Acute inhibition of glutathione biosynthesis alters endothelial function and blood pressure in rats

The cardiovascular and biochemical responses during acute oxidative stress induced by d, l-buthionine-( S, R)-sulfoximine (BSO) were investigated in Sprague–Dawley rats. Mean arterial pressure, heart rate and vascular reactivity were measured after subcutaneous injection of BSO (4 mmol/kg). Control...

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Veröffentlicht in:	European journal of pharmacology 2002-11, Vol.454 (2), p.217-223
Hauptverfasser:	Ganafa, Agaba A, Socci, Robin R, Eatman, Danita, Silvestrova, Natalia, Abukhalaf, Imad K, Bayorh, Mohamed A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Buthionine Sulfoximine - pharmacology Dose-Response Relationship, Drug Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Glutathione Glutathione - antagonists & inhibitors Glutathione - biosynthesis Male Nitric Oxide - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Sprague-Dawley Space life sciences
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