Phagocytosis by macrophages in zinc-deficient rats
Phagocytosis by polymorphonuclear cells has been found to be significantly reduced in zinc-deficient patients and this finding was confirmed in animal experiments. In order to find out whether phagocytosis by macrophages is similarly altered, experiments were conducted in three groups of 18 rats. Co...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1991, Vol.18 (7), p.765-768 |
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| container_title | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology |
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| creator | Ercan, Meral T. Bor, Naci M. |
| description | Phagocytosis by polymorphonuclear cells has been found to be significantly reduced in zinc-deficient patients and this finding was confirmed in animal experiments. In order to find out whether phagocytosis by macrophages is similarly altered, experiments were conducted in three groups of 18 rats. Control, zinc-deficient and pair-fed rats were given
99mTc nanocolloid intravenously. In ten other experiments (5 experimental and 5 control rats)
99mTc-sulfur colloid was injected intravenously. The biodistribution was determined by a well-type gamma counter and the results were evaluated statistically. The greatest amount of radioactivity was taken up by the liver, followed by the spleen, lung and kidney. In both series of experiments however the zinc-deficient animals appeared to take up a greater amount of the radiotracer (
P < 0.05). |
| doi_str_mv | 10.1016/0883-2897(91)90015-D |
| format | Article |
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99mTc nanocolloid intravenously. In ten other experiments (5 experimental and 5 control rats)
99mTc-sulfur colloid was injected intravenously. The biodistribution was determined by a well-type gamma counter and the results were evaluated statistically. The greatest amount of radioactivity was taken up by the liver, followed by the spleen, lung and kidney. In both series of experiments however the zinc-deficient animals appeared to take up a greater amount of the radiotracer (
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99mTc nanocolloid intravenously. In ten other experiments (5 experimental and 5 control rats)
99mTc-sulfur colloid was injected intravenously. The biodistribution was determined by a well-type gamma counter and the results were evaluated statistically. The greatest amount of radioactivity was taken up by the liver, followed by the spleen, lung and kidney. In both series of experiments however the zinc-deficient animals appeared to take up a greater amount of the radiotracer (
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99mTc nanocolloid intravenously. In ten other experiments (5 experimental and 5 control rats)
99mTc-sulfur colloid was injected intravenously. The biodistribution was determined by a well-type gamma counter and the results were evaluated statistically. The greatest amount of radioactivity was taken up by the liver, followed by the spleen, lung and kidney. In both series of experiments however the zinc-deficient animals appeared to take up a greater amount of the radiotracer (
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| identifier | ISSN: 0883-2897 |
| ispartof | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1991, Vol.18 (7), p.765-768 |
| issn | 0883-2897 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Kidney - metabolism Liver - metabolism Lung - metabolism Macrophages - immunology Medical sciences Microspheres Phagocytosis Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Spleen - metabolism Technetium Tc 99m Sulfur Colloid Tissue Distribution Zinc - deficiency |
| title | Phagocytosis by macrophages in zinc-deficient rats |
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