Predictors of response to monoamine oxidase inhibitors: do they exist?
Multiple regression analysis was conducted on potential response predictors in a double-blind study of monoamine oxidase inhibitors (MAOI) and placebo treatment in 130 depressed outpatients. Positive main effects were found for sex (female), lack of prior hospitalization, presence of precipitating e...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 1991-01, Vol.241 (3), p.181-186 |
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| container_title | European archives of psychiatry and clinical neuroscience |
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| creator | Davidson, J R Giller, E L Zisook, S Helms, M J |
| description | Multiple regression analysis was conducted on potential response predictors in a double-blind study of monoamine oxidase inhibitors (MAOI) and placebo treatment in 130 depressed outpatients. Positive main effects were found for sex (female), lack of prior hospitalization, presence of precipitating events. A negative main effect was found for concurrent physical illness. Treatment x predictor effects were found for distinct quality and non-reactivity. Non-reactivity was associated with positive outcome in the active drug group, but with negative outcome in the placebo group [corrected]. Distinct quality demonstrated a more complex effect, its presence being associated with decreased improvement in the treatment group and greater improvement in the control group. No atypical depressive symptoms predicted MAOI response, and we were unable to characterize a specifically responsive MAOI syndrome. |
| doi_str_mv | 10.1007/BF02219719 |
| format | Article |
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| ispartof | European archives of psychiatry and clinical neuroscience, 1991-01, Vol.241 (3), p.181-186 |
| issn | 0940-1334 1433-8491 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Depressive Disorder - drug therapy Depressive Disorder - psychology Dose-Response Relationship, Drug Female Humans Isocarboxazid - therapeutic use Male Models, Statistical Monoamine Oxidase Inhibitors - therapeutic use Psychiatric Status Rating Scales - statistics & numerical data Psychometrics |
| title | Predictors of response to monoamine oxidase inhibitors: do they exist? |
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