Effects of Some Inorganic Divalent Cations and Protein Kinase C Inhibitors on Endothelium-Dependent Relaxation in Rat Isolated Aorta and Mesenteric Arteries

The effects of nitrendipine and several metal ions possessing Ca antagonistic activity were examined on acetylcholine (ACh) and histamine-induced endothelium-dependent relaxations in norepinephrine (NE)-precontracted rat aortic rings and perfused mesenteric arteries. Nitrendipine (1 nM) profoundly a...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1991-10, Vol.18 (4), p.511-521
Hauptverfasser:	Adeagbo, Ayotunde S. O, Triggle, Christopher R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Acetylcholine - pharmacology Alkaloids - pharmacology Animals Aorta, Thoracic - drug effects Biological and medical sciences Calcium - pharmacology Cardiovascular system Cations, Divalent - pharmacology Endothelium, Vascular - physiology Histamine - pharmacology In Vitro Techniques Isoquinolines - pharmacology Male Medical sciences Mesenteric Arteries - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Nitrendipine - pharmacology Nitroprusside - pharmacology Norepinephrine - pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Protein Kinase C - antagonists & inhibitors Rats Rats, Inbred Strains Staurosporine Vasodilator agents. Cerebral vasodilators
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