Role of contaminating platelets in thromboxane synthesis in primary cultures of human umbilical vein endothelial cells

Previous studies suggested that cultured human endothelial cells metabolize arachidonic acid to thromboxane A 2. When primary cultures of human umbilical vein endothelial cells were incubated with 14 C -arachidonic acid and the 14 C -metabolites resolved by reverse phase high pressure liquid chromat...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2002-09, Vol.70 (1), p.39-49
Hauptverfasser:	Pfister, Sandra L, Hughes, Miranda J, Rosolowsky, Mark, Campbell, William B
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - biosynthesis Arachidonic Acid - metabolism Blood Platelets - physiology Calcimycin - pharmacology Cells, Cultured Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Histamine Humans Microscopy, Phase-Contrast Platelets Prostacyclin Thromboxane Thromboxane A2 - biosynthesis Umbilical Veins
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