Increased Monocyte Adhesion to Aortic Endothelium in Rats With Hyperhomocysteinemia: Role of Chemokine and Adhesion Molecules

OBJECTIVE—The stimulatory effect of homocysteine (Hcy) on monocyte chemoattractant protein (MCP)-1 expression in vitro has been suggested to play an important role in Hcy-mediated atherosclerosis. We investigated whether such a stimulatory effect occurs in vivo, leading to monocyte adhesion to the e...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2002-11, Vol.22 (11), p.1777-1783
Hauptverfasser:	Wang, Guoping, Woo, Connie W.H, Sung, Fion L, Siow, Yaw L, O, Karmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacid disorders Animals Aorta, Thoracic - chemistry Aorta, Thoracic - metabolism Aorta, Thoracic - physiopathology Arteriosclerosis - blood Arteriosclerosis - pathology Biological and medical sciences Cell Adhesion Molecules - physiology Chemokine CCL2 - biosynthesis Chemokine CCL2 - physiology Chemokines - physiology Diet - adverse effects Disease Models, Animal E-Selectin - biosynthesis E-Selectin - physiology Endothelium, Vascular - chemistry Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Errors of metabolism Homocysteine - blood Hyperhomocysteinemia - blood Hyperhomocysteinemia - physiopathology In Vitro Techniques Macrophages - chemistry Macrophages - metabolism Macrophages - pathology Male Medical sciences Metabolic diseases Monocytes - chemistry Monocytes - metabolism Monocytes - pathology Rats Rats, Sprague-Dawley Tissue Adhesions - metabolism Tissue Adhesions - pathology Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - physiology
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