Use of rodents as models for the study of “normal aging”: Conceptual and practical issues
Certain guidelines may exist for selecting and using rodent models for aging research. These are based, however, on only operational criteria because we presently lack good biomarkers for (or even a suitable definition of) normal aging. Longevity and disease characteristics of the experimental popul...
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| Veröffentlicht in: | Neurobiology of aging 1991-11, Vol.12 (6), p.639-643 |
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| container_title | Neurobiology of aging |
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| creator | Masoro, Edward J. |
| description | Certain guidelines may exist for selecting and using rodent models for aging research. These are based, however, on only operational criteria because we presently lack good biomarkers for (or even a suitable definition of) normal aging. Longevity and disease characteristics of the experimental population are the most important of the operational criteria for choosing a particular rodent model. These factors, in turn, are influenced by genetics and by environmental factors, including diet, housing, and physical activity. |
| doi_str_mv | 10.1016/0197-4580(91)90114-Y |
| format | Article |
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| ispartof | Neurobiology of aging, 1991-11, Vol.12 (6), p.639-643 |
| issn | 0197-4580 1558-1497 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged mice Aged rats Aging - physiology Aging, animal models Animals Biological and medical sciences Development. Metamorphosis. Moult. Ageing Dietary restriction Fundamental and applied biological sciences. Psychology Humans Mice Models, Biological Rats Rodentia - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Use of rodents as models for the study of “normal aging”: Conceptual and practical issues |
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