Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake
Recent studies have shown the existence of two important inhibitory mechanisms for the control of NaCl and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on α 2-adrenergic/imidazoline receptors probably in the forebrain areas. In the p...
Gespeichert in:
| Veröffentlicht in: | Brain research 2002-11, Vol.956 (1), p.103-109 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109 |
|---|---|
| container_issue | 1 |
| container_start_page | 103 |
| container_title | Brain research |
| container_volume | 956 |
| creator | Oliveira Margatho, Lisandra Pereira Barbosa, Silas Antonio De Luca, Laurival Vanderlei Menani, José |
| description | Recent studies have shown the existence of two important inhibitory mechanisms for the control of NaCl and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on α
2-adrenergic/imidazoline receptors probably in the forebrain areas. In the present study we investigated if α
2-adrenergic/imidazoline and serotonergic inhibitory mechanisms interact to control NaCl and water intake. Male Holtzman rats with cannulas implanted simultaneously into the lateral ventricle (LV) and bilaterally into the LPBN were used. The ingestion of 0.3 M NaCl and water was induced by treatment with the diuretic furosemide (10 mg/kg of body weight)+the angiotensin converting enzyme inhibitor captopril (5 mg/kg) injected subcutaneously 1 h before the access of rats to water and 0.3 M NaCl. Intracerebroventricular (i.c.v.) injection of the α
2-adrenergic/imidazoline agonist clonidine (20 nmol/1 μl) almost abolished water (1.6±1.2, vs. vehicle: 7.5±2.2 ml/2 h) and 0.3 M NaCl intake (0.5±0.3, vs. vehicle: 2.2±0.8 ml/2 h). Similar effects were produced by bilateral injections of the 5HT
2a/2c serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (DOI, 5 μg/0.2 μl each site) into the LPBN on water (3.6±0.9 ml/2 h) and 0.3 M NaCl intake (0.4±0.2 ml/2 h). Injection of the α
2-adrenergic/imidazoline antagonist idazoxan (320 nmol) i.c.v. completely blocked the effects of clonidine on water (8.4±1.5 ml/2 h) and NaCl intake (4.0±1.2 ml/2 h), but did not change the effects of LPBN injections of DOI on water (4.2±1.0 ml/2 h) and NaCl intake (0.7±0.2 ml/2 h). Bilateral injections of methysergide (4 μg/0.2 μl each site) into the LPBN increased 0.3 M NaCl intake (6.4±1.9 ml/2 h), not water intake. The inhibitory effect of i.c.v. clonidine on water and 0.3 M NaCl was still present after injections of methysergide into the LPBN (1.5±0.8 and 1.7±1.4 ml/2 h, respectively). The results show that the inhibitory effects of the activation of α
2-adrenergic/imidazoline receptors in the forebrain are still present after blockade of the LPBN serotonergic mechanisms and vice versa for the activation of serotonergic mechanisms of the LPBN. Therefore, each system may act independently to inhibit NaCl and water intake. |
| doi_str_mv | 10.1016/S0006-8993(02)03486-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72669044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899302034868</els_id><sourcerecordid>18616028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-58980005c5f57ec23259483d136e342cac533352f11a374ba55696a9145258de3</originalsourceid><addsrcrecordid>eNqFkUtvFDEQhK0IlGwCPyHRXIjCYYjfY5-iaMVLisQBOJteuydxmLGDPQsKv57Zh8gxp1ZJX3W3qgg5ZfQdo0xffqWU6tZYKy4of0uFNLM6IAtmOt5qLukLsviPHJHjWu9nKYSlh-SIcck1VXxBfiwxTQWGpmLJU05YbqNvIIUGQsGdvIxjDPA3DzFhE9NdXMUpl8dmRH8HKdaxNjk1NYe4HrfWPzBhmckJfuIr8rKHoeLr_Twh3z-8_7b81N58-fh5eX3TemnM1Cpjzfyf8qpXHXouuLLSiMCERiG5B6-EEIr3jIHo5AqU0laDZVJxZQKKE3K-2_tQ8q811smNsXocBkiY19V1XGtLpXwWZEYzTbmZQbUDfcm1FuzdQ4kjlEfHqNt04LYduE3AjnK37cBtfGf7A-vViOHJtQ99Bt7sAagehr5A8rE-cZJS22k1c1c7DufcfkcsrvqIyWOIBf3kQo7PvPIPyiKi2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18616028</pqid></control><display><type>article</type><title>Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Oliveira Margatho, Lisandra ; Pereira Barbosa, Silas ; Antonio De Luca, Laurival ; Vanderlei Menani, José</creator><creatorcontrib>Oliveira Margatho, Lisandra ; Pereira Barbosa, Silas ; Antonio De Luca, Laurival ; Vanderlei Menani, José</creatorcontrib><description>Recent studies have shown the existence of two important inhibitory mechanisms for the control of NaCl and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on α
