Lymphoma-associated retinopathy
To describe the clinical, electrophysiologic, and serologic findings in a patient with retinal degeneration associated with Hodgkin’s lymphoma. Case report with ancillary immunohistochemical studies. A 24-year-old woman experienced night blindness and fundus abnormalities 1 week after initiation of...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2002-11, Vol.109 (11), p.2149-2153 |
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| container_title | Ophthalmology (Rochester, Minn.) |
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| creator | To, King W Thirkill, Charles E Jakobiec, Frederick A Lessell, Simmons Berson, Eliot L |
| description | To describe the clinical, electrophysiologic, and serologic findings in a patient with retinal degeneration associated with Hodgkin’s lymphoma.
Case report with ancillary immunohistochemical studies.
A 24-year-old woman experienced night blindness and fundus abnormalities 1 week after initiation of chemotherapy for Hodgkin’s lymphoma. Visual fields and full-field electroretinograms (ERGs) were monitored over a 10-year period. Serum antibodies were studied on Western blot reactions on a solubilized extract of bovine retina. Serum antibodies were also evaluated through indirect immunohistochemistry on rhesus monkey retina.
Visual field and ERG amplitudes, initially abnormal, became reduced further over 10 years. Serum antibodies were identified that reacted to a retinal protein or proteins approximating 65 kd; these antibodies showed immunologic activity against photoreceptors.
A progressive paraneoplastic retinopathy can occur in association with Hodgkin’s lymphoma. The pathogenesis of the retinal degeneration appears to be related to a serum antibody that is reacting to a retinal protein or proteins of approximately 65 kd. |
| doi_str_mv | 10.1016/S0161-6420(02)01261-7 |
| format | Article |
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Case report with ancillary immunohistochemical studies.
A 24-year-old woman experienced night blindness and fundus abnormalities 1 week after initiation of chemotherapy for Hodgkin’s lymphoma. Visual fields and full-field electroretinograms (ERGs) were monitored over a 10-year period. Serum antibodies were studied on Western blot reactions on a solubilized extract of bovine retina. Serum antibodies were also evaluated through indirect immunohistochemistry on rhesus monkey retina.
Visual field and ERG amplitudes, initially abnormal, became reduced further over 10 years. Serum antibodies were identified that reacted to a retinal protein or proteins approximating 65 kd; these antibodies showed immunologic activity against photoreceptors.
A progressive paraneoplastic retinopathy can occur in association with Hodgkin’s lymphoma. The pathogenesis of the retinal degeneration appears to be related to a serum antibody that is reacting to a retinal protein or proteins of approximately 65 kd.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(02)01261-7</identifier><identifier>PMID: 12414431</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Autoantibodies - blood ; Biological and medical sciences ; Blotting, Western ; Electroretinography ; Eye Proteins - immunology ; Female ; Hematologic and hematopoietic diseases ; Hodgkin Disease - complications ; Hodgkin Disease - diagnosis ; Hodgkin Disease - drug therapy ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Night Blindness - etiology ; Ophthalmology ; Paraneoplastic Syndromes - diagnosis ; Paraneoplastic Syndromes - drug therapy ; Paraneoplastic Syndromes - etiology ; Prednisone - therapeutic use ; Retina - immunology ; Retinal Degeneration - diagnosis ; Retinal Degeneration - drug therapy ; Retinal Degeneration - etiology ; Retinopathies ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus ; Visual Acuity ; Visual Fields</subject><ispartof>Ophthalmology (Rochester, Minn.), 2002-11, Vol.109 (11), p.2149-2153</ispartof><rights>2002 American Academy of Ophthalmology, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-4b172c0f61952edeb5fc4730175482cbc7513288648ba4d43690eb08aa589ca43</citedby><cites>FETCH-LOGICAL-c391t-4b172c0f61952edeb5fc4730175482cbc7513288648ba4d43690eb08aa589ca43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161642002012617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14361242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12414431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>To, King W</creatorcontrib><creatorcontrib>Thirkill, Charles E</creatorcontrib><creatorcontrib>Jakobiec, Frederick A</creatorcontrib><creatorcontrib>Lessell, Simmons</creatorcontrib><creatorcontrib>Berson, Eliot L</creatorcontrib><title>Lymphoma-associated retinopathy</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To describe the clinical, electrophysiologic, and serologic findings in a patient with retinal degeneration associated with Hodgkin’s lymphoma.
Case report with ancillary immunohistochemical studies.
A 24-year-old woman experienced night blindness and fundus abnormalities 1 week after initiation of chemotherapy for Hodgkin’s lymphoma. Visual fields and full-field electroretinograms (ERGs) were monitored over a 10-year period. Serum antibodies were studied on Western blot reactions on a solubilized extract of bovine retina. Serum antibodies were also evaluated through indirect immunohistochemistry on rhesus monkey retina.
Visual field and ERG amplitudes, initially abnormal, became reduced further over 10 years. Serum antibodies were identified that reacted to a retinal protein or proteins approximating 65 kd; these antibodies showed immunologic activity against photoreceptors.
