived HBsAg vaccine preparations necessary to seroconvert 50% of the animals were similar. The duration of the antibody response to HBsAg was studied in mice immunized with the highest doses of the two recombinant vaccine preparations 3 and 6 months after injection. No decrease in the anti-HBs response was observed 6 months after injection. No decrease in the anti-HBs response was observed 6 months after immunization with either of the two vaccine preparations. These results indicate that the baculovirus-derived recombinant HBsAg could serve as an alternative vaccine candidate for hepatitis B virus. |
| doi_str_mv | 10.1016/S1045-1056(05)80024-7 |
| format | Article |
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No decrease in the anti-HBs response was observed 6 months after injection. No decrease in the anti-HBs response was observed 6 months after immunization with either of the two vaccine preparations. These results indicate that the baculovirus-derived recombinant HBsAg could serve as an alternative vaccine candidate for hepatitis B virus.</description><identifier>ISSN: 1045-1056</identifier><identifier>EISSN: 1095-8320</identifier><identifier>DOI: 10.1016/S1045-1056(05)80024-7</identifier><identifier>PMID: 1797045</identifier><language>eng</language><publisher>Kent: Elsevier Ltd</publisher><subject>Animals ; Baculoviridae - genetics ; baculovirus ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Vectors ; Hepatitis B Antibodies - biosynthesis ; Hepatitis B Surface Antigens - analysis ; Hepatitis B Surface Antigens - genetics ; Hepatitis B Surface Antigens - immunology ; hepatitis B virus ; Immunization ; Mice ; Microbiology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - analysis ; Vaccines, Synthetic - immunology ; Viral Hepatitis Vaccines - analysis ; Viral Hepatitis Vaccines - immunology ; Virology</subject><ispartof>Biologicals, 1991-10, Vol.19 (4), p.347-353</ispartof><rights>1991 The International Association of Biological Standardization</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-3d339afef8506a20479f6249f9f1f84bb8b3bb0c98778324000251fc7e39f43</citedby><cites>FETCH-LOGICAL-c467t-3d339afef8506a20479f6249f9f1f84bb8b3bb0c98778324000251fc7e39f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1045-1056(05)80024-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5114330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1797045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attanasio, Roberta</creatorcontrib><creatorcontrib>Lanford, Robert E.</creatorcontrib><creatorcontrib>Dilley, Dennis</creatorcontrib><creatorcontrib>Stunz, Gregory W.</creatorcontrib><creatorcontrib>Notvall, Lena</creatorcontrib><creatorcontrib>Henderson, A. Burl</creatorcontrib><creatorcontrib>Kennedy, Ronald C.</creatorcontrib><title>Immunogenicity of hepatitis B surface antigen derived from the baculovirus expression vector system: a mouse potency study</title><title>Biologicals</title><addtitle>Biologicals</addtitle><description>A standard mouse potency test was performed to evaluate the immunogenicity of recombinant hepatitis B surface antigen (HBsAg) produced in the baculovirus/insect cell expression system. Groups of NIH Swiss mice were immunized with serial four-fold amounts of either baculovirus-derived HBsAg adsorbed to aluminum sulfate or a commercially available yeast-derived recombinant HBsAg vaccine preparation. Results from these experiments showed that the effective dose of baculovirus-and yeast-derived HBsAg vaccine preparations necessary to seroconvert 50% of the animals were similar. The duration of the antibody response to HBsAg was studied in mice immunized with the highest doses of the two recombinant vaccine preparations 3 and 6 months after injection. No decrease in the anti-HBs response was observed 6 months after injection. No decrease in the anti-HBs response was observed 6 months after immunization with either of the two vaccine preparations. These results indicate that the baculovirus-derived recombinant HBsAg could serve as an alternative vaccine candidate for hepatitis B virus.</description><subject>Animals</subject><subject>Baculoviridae - genetics</subject><subject>baculovirus</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Vectors</subject><subject>Hepatitis B Antibodies - biosynthesis</subject><subject>Hepatitis B Surface Antigens - analysis</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>hepatitis B virus</subject><subject>Immunization</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Synthetic - analysis</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Viral Hepatitis Vaccines - analysis</subject><subject>Viral Hepatitis Vaccines - immunology</subject><subject>Virology</subject><issn>1045-1056</issn><issn>1095-8320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhSMEKm3hESp5gRBdBOzYjmM2FVT8VKrEouwtxxlToyS-eJwrwtPj9F7BsitbOp99Zs6pqgtG3zLK2nd3jApZMyrbN1RedpQ2olZPqlNGtaw73tCn2_2IPK_OEH9SyphQ4qQ6YUqrop1Wf26maZnjD5iDC3kl0ZN72NkcckDykeCSvHVA7JxDYcgAKexhID7FieR7IL11yxj3IS1I4PcuAWKIM9mDyzERXDHD9J5YMsUFgexihtmtBPMyrC-qZ96OCC-P53l19_nT9-uv9e23LzfXH25rJ1qVaz5wrq0H30na2oYKpX3bCO21Z74Tfd_1vO-p051SZW1BSxKSeaeAay_4efX68OsuxV8LYDZTQAfjaGcoMxnVtIpLrh4FWSu00A0toDyALkXEBN7sUphsWg2jZqvGPFRjttwNleahGrMZXBwNln6C4f-rQxdFf3XULTo7-mRnF_AfJkt3nG_2VwcMSmb7AMmgCyVVGEIqqZshhkcG-QsdT6xM</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Attanasio, Roberta</creator><creator>Lanford, Robert E.</creator><creator>Dilley, Dennis</creator><creator>Stunz, Gregory W.</creator><creator>Notvall, Lena</creator><creator>Henderson, A. 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Burl</au><au>Kennedy, Ronald C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunogenicity of hepatitis B surface antigen derived from the baculovirus expression vector system: a mouse potency study</atitle><jtitle>Biologicals</jtitle><addtitle>Biologicals</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>19</volume><issue>4</issue><spage>347</spage><epage>353</epage><pages>347-353</pages><issn>1045-1056</issn><eissn>1095-8320</eissn><abstract>A standard mouse potency test was performed to evaluate the immunogenicity of recombinant hepatitis B surface antigen (HBsAg) produced in the baculovirus/insect cell expression system. Groups of NIH Swiss mice were immunized with serial four-fold amounts of either baculovirus-derived HBsAg adsorbed to aluminum sulfate or a commercially available yeast-derived recombinant HBsAg vaccine preparation. 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| ispartof | Biologicals, 1991-10, Vol.19 (4), p.347-353 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Baculoviridae - genetics baculovirus Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Genetic Vectors Hepatitis B Antibodies - biosynthesis Hepatitis B Surface Antigens - analysis Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology hepatitis B virus Immunization Mice Microbiology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - analysis Vaccines, Synthetic - immunology Viral Hepatitis Vaccines - analysis Viral Hepatitis Vaccines - immunology Virology |
| title | Immunogenicity of hepatitis B surface antigen derived from the baculovirus expression vector system: a mouse potency study |
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