2-adrenergic/imidazoline receptors probably in the forebrain areas. In the present study we investigated if α
2-adrenergic/imidazoline and serotonergic inhibitory mechanisms interact to control NaCl and water intake. Male Holtzman rats with cannulas implanted simultaneously into the lateral ventricle (LV) and bilaterally into the LPBN were used. The ingestion of 0.3 M NaCl and water was induced by treatment with the diuretic furosemide (10 mg/kg of body weight)+the angiotensin converting enzyme inhibitor captopril (5 mg/kg) injected subcutaneously 1 h before the access of rats to water and 0.3 M NaCl. Intracerebroventricular (i.c.v.) injection of the α
2-adrenergic/imidazoline agonist clonidine (20 nmol/1 μl) almost abolished water (1.6±1.2, vs. vehicle: 7.5±2.2 ml/2 h) and 0.3 M NaCl intake (0.5±0.3, vs. vehicle: 2.2±0.8 ml/2 h). Similar effects were produced by bilateral injections of the 5HT
2a/2c serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (DOI, 5 μg/0.2 μl each site) into the LPBN on water (3.6±0.9 ml/2 h) and 0.3 M NaCl intake (0.4±0.2 ml/2 h). Injection of the α
2-adrenergic/imidazoline antagonist idazoxan (320 nmol) i.c.v. completely blocked the effects of clonidine on water (8.4±1.5 ml/2 h) and NaCl intake (4.0±1.2 ml/2 h), but did not change the effects of LPBN injections of DOI on water (4.2±1.0 ml/2 h) and NaCl intake (0.7±0.2 ml/2 h). Bilateral injections of methysergide (4 μg/0.2 μl each site) into the LPBN increased 0.3 M NaCl intake (6.4±1.9 ml/2 h), not water intake. The inhibitory effect of i.c.v. clonidine on water and 0.3 M NaCl was still present after injections of methysergide into the LPBN (1.5±0.8 and 1.7±1.4 ml/2 h, respectively). The results show that the inhibitory effects of the activation of α
2-adrenergic/imidazoline receptors in the forebrain are still present after blockade of the LPBN serotonergic mechanisms and vice versa for the activation of serotonergic mechanisms of the LPBN. Therefore, each system may act independently to inhibit NaCl and water intake.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(02)03486-8</identifier><identifier>PMID: 12426052</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject><![CDATA[Amphetamines - administration & dosage ; Amphetamines - pharmacology ; Angiotensin II ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Biological and medical sciences ; Captopril - pharmacology ; Cerebellar Nuclei - drug effects ; Cerebellar Nuclei - physiology ; Clonidine ; Clonidine - administration & dosage ; Clonidine - pharmacology ; Diuretics - pharmacology ; Drinking - drug effects ; Drinking - physiology ; Drinking Behavior - drug effects ; Drinking Behavior - physiology ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Furosemide - pharmacology ; Idazoxan - administration & dosage ; Idazoxan - pharmacology ; Imidazoline Receptors ; Injections, Intraventricular ; Male ; Methysergide - administration & dosage ; Methysergide - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Drug - physiology ; Receptors, Serotonin - physiology ; Serotonin ; Serotonin Antagonists - administration & dosage ; Serotonin Antagonists - pharmacology ; Serotonin Receptor Agonists - administration & dosage ; Serotonin Receptor Agonists - pharmacology ; Sodium appetite ; Sodium Chloride, Dietary ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; α 2-Adrenergic receptor]]></subject><ispartof>Brain research, 2002-11, Vol.956 (1), p.103-109</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-58980005c5f57ec23259483d136e342cac533352f11a374ba55696a9145258de3</citedby><cites>FETCH-LOGICAL-c488t-58980005c5f57ec23259483d136e342cac533352f11a374ba55696a9145258de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(02)03486-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14009765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12426052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira Margatho, Lisandra</creatorcontrib><creatorcontrib>Pereira Barbosa, Silas</creatorcontrib><creatorcontrib>Antonio De Luca, Laurival</creatorcontrib><creatorcontrib>Vanderlei Menani, José</creatorcontrib><title>Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Recent studies have shown the existence of two important inhibitory mechanisms for the control of NaCl and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on α
2-adrenergic/imidazoline receptors probably in the forebrain areas. In the present study we investigated if α
2-adrenergic/imidazoline and serotonergic inhibitory mechanisms interact to control NaCl and water intake. Male Holtzman rats with cannulas implanted simultaneously into the lateral ventricle (LV) and bilaterally into the LPBN were used. The ingestion of 0.3 M NaCl and water was induced by treatment with the diuretic furosemide (10 mg/kg of body weight)+the angiotensin converting enzyme inhibitor captopril (5 mg/kg) injected subcutaneously 1 h before the access of rats to water and 0.3 M NaCl. Intracerebroventricular (i.c.v.) injection of the α
2-adrenergic/imidazoline agonist clonidine (20 nmol/1 μl) almost abolished water (1.6±1.2, vs. vehicle: 7.5±2.2 ml/2 h) and 0.3 M NaCl intake (0.5±0.3, vs. vehicle: 2.2±0.8 ml/2 h). Similar effects were produced by bilateral injections of the 5HT
2a/2c serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (DOI, 5 μg/0.2 μl each site) into the LPBN on water (3.6±0.9 ml/2 h) and 0.3 M NaCl intake (0.4±0.2 ml/2 h). Injection of the α
2-adrenergic/imidazoline antagonist idazoxan (320 nmol) i.c.v. completely blocked the effects of clonidine on water (8.4±1.5 ml/2 h) and NaCl intake (4.0±1.2 ml/2 h), but did not change the effects of LPBN injections of DOI on water (4.2±1.0 ml/2 h) and NaCl intake (0.7±0.2 ml/2 h). Bilateral injections of methysergide (4 μg/0.2 μl each site) into the LPBN increased 0.3 M NaCl intake (6.4±1.9 ml/2 h), not water intake. The inhibitory effect of i.c.v. clonidine on water and 0.3 M NaCl was still present after injections of methysergide into the LPBN (1.5±0.8 and 1.7±1.4 ml/2 h, respectively). The results show that the inhibitory effects of the activation of α
2-adrenergic/imidazoline receptors in the forebrain are still present after blockade of the LPBN serotonergic mechanisms and vice versa for the activation of serotonergic mechanisms of the LPBN. Therefore, each system may act independently to inhibit NaCl and water intake.</description><subject>Amphetamines - administration & dosage</subject><subject>Amphetamines - pharmacology</subject><subject>Angiotensin II</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Captopril - pharmacology</subject><subject>Cerebellar Nuclei - drug effects</subject><subject>Cerebellar Nuclei - physiology</subject><subject>Clonidine</subject><subject>Clonidine - administration & dosage</subject><subject>Clonidine - pharmacology</subject><subject>Diuretics - pharmacology</subject><subject>Drinking - drug effects</subject><subject>Drinking - physiology</subject><subject>Drinking Behavior - drug effects</subject><subject>Drinking Behavior - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Furosemide - pharmacology</subject><subject>Idazoxan - administration & dosage</subject><subject>Idazoxan - pharmacology</subject><subject>Imidazoline Receptors</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Methysergide - administration & dosage</subject><subject>Methysergide - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Drug - physiology</subject><subject>Receptors, Serotonin - physiology</subject><subject>Serotonin</subject><subject>Serotonin Antagonists - administration & dosage</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotonin Receptor Agonists - administration & dosage</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>Sodium appetite</subject><subject>Sodium Chloride, Dietary</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>α 2-Adrenergic receptor</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFDEQhK0IlGwCPyHRXIjCYYjfY5-iaMVLisQBOJteuydxmLGDPQsKv57Zh8gxp1ZJX3W3qgg5ZfQdo0xffqWU6tZYKy4of0uFNLM6IAtmOt5qLukLsviPHJHjWu9nKYSlh-SIcck1VXxBfiwxTQWGpmLJU05YbqNvIIUGQsGdvIxjDPA3DzFhE9NdXMUpl8dmRH8HKdaxNjk1NYe4HrfWPzBhmckJfuIr8rKHoeLr_Twh3z-8_7b81N58-fh5eX3TemnM1Cpjzfyf8qpXHXouuLLSiMCERiG5B6-EEIr3jIHo5AqU0laDZVJxZQKKE3K-2_tQ8q811smNsXocBkiY19V1XGtLpXwWZEYzTbmZQbUDfcm1FuzdQ4kjlEfHqNt04LYduE3AjnK37cBtfGf7A-vViOHJtQ99Bt7sAagehr5A8rE-cZJS22k1c1c7DufcfkcsrvqIyWOIBf3kQo7PvPIPyiKi2A</recordid><startdate>20021122</startdate><enddate>20021122</enddate><creator>Oliveira Margatho, Lisandra</creator><creator>Pereira Barbosa, Silas</creator><creator>Antonio De Luca, Laurival</creator><creator>Vanderlei Menani, José</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20021122</creationdate><title>Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake</title><author>Oliveira Margatho, Lisandra ; Pereira Barbosa, Silas ; Antonio De Luca, Laurival ; Vanderlei Menani, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-58980005c5f57ec23259483d136e342cac533352f11a374ba55696a9145258de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amphetamines - administration & dosage</topic><topic>Amphetamines - pharmacology</topic><topic>Angiotensin II</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Captopril - pharmacology</topic><topic>Cerebellar Nuclei - drug effects</topic><topic>Cerebellar Nuclei - physiology</topic><topic>Clonidine</topic><topic>Clonidine - administration & dosage</topic><topic>Clonidine - pharmacology</topic><topic>Diuretics - pharmacology</topic><topic>Drinking - drug effects</topic><topic>Drinking - physiology</topic><topic>Drinking Behavior - drug effects</topic><topic>Drinking Behavior - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Furosemide - pharmacology</topic><topic>Idazoxan - administration & dosage</topic><topic>Idazoxan - pharmacology</topic><topic>Imidazoline Receptors</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Methysergide - administration & dosage</topic><topic>Methysergide - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Drug - physiology</topic><topic>Receptors, Serotonin - physiology</topic><topic>Serotonin</topic><topic>Serotonin Antagonists - administration & dosage</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotonin Receptor Agonists - administration & dosage</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>Sodium appetite</topic><topic>Sodium Chloride, Dietary</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>α 2-Adrenergic receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira Margatho, Lisandra</creatorcontrib><creatorcontrib>Pereira Barbosa, Silas</creatorcontrib><creatorcontrib>Antonio De Luca, Laurival</creatorcontrib><creatorcontrib>Vanderlei Menani, José</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira Margatho, Lisandra</au><au>Pereira Barbosa, Silas</au><au>Antonio De Luca, Laurival</au><au>Vanderlei Menani, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2002-11-22</date><risdate>2002</risdate><volume>956</volume><issue>1</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Recent studies have shown the existence of two important inhibitory mechanisms for the control of NaCl and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on α
2-adrenergic/imidazoline receptors probably in the forebrain areas. In the present study we investigated if α
