Hypoxanthine phosphoribosyl transferase deficiency, haematopoiesis and fertility in the mouse

We have looked for effects of deficiency in hypoxanthine phosphoribosyl transferase (HPRT) in the mouse comparable to non-behavioural consequences of HPRT-deficiency in humans. HPRT-deficient humans show abnormalities in haematopoiesis and, in heterozygotes, there is strong selection in haematopoiet...

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Veröffentlicht in:	Development (Cambridge) 1991-06, Vol.112 (2), p.489-498
Hauptverfasser:	ANSELL, J. D, SAMUEL, K, WHITTINGHAM, D. G, PATEK, C. E, HARDY, K, HANDYSIDE, A. H, JONES, K. W, MUGGLETON-HARRIS, A. L, TAYLOR, A. H, HOOPER, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - enzymology Cell differentiation, maturation, development, hematopoiesis Cell physiology Chimera - physiology Disease Models, Animal DNA Probes Female Fertility - physiology Fundamental and applied biological sciences. Psychology Glucose-6-Phosphate Isomerase - analysis Hematopoiesis - physiology Hypoxanthine Phosphoribosyltransferase - deficiency Isoenzymes Male Mice Molecular and cellular biology Nucleic Acid Hybridization Phosphoglycerate Kinase - deficiency Sex Chromosome Aberrations
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