Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes
To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanol...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 1991/12/15, Vol.53(6), pp.1001-1007 |
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| creator | Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture) Tamura, S Ono, K Watari, T Goitsuka, R Yamanobe, A Hiraga, A Kubo, K Takagi, S Hasegawa, A Suzuki, N |
| description | To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanolamine (PE) were increased at 24 hours after the exercise. The malondialdehydes (MDAs) were also increased as the protein-bound MDAs following exercise. In the erythrocytes, the peroxidized PE were significantly decreased at 24 hours after the exercise. The protein-bound MDAs were significantly increased at 5 min after the exercise and returned to the base values at 24 hours after the exercise. These findings indicate that the PE is more susceptible to in vivo oxidative effects than the other phospholipid classes, and the accumulation of the protein-bound MDAs is considered to play some cytotoxic roles in the equine skeletal muscle and erythrocytes following exercise. |
| doi_str_mv | 10.1292/jvms.53.1001 |
| format | Article |
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(Tokyo Univ. (Japan). Faculty of Agriculture) ; Tamura, S ; Ono, K ; Watari, T ; Goitsuka, R ; Yamanobe, A ; Hiraga, A ; Kubo, K ; Takagi, S ; Hasegawa, A ; Suzuki, N</creator><creatorcontrib>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture) ; Tamura, S ; Ono, K ; Watari, T ; Goitsuka, R ; Yamanobe, A ; Hiraga, A ; Kubo, K ; Takagi, S ; Hasegawa, A ; Suzuki, N</creatorcontrib><description>To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanolamine (PE) were increased at 24 hours after the exercise. The malondialdehydes (MDAs) were also increased as the protein-bound MDAs following exercise. In the erythrocytes, the peroxidized PE were significantly decreased at 24 hours after the exercise. The protein-bound MDAs were significantly increased at 5 min after the exercise and returned to the base values at 24 hours after the exercise. These findings indicate that the PE is more susceptible to in vivo oxidative effects than the other phospholipid classes, and the accumulation of the protein-bound MDAs is considered to play some cytotoxic roles in the equine skeletal muscle and erythrocytes following exercise.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.53.1001</identifier><identifier>PMID: 1790208</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ACTIVIDAD FISICA ; ACTIVITE PHYSIQUE ; Animals ; BONES ; CABALLOS ; CHEVAL ; Creatine Kinase - blood ; DEGRADACION ; DEGRADATION ; ERITROCITOS ; ERYTHROCYTE ; ERYTHROCYTES ; Erythrocytes - metabolism ; exercise ; Female ; Hematocrit - veterinary ; horse ; HORSES ; Horses - blood ; Horses - physiology ; HUESOS ; Lactates - blood ; Male ; malondialdehyde ; Malondialdehyde - blood ; Malondialdehyde - metabolism ; METABOLISME DES PHOSPHOLIPIDES ; METABOLISMO DE FOSFOLIPIDOS ; MUSCLE ; MUSCLES ; Muscles - metabolism ; MUSCULOS ; Oxidation-Reduction ; Phosphatidylcholines - blood ; Phosphatidylcholines - metabolism ; Phosphatidylethanolamines - blood ; Phosphatidylethanolamines - metabolism ; Phosphatidylinositols - blood ; Phosphatidylserines - blood ; PHOSPHOLIPID METABOLISM ; phospholipid peroxidation ; Phospholipids - blood ; Phospholipids - metabolism ; PHYSICAL ACTIVITY ; Physical Exertion - physiology ; Space life sciences</subject><ispartof>Journal of Veterinary Medical Science, 1991/12/15, Vol.53(6), pp.1001-1007</ispartof><rights>The Japanese Society of Veterinary Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c13b03be605a4de384dcad6d9a9ed1eabb7765a7a016fc2fa9504fea942084763</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1790208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Tamura, S</creatorcontrib><creatorcontrib>Ono, K</creatorcontrib><creatorcontrib>Watari, T</creatorcontrib><creatorcontrib>Goitsuka, R</creatorcontrib><creatorcontrib>Yamanobe, A</creatorcontrib><creatorcontrib>Hiraga, A</creatorcontrib><creatorcontrib>Kubo, K</creatorcontrib><creatorcontrib>Takagi, S</creatorcontrib><creatorcontrib>Hasegawa, A</creatorcontrib><creatorcontrib>Suzuki, N</creatorcontrib><title>Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanolamine (PE) were increased at 24 hours after the exercise. The malondialdehydes (MDAs) were also increased as the protein-bound MDAs following exercise. In the erythrocytes, the peroxidized PE were significantly decreased at 24 hours after the exercise. The protein-bound MDAs were significantly increased at 5 min after the exercise and returned to the base values at 24 hours after the exercise. These findings indicate that the PE is more susceptible to in vivo oxidative effects than the other phospholipid classes, and the accumulation of the protein-bound MDAs is considered to play some cytotoxic roles in the equine skeletal muscle and erythrocytes following exercise.</description><subject>ACTIVIDAD FISICA</subject><subject>ACTIVITE PHYSIQUE</subject><subject>Animals</subject><subject>BONES</subject><subject>CABALLOS</subject><subject>CHEVAL</subject><subject>Creatine Kinase - blood</subject><subject>DEGRADACION</subject><subject>DEGRADATION</subject><subject>ERITROCITOS</subject><subject>ERYTHROCYTE</subject><subject>ERYTHROCYTES</subject><subject>Erythrocytes - metabolism</subject><subject>exercise</subject><subject>Female</subject><subject>Hematocrit - veterinary</subject><subject>horse</subject><subject>HORSES</subject><subject>Horses - blood</subject><subject>Horses - physiology</subject><subject>HUESOS</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Malondialdehyde - metabolism</subject><subject>METABOLISME DES PHOSPHOLIPIDES</subject><subject>METABOLISMO DE FOSFOLIPIDOS</subject><subject>MUSCLE</subject><subject>MUSCLES</subject><subject>Muscles - metabolism</subject><subject>MUSCULOS</subject><subject>Oxidation-Reduction</subject><subject>Phosphatidylcholines - blood</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Phosphatidylethanolamines - blood</subject><subject>Phosphatidylethanolamines - metabolism</subject><subject>Phosphatidylinositols - blood</subject><subject>Phosphatidylserines - blood</subject><subject>PHOSPHOLIPID METABOLISM</subject><subject>phospholipid peroxidation</subject><subject>Phospholipids - blood</subject><subject>Phospholipids - metabolism</subject><subject>PHYSICAL ACTIVITY</subject><subject>Physical Exertion - physiology</subject><subject>Space life sciences</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE2LFDEQhoMo6-zqzZMg5ORpe0w6X5ujLOMXC3pQ8Baqk-qZjP0xm6TF-fd228t6qKrD-_JQPIS84mzLa1u_O_7u81aJLWeMPyEbLqSpjBT2Kdkwy3VlasWek8ucj4zVXGp7QS64saxmNxvyc_cHk48ZqziEyWOgp8OY5-niKQYacJ8gQInjQONAywEp3k9xQJp_YYcFOtpP2XdIYQgU07kc0ujPBfML8qyFLuPLh3tFfnzYfb_9VN19_fj59v1d5SVTpfJcNEw0qJkCGVDcyOAh6GDBYuAITWOMVmCAcd36ugWrmGwRrJzfl0aLK_J25Z7SeD9hLq6P2WPXwYDjlJ2ptVK2FnPxei36NOacsHWnFHtIZ8eZW0S6RaRTwi0i5_qbB-7U9Bj-l1dzc75b82MusMfHHFKJs49_MG4tX4B6XQv3MfcHSA6HmfN65bQwOtinmN2Xb1YyJpUSfwH_upGn</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture)</creator><creator>Tamura, S</creator><creator>Ono, K</creator><creator>Watari, T</creator><creator>Goitsuka, R</creator><creator>Yamanobe, A</creator><creator>Hiraga, A</creator><creator>Kubo, K</creator><creator>Takagi, S</creator><creator>Hasegawa, A</creator><creator>Suzuki, N</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes</title><author>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture) ; Tamura, S ; Ono, K ; Watari, T ; Goitsuka, R ; Yamanobe, A ; Hiraga, A ; Kubo, K ; Takagi, S ; Hasegawa, A ; Suzuki, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c13b03be605a4de384dcad6d9a9ed1eabb7765a7a016fc2fa9504fea942084763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>ACTIVIDAD FISICA</topic><topic>ACTIVITE PHYSIQUE</topic><topic>Animals</topic><topic>BONES</topic><topic>CABALLOS</topic><topic>CHEVAL</topic><topic>Creatine Kinase - blood</topic><topic>DEGRADACION</topic><topic>DEGRADATION</topic><topic>ERITROCITOS</topic><topic>ERYTHROCYTE</topic><topic>ERYTHROCYTES</topic><topic>Erythrocytes - metabolism</topic><topic>exercise</topic><topic>Female</topic><topic>Hematocrit - veterinary</topic><topic>horse</topic><topic>HORSES</topic><topic>Horses - blood</topic><topic>Horses - physiology</topic><topic>HUESOS</topic><topic>Lactates - blood</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Malondialdehyde - metabolism</topic><topic>METABOLISME DES PHOSPHOLIPIDES</topic><topic>METABOLISMO DE FOSFOLIPIDOS</topic><topic>MUSCLE</topic><topic>MUSCLES</topic><topic>Muscles - metabolism</topic><topic>MUSCULOS</topic><topic>Oxidation-Reduction</topic><topic>Phosphatidylcholines - blood</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Phosphatidylethanolamines - blood</topic><topic>Phosphatidylethanolamines - metabolism</topic><topic>Phosphatidylinositols - blood</topic><topic>Phosphatidylserines - blood</topic><topic>PHOSPHOLIPID METABOLISM</topic><topic>phospholipid peroxidation</topic><topic>Phospholipids - blood</topic><topic>Phospholipids - metabolism</topic><topic>PHYSICAL ACTIVITY</topic><topic>Physical Exertion - physiology</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Tamura, S</creatorcontrib><creatorcontrib>Ono, K</creatorcontrib><creatorcontrib>Watari, T</creatorcontrib><creatorcontrib>Goitsuka, R</creatorcontrib><creatorcontrib>Yamanobe, A</creatorcontrib><creatorcontrib>Hiraga, A</creatorcontrib><creatorcontrib>Kubo, K</creatorcontrib><creatorcontrib>Takagi, S</creatorcontrib><creatorcontrib>Hasegawa, A</creatorcontrib><creatorcontrib>Suzuki, N</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture)</au><au>Tamura, S</au><au>Ono, K</au><au>Watari, T</au><au>Goitsuka, R</au><au>Yamanobe, A</au><au>Hiraga, A</au><au>Kubo, K</au><au>Takagi, S</au><au>Hasegawa, A</au><au>Suzuki, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>53</volume><issue>6</issue><spage>1001</spage><epage>1007</epage><pages>1001-1007</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal muscle and erythrocytes following the high-speed treadmill exercise were studied. In the skeletal muscle, the peroxidized phosphatidylethanolamine (PE) were increased at 24 hours after the exercise. The malondialdehydes (MDAs) were also increased as the protein-bound MDAs following exercise. In the erythrocytes, the peroxidized PE were significantly decreased at 24 hours after the exercise. The protein-bound MDAs were significantly increased at 5 min after the exercise and returned to the base values at 24 hours after the exercise. These findings indicate that the PE is more susceptible to in vivo oxidative effects than the other phospholipid classes, and the accumulation of the protein-bound MDAs is considered to play some cytotoxic roles in the equine skeletal muscle and erythrocytes following exercise.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>1790208</pmid><doi>10.1292/jvms.53.1001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0916-7250 |
| ispartof | Journal of Veterinary Medical Science, 1991/12/15, Vol.53(6), pp.1001-1007 |
| issn | 0916-7250 1347-7439 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | ACTIVIDAD FISICA ACTIVITE PHYSIQUE Animals BONES CABALLOS CHEVAL Creatine Kinase - blood DEGRADACION DEGRADATION ERITROCITOS ERYTHROCYTE ERYTHROCYTES Erythrocytes - metabolism exercise Female Hematocrit - veterinary horse HORSES Horses - blood Horses - physiology HUESOS Lactates - blood Male malondialdehyde Malondialdehyde - blood Malondialdehyde - metabolism METABOLISME DES PHOSPHOLIPIDES METABOLISMO DE FOSFOLIPIDOS MUSCLE MUSCLES Muscles - metabolism MUSCULOS Oxidation-Reduction Phosphatidylcholines - blood Phosphatidylcholines - metabolism Phosphatidylethanolamines - blood Phosphatidylethanolamines - metabolism Phosphatidylinositols - blood Phosphatidylserines - blood PHOSPHOLIPID METABOLISM phospholipid peroxidation Phospholipids - blood Phospholipids - metabolism PHYSICAL ACTIVITY Physical Exertion - physiology Space life sciences |
| title | Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes |
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