Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues
It is known that some derivatives of both thiourea and thiosemicarbazide exhibit potent anti-microbial activity. In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In thi...
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| Veröffentlicht in: | Farmaco (Società chimica italiana : 1989) 2002-10, Vol.57 (10), p.809-817 |
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| container_title | Farmaco (Società chimica italiana : 1989) |
| container_volume | 57 |
| creator | Maccioni, E Cardia, M.C Bonsignore, L Plumitallo, A Pellerano, M.L De Logu, A |
| description | It is known that some derivatives of both thiourea and thiosemicarbazide exhibit potent anti-microbial activity. In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure–activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring. |
| doi_str_mv | 10.1016/S0014-827X(02)01288-0 |
| format | Article |
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In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure–activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring.</description><identifier>ISSN: 0014-827X</identifier><identifier>EISSN: 1879-0569</identifier><identifier>DOI: 10.1016/S0014-827X(02)01288-0</identifier><identifier>PMID: 12420876</identifier><language>eng</language><publisher>Lausanne: Elsevier SAS</publisher><subject>Animals ; Anti-Bacterial Agents ; Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. 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In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure–activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring.</description><subject>Animals</subject><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Biological activity</subject><subject>Biological and medical sciences</subject><subject>Cercopithecus aethiops</subject><subject>Fungi - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Isothiosemicarbazones</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Structure-Activity Relationship</subject><subject>Thiazole</subject><subject>Thiosemicarbazones - chemistry</subject><subject>Thiosemicarbazones - pharmacology</subject><subject>Vero Cells - drug effects</subject><issn>0014-827X</issn><issn>1879-0569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BGUvih6qk7RN2pOI-AWCh1XwFtLpRCPdRpOusP56s-6iRw8hCXnemczD2D6HUw5cnk0AeJFVQj0fgzgBLqoqgzU24pWqMyhlvc5Gv8gW247xLV2VkmqTbXFRCKiUHLHJZN4PrxRdHJu-TWtw2dRh8I0z3djg4D7dMB97O3bRD6_OR0rPJjTmy_e0DOEcO4fpaDr_MqO4yzas6SLtrfYd9nR99Xh5m90_3NxdXtxnmNd8yGRFqkYLjbIFlJaUNE1uyRoEsC3mqiUoihJNI3hBBSlegVUcqSgFiUbkO-xoWfc9-I_Ud9BTF5G6zvTkZ1ErIWUaEhJYLsE0V4yBrH4PbmrCXHPQC5v6x6ZeqNIg9I9NvcgdrBrMmim1f6mVvgQcrgAT0XQ2mB5d_OPyWsmqVIk7X3KUdHw6Cjqiox6pdYFw0K13_3zlG0h4k5w</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Maccioni, E</creator><creator>Cardia, M.C</creator><creator>Bonsignore, L</creator><creator>Plumitallo, A</creator><creator>Pellerano, M.L</creator><creator>De Logu, A</creator><general>Elsevier SAS</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues</title><author>Maccioni, E ; Cardia, M.C ; Bonsignore, L ; Plumitallo, A ; Pellerano, M.L ; De Logu, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-68e79cf0b7f405fe76ab3fefac00fdc37de0445cab214e4e7180f71ce452e2b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents</topic><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. 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In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure–activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring.</abstract><cop>Lausanne</cop><pub>Elsevier SAS</pub><pmid>12420876</pmid><doi>10.1016/S0014-827X(02)01288-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | Farmaco (Società chimica italiana : 1989), 2002-10, Vol.57 (10), p.809-817 |
| issn | 0014-827X 1879-0569 |
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| subjects | Animals Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological activity Biological and medical sciences Cercopithecus aethiops Fungi - drug effects Gram-Positive Bacteria - drug effects Hydrophobic and Hydrophilic Interactions Isothiosemicarbazones Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Thiazole Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology Vero Cells - drug effects |
| title | Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues |
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