Interaction of Sildenafil With cAMP-Mediated Vasodilation In Vivo

ABSTRACT—Sildenafil inhibits cGMP breakdown by phosphodiesterase 5. In vitro, increased cGMP levels inhibit cAMP breakdown by phosphodiesterase 3. It is uncertain, however, whether sildenafil increases biological effects of interventions increasing cAMP levels in vivo. The objective of the present s...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-11, Vol.40 (5), p.763-767
Hauptverfasser:	Schalcher, Christoph, Schad, Karin, Brunner-La Rocca, Hans Peter, Schindler, Ruth, Oechslin, Erwin, Scharf, Christoph, Suetsch, Gabor, Bertel, Osmund, Kiowski, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Adult Blood Pressure - drug effects Brachial Artery - drug effects Brachial Artery - physiology Cyclic AMP - metabolism Cyclic GMP - metabolism Forearm - blood supply Heart Rate - drug effects Hemodynamics - drug effects Humans Isoproterenol - pharmacology Male Milrinone - pharmacology Nitroglycerin - pharmacology Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Regional Blood Flow - drug effects Sildenafil Citrate Sulfones Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
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