2-adrenergic/imidazoline and serotonergic inhibitory mechanisms interact to control NaCl and water intake. Male Holtzman rats with cannulas implanted simultaneously into the lateral ventricle (LV) and bilaterally into the LPBN were used. The ingestion of 0.3 M NaCl and water was induced by treatment with the diuretic furosemide (10 mg/kg of body weight)+the angiotensin converting enzyme inhibitor captopril (5 mg/kg) injected subcutaneously 1 h before the access of rats to water and 0.3 M NaCl. Intracerebroventricular (i.c.v.) injection of the α
2-adrenergic/imidazoline agonist clonidine (20 nmol/1 μl) almost abolished water (1.6±1.2, vs. vehicle: 7.5±2.2 ml/2 h) and 0.3 M NaCl intake (0.5±0.3, vs. vehicle: 2.2±0.8 ml/2 h). Similar effects were produced by bilateral injections of the 5HT
2a/2c serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (DOI, 5 μg/0.2 μl each site) into the LPBN on water (3.6±0.9 ml/2 h) and 0.3 M NaCl intake (0.4±0.2 ml/2 h). Injection of the α
2-adrenergic/imidazoline antagonist idazoxan (320 nmol) i.c.v. completely blocked the effects of clonidine on water (8.4±1.5 ml/2 h) and NaCl intake (4.0±1.2 ml/2 h), but did not change the effects of LPBN injections of DOI on water (4.2±1.0 ml/2 h) and NaCl intake (0.7±0.2 ml/2 h). Bilateral injections of methysergide (4 μg/0.2 μl each site) into the LPBN increased 0.3 M NaCl intake (6.4±1.9 ml/2 h), not water intake. The inhibitory effect of i.c.v. clonidine on water and 0.3 M NaCl was still present after injections of methysergide into the LPBN (1.5±0.8 and 1.7±1.4 ml/2 h, respectively). The results show that the inhibitory effects of the activation of α
2-adrenergic/imidazoline receptors in the forebrain are still present after blockade of the LPBN serotonergic mechanisms and vice versa for the activation of serotonergic mechanisms of the LPBN. Therefore, each system may act independently to inhibit NaCl and water intake.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>12426052</pmid><doi>10.1016/S0006-8993(02)03486-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2002-11, Vol.956 (1), p.103-109 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72669044 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Amphetamines - administration & dosage Amphetamines - pharmacology Angiotensin II Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Captopril - pharmacology Cerebellar Nuclei - drug effects Cerebellar Nuclei - physiology Clonidine Clonidine - administration & dosage Clonidine - pharmacology Diuretics - pharmacology Drinking - drug effects Drinking - physiology Drinking Behavior - drug effects Drinking Behavior - physiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Furosemide - pharmacology Idazoxan - administration & dosage Idazoxan - pharmacology Imidazoline Receptors Injections, Intraventricular Male Methysergide - administration & dosage Methysergide - pharmacology Rats Rats, Sprague-Dawley Receptors, Drug - physiology Receptors, Serotonin - physiology Serotonin Serotonin Antagonists - administration & dosage Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - administration & dosage Serotonin Receptor Agonists - pharmacology Sodium appetite Sodium Chloride, Dietary Vertebrates: anatomy and physiology, studies on body, several organs or systems α 2-Adrenergic receptor |
| title | Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T06%3A02%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Central%20serotonergic%20and%20adrenergic/imidazoline%20inhibitory%20mechanisms%20on%20sodium%20and%20water%20intake&rft.jtitle=Brain%20research&rft.au=Oliveira%20Margatho,%20Lisandra&rft.date=2002-11-22&rft.volume=956&rft.issue=1&rft.spage=103&rft.epage=109&rft.pages=103-109&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/S0006-8993(02)03486-8&rft_dat=%3Cproquest_cross%3E18616028%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18616028&rft_id=info:pmid/12426052&rft_els_id=S0006899302034868&rfr_iscdi=true |