Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications
Complement-fixing adrenal medullary antibodies were examined in sera from 170 (114 Type 1 and 56 Type 2) diabetic patients and normal subjects by indirect immunofluorescence methods. Two types of antibodies were detected; one showed a homogeneous immunofluorescence pattern (homogeneous-type) and the...
Gespeichert in:
| Veröffentlicht in: | Journal of autoimmunity 1991-10, Vol.4 (5), p.807-818 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 818 |
|---|---|
| container_issue | 5 |
| container_start_page | 807 |
| container_title | Journal of autoimmunity |
| container_volume | 4 |
| creator | Itoh, Naoto Hanafusa, Toshiaki Katsura, Hayato Yamamoto, Koji Takeda, Akira Kurahashi, Akio Nabika, Tadashi Miyazaki, Atsushi Miyagawa, Jun-ichiro Kono, Norio Tarui, Seiichiro |
| description | Complement-fixing adrenal medullary antibodies were examined in sera from 170 (114 Type 1 and 56 Type 2) diabetic patients and normal subjects by indirect immunofluorescence methods. Two types of antibodies were detected; one showed a homogeneous immunofluorescence pattern (homogeneous-type) and the other a spotty pattern (spotty-type) in the cytoplasm of adrenal medullary cells. Both antibodies were IgG class and adrenal medulla-specific. The prevalence of the homogeneous-type was significantly higher in Type 1 diabetic patients with disease duration under 1 year (36%) than in those with duration of 1 year or more (1.1%), in Type 2 diabetic patients (1.8%) or in normal subjects (0%;
P |
| doi_str_mv | 10.1016/0896-8411(91)90175-C |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72672939</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>089684119190175C</els_id><sourcerecordid>16084132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-c6d4c2f5a28be2775670cd62beac5973143a437157031efd77f1a668c54086863</originalsourceid><addsrcrecordid>eNqFkV-LFiEUxiWK7d2tb1DgVexCUzqOOu5FEC_bH1ioi7drcfQMGL46qbOxn6KvnMO71F2BIJzzPOfo70HoBSVvKKHiLRmV6MaB0ktFrxShknf7R2hHieKdolw-Rrs_kqfovJTvhFDKOT9DZ1QqSfpxh34dfiZc7xcoOM3YrDWZWP2UnG-VmrBxGaIJ-AhuDcHke2whhIJ9xIfmwhRf-ljW4GPnYIHoINYr7LyZoHqLF1N9q5Rr_DXDnQkQLbzGS04L5LqtMNFhf1yCt02ZYnmGnswmFHj-cF-gbx9uDvtP3e2Xj5_37287ywirnRVusP3MTT9O0EvJhSTWiX4CY7mSjA7MDEw2CoRRmJ2UMzVCjJYPZBSjYBfo1Wlue8uPFUrVR1-2r5kIaS1a9kL2iqn_CqkgDTDrm3A4CW1OpWSY9ZL9sRHTlOgtML2lobc0tGpnC0zvm-3lw_x1apD_mk4Jtf67Ux8ajTsPWRfrN4zOZ7BVu-T_veA3Qmimkw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16084132</pqid></control><display><type>article</type><title>Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Itoh, Naoto ; Hanafusa, Toshiaki ; Katsura, Hayato ; Yamamoto, Koji ; Takeda, Akira ; Kurahashi, Akio ; Nabika, Tadashi ; Miyazaki, Atsushi ; Miyagawa, Jun-ichiro ; Kono, Norio ; Tarui, Seiichiro</creator><creatorcontrib>Itoh, Naoto ; Hanafusa, Toshiaki ; Katsura, Hayato ; Yamamoto, Koji ; Takeda, Akira ; Kurahashi, Akio ; Nabika, Tadashi ; Miyazaki, Atsushi ; Miyagawa, Jun-ichiro ; Kono, Norio ; Tarui, Seiichiro</creatorcontrib><description>Complement-fixing adrenal medullary antibodies were examined in sera from 170 (114 Type 1 and 56 Type 2) diabetic patients and normal subjects by indirect immunofluorescence methods. Two types of antibodies were detected; one showed a homogeneous immunofluorescence pattern (homogeneous-type) and the other a spotty pattern (spotty-type) in the cytoplasm of adrenal medullary cells. Both antibodies were IgG class and adrenal medulla-specific. The prevalence of the homogeneous-type was significantly higher in Type 1 diabetic patients with disease duration under 1 year (36%) than in those with duration of 1 year or more (1.1%), in Type 2 diabetic patients (1.8%) or in normal subjects (0%;
