Studies on Antiatherosclerotic Agents. Synthesis and Inhibitory Activities on Platelet Aggregation of 4-Aryl Derivatives of 7-Ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone

4-Aryl derivatives of 7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone and related derivatives were newly synthesized in order to test for their inhibitory activities on platelet aggregation. 4-(2-Anisyl) compound and the corresponding 1-chloro derivative demonstrated significant activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/08/25, Vol.39(8), pp.2009-2015
Hauptverfasser:	EGUCHI, Yukuo, SATO, Yuko, SEKIZAKI, Satomi, ISHIKAWA, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(2-anisyl)-7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone Animals Arteriosclerosis - drug therapy arylcadmium reagent Chemistry coupling reaction Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings In Vitro Techniques inhibitory effect Organic chemistry Phthalazines - chemical synthesis Phthalazines - pharmacology platelet aggregation Platelet Aggregation Inhibitors - chemical synthesis Preparations and properties Rabbits synthesis
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Beschreibung
Zusammenfassung:	4-Aryl derivatives of 7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone and related derivatives were newly synthesized in order to test for their inhibitory activities on platelet aggregation. 4-(2-Anisyl) compound and the corresponding 1-chloro derivative demonstrated significant activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.2009