Mycoplasma gallisepticum: influence of cell invasiveness on the outcome of experimental infection in chickens
Abstract Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 2002-11, Vol.34 (3), p.181-186 |
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| container_title | FEMS immunology and medical microbiology |
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| creator | Much, Peter Winner, Florian Stipkovits, László Rosengarten, Renate Citti, Christine |
| description | Abstract
Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma passages were compared in an in vivo setting. After aerosol inoculation of chickens, M. gallisepticum was re-isolated from the inner organs of birds infected with Rlow, whereas no mycoplasma was recovered from the inner organs of birds infected with Rhigh. These results indicate that the two mycoplasma populations derived from strain R differ in their capacity to cross the mucosal barrier and suggest that cell invasion may play a major role in the observed systemic spreading of M. gallisepticum in its chicken host. |
| doi_str_mv | 10.1111/j.1574-695X.2002.tb00622.x |
| format | Article |
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Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma passages were compared in an in vivo setting. After aerosol inoculation of chickens, M. gallisepticum was re-isolated from the inner organs of birds infected with Rlow, whereas no mycoplasma was recovered from the inner organs of birds infected with Rhigh. These results indicate that the two mycoplasma populations derived from strain R differ in their capacity to cross the mucosal barrier and suggest that cell invasion may play a major role in the observed systemic spreading of M. gallisepticum in its chicken host.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1111/j.1574-695X.2002.tb00622.x</identifier><identifier>PMID: 12423769</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Bacteriology ; Biological and medical sciences ; Birds ; Cell invasion ; Cell Movement ; Chickens ; Chickens - anatomy & histology ; Chickens - microbiology ; Experimental infection ; Fundamental and applied biological sciences. Psychology ; Host colonization ; Inoculation ; Invasiveness ; Microbiology ; Mucosa ; Mycoplasma ; Mycoplasma - growth & development ; Mycoplasma - isolation & purification ; Mycoplasma - pathogenicity ; Mycoplasma gallisepticum ; Mycoplasma Infections - microbiology ; Mycoplasma Infections - pathology ; Mycoplasma Infections - veterinary ; Organs ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Phagocytes ; Poultry Diseases - microbiology ; Poultry Diseases - pathology ; Respiratory disease ; Respiratory System - growth & development ; Respiratory System - microbiology ; Systemic infection ; Virulence</subject><ispartof>FEMS immunology and medical microbiology, 2002-11, Vol.34 (3), p.181-186</ispartof><rights>2002 Federation of European Microbiological Societies. 2002</rights><rights>2003 INIST-CNRS</rights><rights>2002 Federation of European Microbiological Societies.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5461-7a82e9e516fb949e90c1a6ece9a0f416af8ddf75e3d1db2774062cb61721b0263</citedby><cites>FETCH-LOGICAL-c5461-7a82e9e516fb949e90c1a6ece9a0f416af8ddf75e3d1db2774062cb61721b0263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-695X.2002.tb00622.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-695X.2002.tb00622.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14463649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12423769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Much, Peter</creatorcontrib><creatorcontrib>Winner, Florian</creatorcontrib><creatorcontrib>Stipkovits, László</creatorcontrib><creatorcontrib>Rosengarten, Renate</creatorcontrib><creatorcontrib>Citti, Christine</creatorcontrib><title>Mycoplasma gallisepticum: influence of cell invasiveness on the outcome of experimental infection in chickens</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>Abstract
Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma passages were compared in an in vivo setting. After aerosol inoculation of chickens, M. gallisepticum was re-isolated from the inner organs of birds infected with Rlow, whereas no mycoplasma was recovered from the inner organs of birds infected with Rhigh. These results indicate that the two mycoplasma populations derived from strain R differ in their capacity to cross the mucosal barrier and suggest that cell invasion may play a major role in the observed systemic spreading of M. gallisepticum in its chicken host.</description><subject>Animals</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Birds</subject><subject>Cell invasion</subject><subject>Cell Movement</subject><subject>Chickens</subject><subject>Chickens - anatomy & histology</subject><subject>Chickens - microbiology</subject><subject>Experimental infection</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Host colonization</subject><subject>Inoculation</subject><subject>Invasiveness</subject><subject>Microbiology</subject><subject>Mucosa</subject><subject>Mycoplasma</subject><subject>Mycoplasma - growth & development</subject><subject>Mycoplasma - isolation & purification</subject><subject>Mycoplasma - pathogenicity</subject><subject>Mycoplasma gallisepticum</subject><subject>Mycoplasma Infections - microbiology</subject><subject>Mycoplasma Infections - pathology</subject><subject>Mycoplasma Infections - veterinary</subject><subject>Organs</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Phagocytes</subject><subject>Poultry Diseases - microbiology</subject><subject>Poultry Diseases - pathology</subject><subject>Respiratory disease</subject><subject>Respiratory System - growth & development</subject><subject>Respiratory System - microbiology</subject><subject>Systemic infection</subject><subject>Virulence</subject><issn>0928-8244</issn><issn>1574-695X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVGL1DAUhYMo7rj6F6Qo-taam6ZJsw-CLK4u7OKLgm8hzdy4Gdu0Nu068-9NneKCKGJeArnfOcnJIeQZ0ALSerUroJI8F6r6XDBKWTE1lArGiv09svk1uk82VLE6rxnnJ-RRjDtKKVeUPiQnwDgrpVAb0l0fbD-0JnYm-2La1kccJm_n7izzwbUzBotZ7zKLbZtObk30txgwxqwP2XSTZvNk--4ng_sBR99hmMzCOrSTT5QPmb3x9iuG-Jg8cKaN-GTdT8mni7cfz9_nVx_eXZ6_ucptxQXk0tQMFVYgXKO4QkUtGIEWlaGOgzCu3m6drLDcwrZhUvIU3zYCJIOGMlGekpdH32Hsv80YJ935uEQwAfs5aslEVctK_hOEWkDJYHF8_hu46-cxpBCalQBU0JKqRJ0dKTv2MY7o9JA-xIwHDVQv3emdXgrSS0F66U6v3el9Ej9dr5ibDrd30rWsBLxYAROtad1ogvXxjuNclIIv3Osj9923ePiPJ-iLy2uoIRlUR4N-Hv4iz_-U4AeDIMeb</recordid><startdate>20021115</startdate><enddate>20021115</enddate><creator>Much, Peter</creator><creator>Winner, Florian</creator><creator>Stipkovits, László</creator><creator>Rosengarten, Renate</creator><creator>Citti, Christine</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7QL</scope><scope>7X8</scope></search><sort><creationdate>20021115</creationdate><title>Mycoplasma gallisepticum: influence of cell invasiveness on the outcome of experimental infection in chickens</title><author>Much, Peter ; Winner, Florian ; Stipkovits, László ; Rosengarten, Renate ; Citti, Christine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5461-7a82e9e516fb949e90c1a6ece9a0f416af8ddf75e3d1db2774062cb61721b0263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Birds</topic><topic>Cell invasion</topic><topic>Cell Movement</topic><topic>Chickens</topic><topic>Chickens - anatomy & histology</topic><topic>Chickens - microbiology</topic><topic>Experimental infection</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Host colonization</topic><topic>Inoculation</topic><topic>Invasiveness</topic><topic>Microbiology</topic><topic>Mucosa</topic><topic>Mycoplasma</topic><topic>Mycoplasma - growth & development</topic><topic>Mycoplasma - isolation & purification</topic><topic>Mycoplasma - pathogenicity</topic><topic>Mycoplasma gallisepticum</topic><topic>Mycoplasma Infections - microbiology</topic><topic>Mycoplasma Infections - pathology</topic><topic>Mycoplasma Infections - veterinary</topic><topic>Organs</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Phagocytes</topic><topic>Poultry Diseases - microbiology</topic><topic>Poultry Diseases - pathology</topic><topic>Respiratory disease</topic><topic>Respiratory System - growth & development</topic><topic>Respiratory System - microbiology</topic><topic>Systemic infection</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Much, Peter</creatorcontrib><creatorcontrib>Winner, Florian</creatorcontrib><creatorcontrib>Stipkovits, László</creatorcontrib><creatorcontrib>Rosengarten, Renate</creatorcontrib><creatorcontrib>Citti, Christine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Much, Peter</au><au>Winner, Florian</au><au>Stipkovits, László</au><au>Rosengarten, Renate</au><au>Citti, Christine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycoplasma gallisepticum: influence of cell invasiveness on the outcome of experimental infection in chickens</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>2002-11-15</date><risdate>2002</risdate><volume>34</volume><issue>3</issue><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><eissn>2049-632X</eissn><abstract>Abstract
Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma passages were compared in an in vivo setting. After aerosol inoculation of chickens, M. gallisepticum was re-isolated from the inner organs of birds infected with Rlow, whereas no mycoplasma was recovered from the inner organs of birds infected with Rhigh. These results indicate that the two mycoplasma populations derived from strain R differ in their capacity to cross the mucosal barrier and suggest that cell invasion may play a major role in the observed systemic spreading of M. gallisepticum in its chicken host.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12423769</pmid><doi>10.1111/j.1574-695X.2002.tb00622.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0928-8244 |
| ispartof | FEMS immunology and medical microbiology, 2002-11, Vol.34 (3), p.181-186 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Bacteriology Biological and medical sciences Birds Cell invasion Cell Movement Chickens Chickens - anatomy & histology Chickens - microbiology Experimental infection Fundamental and applied biological sciences. Psychology Host colonization Inoculation Invasiveness Microbiology Mucosa Mycoplasma Mycoplasma - growth & development Mycoplasma - isolation & purification Mycoplasma - pathogenicity Mycoplasma gallisepticum Mycoplasma Infections - microbiology Mycoplasma Infections - pathology Mycoplasma Infections - veterinary Organs Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phagocytes Poultry Diseases - microbiology Poultry Diseases - pathology Respiratory disease Respiratory System - growth & development Respiratory System - microbiology Systemic infection Virulence |
| title | Mycoplasma gallisepticum: influence of cell invasiveness on the outcome of experimental infection in chickens |
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