Ursolic Acid as a Trypanocidal Constituent in Rosemary
The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activity-guided fractionation of the MeOH extract has resulted in the isolation of three tr...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(11), pp.1485-1487 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | Abe, Fumiko Yamauchi, Tatsuo Nagao, Tsuneatsu Kinjo, Junei Okabe, Hikaru Higo, Hiroo Akahane, Hiroshige |
| description | The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T. cruzi epimastigotes at the minimum concentration (MC100) of 40 μg/ml (88 μM) after 48 h of incubation. Oleanolic acid was less active (MC100: 250 μg/ml, 550 μM) and betulinic acid was practically inactive. |
| doi_str_mv | 10.1248/bpb.25.1485 |
| format | Article |
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Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T. cruzi epimastigotes at the minimum concentration (MC100) of 40 μg/ml (88 μM) after 48 h of incubation. Oleanolic acid was less active (MC100: 250 μg/ml, 550 μM) and betulinic acid was practically inactive.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.1485</identifier><identifier>PMID: 12419966</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; betulinic acid ; Biological and medical sciences ; General pharmacology ; Humans ; Medical sciences ; oleanolic acid ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Rosmarinus - chemistry ; Rosmarinus officinalis ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; trypanocidal activity ; Trypanocidal Agents - chemistry ; Trypanocidal Agents - isolation & purification ; Trypanocidal Agents - pharmacology ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - growth & development ; Trypanosoma cruzi - isolation & purification ; Ursolic Acid</subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(11), pp.1485-1487</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-b4c66c579f67ec991822fc4a8ddac2d42e62af3707f958093cb951a343bc07c83</citedby><cites>FETCH-LOGICAL-c655t-b4c66c579f67ec991822fc4a8ddac2d42e62af3707f958093cb951a343bc07c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14366018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12419966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Fumiko</creatorcontrib><creatorcontrib>Yamauchi, Tatsuo</creatorcontrib><creatorcontrib>Nagao, Tsuneatsu</creatorcontrib><creatorcontrib>Kinjo, Junei</creatorcontrib><creatorcontrib>Okabe, Hikaru</creatorcontrib><creatorcontrib>Higo, Hiroo</creatorcontrib><creatorcontrib>Akahane, Hiroshige</creatorcontrib><title>Ursolic Acid as a Trypanocidal Constituent in Rosemary</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T. cruzi epimastigotes at the minimum concentration (MC100) of 40 μg/ml (88 μM) after 48 h of incubation. Oleanolic acid was less active (MC100: 250 μg/ml, 550 μM) and betulinic acid was practically inactive.</description><subject>Animals</subject><subject>betulinic acid</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>oleanolic acid</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Rosmarinus - chemistry</subject><subject>Rosmarinus officinalis</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>trypanocidal activity</subject><subject>Trypanocidal Agents - chemistry</subject><subject>Trypanocidal Agents - isolation & purification</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - growth & development</subject><subject>Trypanosoma cruzi - isolation & purification</subject><subject>Ursolic Acid</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLxDAQB_Agiq6Pk3cpiF6ka95pjuviCwRB9Bym01S7dNs1aQ9-e1u2rOAlIeSXmcmfkHNG54zL7Dbf5HOu5kxmao_MmJAmVZypfTKjlmWpZio7IscxriilhnJxSI6Gd8xarWdEf4TY1hUmC6yKBGICyXv42UDTDmeok2XbxK7qet90SdUkb230awg_p-SghDr6s2k_IR8P9-_Lp_Tl9fF5uXhJUSvVpblErVEZW2rj0Q7jcF6ihKwoAHkhudccSmGoKa3KqBWYW8VASJEjNZiJE3K9rbsJ7XfvY-fWVURf19D4to_OcG2oUiO8_AdXbR-aYTbHpLTMUsPYoG62CkMbY_Cl24Rq_I9j1I1huiFMx5Ubwxz0xVSzz9e--LNTegO4mgBEhLoM0GAV_5wUWlM2Dne3davYwaffAQhdhbXfNWXTOnbfXeIXBOcb8Qv87ZIB</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Abe, Fumiko</creator><creator>Yamauchi, Tatsuo</creator><creator>Nagao, Tsuneatsu</creator><creator>Kinjo, Junei</creator><creator>Okabe, Hikaru</creator><creator>Higo, Hiroo</creator><creator>Akahane, Hiroshige</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Ursolic Acid as a Trypanocidal Constituent in Rosemary</title><author>Abe, Fumiko ; Yamauchi, Tatsuo ; Nagao, Tsuneatsu ; Kinjo, Junei ; Okabe, Hikaru ; Higo, Hiroo ; Akahane, Hiroshige</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-b4c66c579f67ec991822fc4a8ddac2d42e62af3707f958093cb951a343bc07c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>betulinic acid</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>oleanolic acid</topic><topic>Pharmacognosy. 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Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T. cruzi epimastigotes at the minimum concentration (MC100) of 40 μg/ml (88 μM) after 48 h of incubation. Oleanolic acid was less active (MC100: 250 μg/ml, 550 μM) and betulinic acid was practically inactive.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>12419966</pmid><doi>10.1248/bpb.25.1485</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals betulinic acid Biological and medical sciences General pharmacology Humans Medical sciences oleanolic acid Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Rosmarinus - chemistry Rosmarinus officinalis Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology trypanocidal activity Trypanocidal Agents - chemistry Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development Trypanosoma cruzi - isolation & purification Ursolic Acid |
| title | Ursolic Acid as a Trypanocidal Constituent in Rosemary |
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