Grb2 Is a Key Mediator of Helicobacter pylori CagA Protein Activities

CagA delivered from Helicobacter pylori into gastric epithelial cells undergoes tyrosine phosphorylation and induces host cell morphological changes. Here we show that CagA can interact with Grb2 both in vitro and in vivo, which results in the activation of the Ras/MEK/ERK pathway and leads to cell...

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Veröffentlicht in:	Molecular cell 2002-10, Vol.10 (4), p.745-755
Hauptverfasser:	Mimuro, Hitomi, Suzuki, Toshihiko, Tanaka, Jiro, Asahi, Momoyo, Haas, Rainer, Sasakawa, Chihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Bacterial Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Cell Division Cell Line Cell Movement Cell Size COS Cells GRB2 Adaptor Protein Helicobacter pylori - genetics Helicobacter pylori - metabolism Humans Mutation Phosphorylation Phosphotyrosine - metabolism Protein Binding Proteins - genetics Proteins - metabolism Signal Transduction
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