Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis

Familial adenomatous polyposis and hereditary non-polyposis colorectal cancer are dominantly inherited conditions with 100% and 80% life-time risk of developing colorectal cancer, respectively. The genetic mutations responsible for these two conditions lie in the adenomatous polyposis coli (APC) and...

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Veröffentlicht in:	British medical bulletin 2002-01, Vol.64 (1), p.27-43
Hauptverfasser:	Fearnhead, Nicola S, Wilding, Jennifer L, Bodmer, Walter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - pathology Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression Genes, APC Genetic Diseases, Inborn - etiology Genetic Diseases, Inborn - pathology Genetic Predisposition to Disease Germ-Line Mutation Humans Mutation Risk Factors
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