Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands

The selectivity of two new radioligands, [(125)I]YVP ([(125)I]YVPNLPQRF-NH(2)) and [(125)I]EYF ([(125)I]EYWSLAAPQRF-NH(2)), for neuropeptide FF (NPFF) receptor subtypes was determined using HEK293 cells expressing hNPFF(1) and CHO cells expressing hNPFF(2) receptors. Saturation binding and displacem...

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Veröffentlicht in:	Neuroscience 2002-01, Vol.115 (2), p.349-361
Hauptverfasser:	Gouardères, C, Quelven, I, Mollereau, C, Mazarguil, H, Rice, S Q J, Zajac, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Brain Chemistry CHO Cells Cricetinae Humans Iodine Radioisotopes Kidney - cytology Male Oligopeptides - metabolism Oligopeptides - pharmacology Protein Binding Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Neuropeptide - analysis Receptors, Neuropeptide - metabolism Spinal Cord - chemistry
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