Caffeine-induced Ca2+ release inhibits GABAA responsiveness in rat identified native primary afferents

Caffeine-induced Ca2+ release inhibits GABAA responsiveness in rat identified native primary afferents

It has been shown previously that an increase in cytoplasmic Ca2+ concentration depresses the GABA-A response. However, little attention has been paid to the Ca2+ source involved. In the present study, we show that the Ca2+ increase triggered by caffeine-induced Ca2+ release from the intracellular p...

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Veröffentlicht in:European journal of pharmacology 1991-10, Vol.203 (1), p.137-140
Hauptverfasser: DESAULLES, E, BOUX, O, FELTZ, P
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - drug effects
Animals
Biological and medical sciences
Caffeine - pharmacology
Calcium - metabolism
Electric Stimulation
gamma-Aminobutyric Acid - physiology
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
In Vitro Techniques
Medical sciences
Neurons, Afferent - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Ryanodine - pharmacology
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Zusammenfassung:It has been shown previously that an increase in cytoplasmic Ca2+ concentration depresses the GABA-A response. However, little attention has been paid to the Ca2+ source involved. In the present study, we show that the Ca2+ increase triggered by caffeine-induced Ca2+ release from the intracellular pool inhibits the GABA-A response, whereas Ca2+ influx through voltage-activated Ca2+ channels has no effect on this response.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(91)90803-X