P <0.01). Conversely, the prevalence of the spotty-type was not significantly different among all subjects examined (3.6–4.5%). The epitope for the homogeneous-type is likely to be a glycoconjugate since binding of this antibody was abolished after periodate oxidation. The epitope for spotty-type antibody is considered to be a peptide since it was trypsin sensitive. Patients who were positive for the homogeneous-type were also positive for islet cell antibodies, although their antibody titers were not correlated. We conclude that (1) adrenal medullary antibodies are of homogeneous-type or spotty-type and the antigenic determinants of these antibodies are different, and (2) the prevalence of the homogeneous-type is significantly higher in newly diagnosed Type 1 diabetic patients and its presence is associated with that of islet cell antibodies.</description><identifier>ISSN: 0896-8411</identifier><identifier>EISSN: 1095-9157</identifier><identifier>DOI: 10.1016/0896-8411(91)90175-C</identifier><identifier>PMID: 1797028</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adrenal Medulla - immunology ; Adult ; Aged ; Antibody Specificity ; Autoantibodies - analysis ; Autoantibodies - immunology ; Child, Preschool ; Complement System Proteins - immunology ; Diabetes Mellitus, Type 1 - immunology ; Diabetic Neuropathies - immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G - analysis ; Infant ; Male ; Middle Aged</subject><ispartof>Journal of autoimmunity, 1991-10, Vol.4 (5), p.807-818</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-c6d4c2f5a28be2775670cd62beac5973143a437157031efd77f1a668c54086863</citedby><cites>FETCH-LOGICAL-c303t-c6d4c2f5a28be2775670cd62beac5973143a437157031efd77f1a668c54086863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/089684119190175C$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1797028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itoh, Naoto</creatorcontrib><creatorcontrib>Hanafusa, Toshiaki</creatorcontrib><creatorcontrib>Katsura, Hayato</creatorcontrib><creatorcontrib>Yamamoto, Koji</creatorcontrib><creatorcontrib>Takeda, Akira</creatorcontrib><creatorcontrib>Kurahashi, Akio</creatorcontrib><creatorcontrib>Nabika, Tadashi</creatorcontrib><creatorcontrib>Miyazaki, Atsushi</creatorcontrib><creatorcontrib>Miyagawa, Jun-ichiro</creatorcontrib><creatorcontrib>Kono, Norio</creatorcontrib><creatorcontrib>Tarui, Seiichiro</creatorcontrib><title>Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications</title><title>Journal of autoimmunity</title><addtitle>J Autoimmun</addtitle><description>Complement-fixing adrenal medullary antibodies were examined in sera from 170 (114 Type 1 and 56 Type 2) diabetic patients and normal subjects by indirect immunofluorescence methods. Two types of antibodies were detected; one showed a homogeneous immunofluorescence pattern (homogeneous-type) and the other a spotty pattern (spotty-type) in the cytoplasm of adrenal medullary cells. Both antibodies were IgG class and adrenal medulla-specific. The prevalence of the homogeneous-type was significantly higher in Type 1 diabetic patients with disease duration under 1 year (36%) than in those with duration of 1 year or more (1.1%), in Type 2 diabetic patients (1.8%) or in normal subjects (0%;