A progressive paraneoplastic retinopathy can occur in association with Hodgkin’s lymphoma. The pathogenesis of the retinal degeneration appears to be related to a serum antibody that is reacting to a retinal protein or proteins of approximately 65 kd.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Electroretinography</subject><subject>Eye Proteins - immunology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - complications</subject><subject>Hodgkin Disease - diagnosis</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Night Blindness - etiology</subject><subject>Ophthalmology</subject><subject>Paraneoplastic Syndromes - diagnosis</subject><subject>Paraneoplastic Syndromes - drug therapy</subject><subject>Paraneoplastic Syndromes - etiology</subject><subject>Prednisone - therapeutic use</subject><subject>Retina - immunology</subject><subject>Retinal Degeneration - diagnosis</subject><subject>Retinal Degeneration - drug therapy</subject><subject>Retinal Degeneration - etiology</subject><subject>Retinopathies</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><subject>Visual Acuity</subject><subject>Visual Fields</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotlZ_go-LoofVTDaP3ZNI8QUFD-o5ZLOzNLKPmmyF_nvTdrFHLzMMfPP6CDkFegsU5N17DJBIzug1ZTcUWKzUHhmD4HnCFaT7ZPyHjMhRCF-UUilTfkhGwDhwnsKYnM9WzWLeNSYxIXTWmR7LC4-9a7uF6eerY3JQmTrgyZAn5PPp8WP6kszenl-nD7PEpjn0CS9AMUsrCblgWGIhKstVSkEJnjFbWCUgZVkmeVYYXvJU5hQLmhkjstwank7I1XbuwnffSwy9blywWNemxW4ZtGJSUiGyCIotaH0XgsdKL7xrjF9poHptRm_M6PXbmjK9MaNV7DsbFiyLBstd16AiApcDYII1deVNa13YcfHmyLLI3W85jDp-HHodrMPWYuk82l6XnfvnlF_9WX1j</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>To, King W</creator><creator>Thirkill, Charles E</creator><creator>Jakobiec, Frederick A</creator><creator>Lessell, Simmons</creator><creator>Berson, Eliot L</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Lymphoma-associated retinopathy</title><author>To, King W ; Thirkill, Charles E ; Jakobiec, Frederick A ; Lessell, Simmons ; Berson, Eliot L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-4b172c0f61952edeb5fc4730175482cbc7513288648ba4d43690eb08aa589ca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Electroretinography</topic><topic>Eye Proteins - immunology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin Disease - complications</topic><topic>Hodgkin Disease - diagnosis</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Night Blindness - etiology</topic><topic>Ophthalmology</topic><topic>Paraneoplastic Syndromes - diagnosis</topic><topic>Paraneoplastic Syndromes - drug therapy</topic><topic>Paraneoplastic Syndromes - etiology</topic><topic>Prednisone - therapeutic use</topic><topic>Retina - immunology</topic><topic>Retinal Degeneration - diagnosis</topic><topic>Retinal Degeneration - drug therapy</topic><topic>Retinal Degeneration - etiology</topic><topic>Retinopathies</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><topic>Visual Acuity</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>To, King W</creatorcontrib><creatorcontrib>Thirkill, Charles E</creatorcontrib><creatorcontrib>Jakobiec, Frederick A</creatorcontrib><creatorcontrib>Lessell, Simmons</creatorcontrib><creatorcontrib>Berson, Eliot L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>To, King W</au><au>Thirkill, Charles E</au><au>Jakobiec, Frederick A</au><au>Lessell, Simmons</au><au>Berson, Eliot L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphoma-associated retinopathy</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>109</volume><issue>11</issue><spage>2149</spage><epage>2153</epage><pages>2149-2153</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To describe the clinical, electrophysiologic, and serologic findings in a patient with retinal degeneration associated with Hodgkin’s lymphoma.
Case report with ancillary immunohistochemical studies.
A 24-year-old woman experienced night blindness and fundus abnormalities 1 week after initiation of chemotherapy for Hodgkin’s lymphoma. Visual fields and full-field electroretinograms (ERGs) were monitored over a 10-year period. Serum antibodies were studied on Western blot reactions on a solubilized extract of bovine retina. Serum antibodies were also evaluated through indirect immunohistochemistry on rhesus monkey retina.
Visual field and ERG amplitudes, initially abnormal, became reduced further over 10 years. Serum antibodies were identified that reacted to a retinal protein or proteins approximating 65 kd; these antibodies showed immunologic activity against photoreceptors.
A progressive paraneoplastic retinopathy can occur in association with Hodgkin’s lymphoma. The pathogenesis of the retinal degeneration appears to be related to a serum antibody that is reacting to a retinal protein or proteins of approximately 65 kd.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12414431</pmid><doi>10.1016/S0161-6420(02)01261-7</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antineoplastic Agents - therapeutic use Autoantibodies - blood Biological and medical sciences Blotting, Western Electroretinography Eye Proteins - immunology Female Hematologic and hematopoietic diseases Hodgkin Disease - complications Hodgkin Disease - diagnosis Hodgkin Disease - drug therapy Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Night Blindness - etiology Ophthalmology Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - drug therapy Paraneoplastic Syndromes - etiology Prednisone - therapeutic use Retina - immunology Retinal Degeneration - diagnosis Retinal Degeneration - drug therapy Retinal Degeneration - etiology Retinopathies Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Visual Acuity Visual Fields |
| title | Lymphoma-associated retinopathy |
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