Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander

Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel™, were conducted in mice after either an i.v. dose (40 μg/kg) or a p.o. dose (80 μg/kg). Oleandrin was rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half‐life was longer (2.3 ± 0.5 h) t...

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Veröffentlicht in:	Journal of experimental therapeutics & oncology 2002-09, Vol.2 (5), p.278-285
Hauptverfasser:	Ni, Dan, Madden, Timothy L., Johansen, Mary, Felix, Edward, Ho, Dah H., Newman, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer drug Antineoplastic Agents, Phytogenic - pharmacokinetics Brain - metabolism Cardenolides - pharmacokinetics Humans Male Mice oleander extract oleandrin pharmacokinetics Tissue Distribution
Online-Zugang:	Volltext
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