Taraxinic Acid, a Hydrolysate of Sesquiterpene Lactone Glycoside from the Taraxacum coreanum NAKAI, Induces the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells

The present work was performed to elucidate the active moiety of a sesquiterpene lactone, taraxinic acid-1′-O-β-D-glucopyranoside (1) from Taraxacum coreanum NAKAI on the cytotoxicity of various cancer cells. Based on enzymatic hydrolysis and MTT assay, the active moiety should be attributed to the...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2002, Vol.25(11), pp.1446-1450
Hauptverfasser:	Choi, Jung-Hye, Shin, Kyung-Min, Kim, Na-Young, Hong, Jung-Pyo, Lee, Yong Sup, Kim, Hyoung Ja, Park, Hee-Juhn, Lee, Kyung-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences c-myc Cell Differentiation - drug effects Cell Differentiation - physiology differentiation General pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology HL-60 cell HL-60 Cells - cytology HL-60 Cells - drug effects Humans Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Medical sciences Mice p21CIP1 p27KIP1 Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Structures - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Taraxacum - chemistry taraxinic acid Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects
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