P <0.01). Conversely, the prevalence of the spotty-type was not significantly different among all subjects examined (3.6–4.5%). The epitope for the homogeneous-type is likely to be a glycoconjugate since binding of this antibody was abolished after periodate oxidation. The epitope for spotty-type antibody is considered to be a peptide since it was trypsin sensitive. Patients who were positive for the homogeneous-type were also positive for islet cell antibodies, although their antibody titers were not correlated. We conclude that (1) adrenal medullary antibodies are of homogeneous-type or spotty-type and the antigenic determinants of these antibodies are different, and (2) the prevalence of the homogeneous-type is significantly higher in newly diagnosed Type 1 diabetic patients and its presence is associated with that of islet cell antibodies.</description><subject>Adolescent</subject><subject>Adrenal Medulla - immunology</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibody Specificity</subject><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - immunology</subject><subject>Child, Preschool</subject><subject>Complement System Proteins - immunology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetic Neuropathies - immunology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0896-8411</issn><issn>1095-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-LFiEUxiWK7d2tb1DgVexCUzqOOu5FEC_bH1ioi7drcfQMGL46qbOxn6KvnMO71F2BIJzzPOfo70HoBSVvKKHiLRmV6MaB0ktFrxShknf7R2hHieKdolw-Rrs_kqfovJTvhFDKOT9DZ1QqSfpxh34dfiZc7xcoOM3YrDWZWP2UnG-VmrBxGaIJ-AhuDcHke2whhIJ9xIfmwhRf-ljW4GPnYIHoINYr7LyZoHqLF1N9q5Rr_DXDnQkQLbzGS04L5LqtMNFhf1yCt02ZYnmGnswmFHj-cF-gbx9uDvtP3e2Xj5_37287ywirnRVusP3MTT9O0EvJhSTWiX4CY7mSjA7MDEw2CoRRmJ2UMzVCjJYPZBSjYBfo1Wlue8uPFUrVR1-2r5kIaS1a9kL2iqn_CqkgDTDrm3A4CW1OpWSY9ZL9sRHTlOgtML2lobc0tGpnC0zvm-3lw_x1apD_mk4Jtf67Ux8ajTsPWRfrN4zOZ7BVu-T_veA3Qmimkw</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Itoh, Naoto</creator><creator>Hanafusa, Toshiaki</creator><creator>Katsura, Hayato</creator><creator>Yamamoto, Koji</creator><creator>Takeda, Akira</creator><creator>Kurahashi, Akio</creator><creator>Nabika, Tadashi</creator><creator>Miyazaki, Atsushi</creator><creator>Miyagawa, Jun-ichiro</creator><creator>Kono, Norio</creator><creator>Tarui, Seiichiro</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199110</creationdate><title>Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications</title><author>Itoh, Naoto ; Hanafusa, Toshiaki ; Katsura, Hayato ; Yamamoto, Koji ; Takeda, Akira ; Kurahashi, Akio ; Nabika, Tadashi ; Miyazaki, Atsushi ; Miyagawa, Jun-ichiro ; Kono, Norio ; Tarui, Seiichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-c6d4c2f5a28be2775670cd62beac5973143a437157031efd77f1a668c54086863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Adrenal Medulla - immunology</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibody Specificity</topic><topic>Autoantibodies - analysis</topic><topic>Autoantibodies - immunology</topic><topic>Child, Preschool</topic><topic>Complement System Proteins - immunology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetic Neuropathies - immunology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Itoh, Naoto</creatorcontrib><creatorcontrib>Hanafusa, Toshiaki</creatorcontrib><creatorcontrib>Katsura, Hayato</creatorcontrib><creatorcontrib>Yamamoto, Koji</creatorcontrib><creatorcontrib>Takeda, Akira</creatorcontrib><creatorcontrib>Kurahashi, Akio</creatorcontrib><creatorcontrib>Nabika, Tadashi</creatorcontrib><creatorcontrib>Miyazaki, Atsushi</creatorcontrib><creatorcontrib>Miyagawa, Jun-ichiro</creatorcontrib><creatorcontrib>Kono, Norio</creatorcontrib><creatorcontrib>Tarui, Seiichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of autoimmunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Itoh, Naoto</au><au>Hanafusa, Toshiaki</au><au>Katsura, Hayato</au><au>Yamamoto, Koji</au><au>Takeda, Akira</au><au>Kurahashi, Akio</au><au>Nabika, Tadashi</au><au>Miyazaki, Atsushi</au><au>Miyagawa, Jun-ichiro</au><au>Kono, Norio</au><au>Tarui, Seiichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications</atitle><jtitle>Journal of autoimmunity</jtitle><addtitle>J Autoimmun</addtitle><date>1991-10</date><risdate>1991</risdate><volume>4</volume><issue>5</issue><spage>807</spage><epage>818</epage><pages>807-818</pages><issn>0896-8411</issn><eissn>1095-9157</eissn><abstract>Complement-fixing adrenal medullary antibodies were examined in sera from 170 (114 Type 1 and 56 Type 2) diabetic patients and normal subjects by indirect immunofluorescence methods. Two types of antibodies were detected; one showed a homogeneous immunofluorescence pattern (homogeneous-type) and the other a spotty pattern (spotty-type) in the cytoplasm of adrenal medullary cells. Both antibodies were IgG class and adrenal medulla-specific. The prevalence of the homogeneous-type was significantly higher in Type 1 diabetic patients with disease duration under 1 year (36%) than in those with duration of 1 year or more (1.1%), in Type 2 diabetic patients (1.8%) or in normal subjects (0%;
P <0.01). Conversely, the prevalence of the spotty-type was not significantly different among all subjects examined (3.6–4.5%). The epitope for the homogeneous-type is likely to be a glycoconjugate since binding of this antibody was abolished after periodate oxidation. The epitope for spotty-type antibody is considered to be a peptide since it was trypsin sensitive. Patients who were positive for the homogeneous-type were also positive for islet cell antibodies, although their antibody titers were not correlated. We conclude that (1) adrenal medullary antibodies are of homogeneous-type or spotty-type and the antigenic determinants of these antibodies are different, and (2) the prevalence of the homogeneous-type is significantly higher in newly diagnosed Type 1 diabetic patients and its presence is associated with that of islet cell antibodies.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>1797028</pmid><doi>10.1016/0896-8411(91)90175-C</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-8411 |
| ispartof | Journal of autoimmunity, 1991-10, Vol.4 (5), p.807-818 |
| issn | 0896-8411 1095-9157 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72672939 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adrenal Medulla - immunology Adult Aged Antibody Specificity Autoantibodies - analysis Autoantibodies - immunology Child, Preschool Complement System Proteins - immunology Diabetes Mellitus, Type 1 - immunology Diabetic Neuropathies - immunology Female Fluorescent Antibody Technique Humans Immunoglobulin G - analysis Infant Male Middle Aged |
| title | Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: Prevalence, properties and implications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T20%3A56%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20types%20of%20autoantibodies%20to%20adrenal%20medullary%20cells%20in%20Type%201%20(insulin-dependent)%20diabetic%20patients:%20Prevalence,%20properties%20and%20implications&rft.jtitle=Journal%20of%20autoimmunity&rft.au=Itoh,%20Naoto&rft.date=1991-10&rft.volume=4&rft.issue=5&rft.spage=807&rft.epage=818&rft.pages=807-818&rft.issn=0896-8411&rft.eissn=1095-9157&rft_id=info:doi/10.1016/0896-8411(91)90175-C&rft_dat=%3Cproquest_cross%3E16084132%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16084132&rft_id=info:pmid/1797028&rft_els_id=089684119190175C&rfr_iscdi=true |