Regulation of ovarian function: the role of anti-Mullerian hormone
Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors. In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal func...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2002-11, Vol.124 (5), p.601-609 |
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| creator | Durlinger, AL Visser, JA Themmen, AP |
| description | Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors. In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal function of AMH is to induce regression of the Mullerian ducts during male sex differentiation. However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis. This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness of growing follicles to FSH. |
| doi_str_mv | 10.1530/rep.0.1240601 |
| format | Article |
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In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal function of AMH is to induce regression of the Mullerian ducts during male sex differentiation. However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis. This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness of growing follicles to FSH.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/rep.0.1240601</identifier><identifier>PMID: 12416998</identifier><language>eng</language><publisher>Colchester: Society for Reproduction and Fertility</publisher><subject>Animals ; Anti-Mullerian Hormone ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers, Tumor - blood ; Depression, Chemical ; Female ; Follicle Stimulating Hormone - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Glycoproteins ; Granulosa Cell Tumor - diagnosis ; Granulosa Cells - metabolism ; Growth Inhibitors - pharmacology ; Growth Inhibitors - physiology ; Humans ; Male ; Mammalian female genital system ; Mice ; Mice, Knockout ; Morphology. Physiology ; Mullerian Ducts - embryology ; Ovarian Follicle - drug effects ; Ovarian Follicle - physiology ; Ovarian Neoplasms - diagnosis ; Ovary - physiology ; Rats ; Receptors, Peptide - metabolism ; Receptors, Transforming Growth Factor beta ; Signal Transduction - physiology ; Testicular Hormones - pharmacology ; Testicular Hormones - physiology ; Vertebrates: reproduction</subject><ispartof>Reproduction (Cambridge, England), 2002-11, Vol.124 (5), p.601-609</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4601-405e5d7367a77e88a1a92f17ec7dd6973b5232df9fb8c9ff9c8a01b3d334c43b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14016045$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12416998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durlinger, AL</creatorcontrib><creatorcontrib>Visser, JA</creatorcontrib><creatorcontrib>Themmen, AP</creatorcontrib><title>Regulation of ovarian function: the role of anti-Mullerian hormone</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors. In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal function of AMH is to induce regression of the Mullerian ducts during male sex differentiation. However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis. This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness of growing follicles to FSH.</description><subject>Animals</subject><subject>Anti-Mullerian Hormone</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers, Tumor - blood</subject><subject>Depression, Chemical</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Glycoproteins</subject><subject>Granulosa Cell Tumor - diagnosis</subject><subject>Granulosa Cells - metabolism</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Growth Inhibitors - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mammalian female genital system</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Morphology. Physiology</subject><subject>Mullerian Ducts - embryology</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovarian Follicle - physiology</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovary - physiology</subject><subject>Rats</subject><subject>Receptors, Peptide - metabolism</subject><subject>Receptors, Transforming Growth Factor beta</subject><subject>Signal Transduction - physiology</subject><subject>Testicular Hormones - pharmacology</subject><subject>Testicular Hormones - physiology</subject><subject>Vertebrates: reproduction</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M9LwzAUB_AgitPp0av0orfOpEmTxpsOf8FEED2XNH3ZIl0zk1bxvzezg4GgpzyST957fBE6IXhCcoovPKwmscwY5pjsoAMiGElFIeVurJnAKeEZH6HDEN4wJnkh-D4aRU64lMUBun6Ged-ozro2cSZxH8pb1Samb_X67jLpFpB418D6VbWdTR_7poEftHB-6Vo4QntGNQGON-cYvd7evEzv09nT3cP0apZWLK6WMpxDXgvKhRICikIRJTNDBGhR11wKWuUZzWojTVVoaYzUhcKkojWlTDNa0TE6H_quvHvvIXTl0gYNTaNacH0oRcZzSjiLMB2g9i4ED6ZcebtU_qskuFyHVsbQylgOoUV_umncV0uot3qTUgRnG6CCVo3xqtU2bB3DhGOWR8cGt7Dzxaf1UFbWBW0h5masVn_Op8O3X_r_rb8BfwSWnQ</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Durlinger, AL</creator><creator>Visser, JA</creator><creator>Themmen, AP</creator><general>Society for Reproduction and Fertility</general><general>Portland</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Regulation of ovarian function: the role of anti-Mullerian hormone</title><author>Durlinger, AL ; Visser, JA ; Themmen, AP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4601-405e5d7367a77e88a1a92f17ec7dd6973b5232df9fb8c9ff9c8a01b3d334c43b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anti-Mullerian Hormone</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Depression, Chemical</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Glycoproteins</topic><topic>Granulosa Cell Tumor - diagnosis</topic><topic>Granulosa Cells - metabolism</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Growth Inhibitors - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Mammalian female genital system</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Morphology. Physiology</topic><topic>Mullerian Ducts - embryology</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovarian Follicle - physiology</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovary - physiology</topic><topic>Rats</topic><topic>Receptors, Peptide - metabolism</topic><topic>Receptors, Transforming Growth Factor beta</topic><topic>Signal Transduction - physiology</topic><topic>Testicular Hormones - pharmacology</topic><topic>Testicular Hormones - physiology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durlinger, AL</creatorcontrib><creatorcontrib>Visser, JA</creatorcontrib><creatorcontrib>Themmen, AP</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durlinger, AL</au><au>Visser, JA</au><au>Themmen, AP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of ovarian function: the role of anti-Mullerian hormone</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>124</volume><issue>5</issue><spage>601</spage><epage>609</epage><pages>601-609</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors. In contrast to other members of the family, which exert a broad range of functions in multiple tissues, the principal function of AMH is to induce regression of the Mullerian ducts during male sex differentiation. However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis. This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness of growing follicles to FSH.</abstract><cop>Colchester</cop><pub>Society for Reproduction and Fertility</pub><pmid>12416998</pmid><doi>10.1530/rep.0.1240601</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Mullerian Hormone Biological and medical sciences Biomarkers - blood Biomarkers, Tumor - blood Depression, Chemical Female Follicle Stimulating Hormone - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Glycoproteins Granulosa Cell Tumor - diagnosis Granulosa Cells - metabolism Growth Inhibitors - pharmacology Growth Inhibitors - physiology Humans Male Mammalian female genital system Mice Mice, Knockout Morphology. Physiology Mullerian Ducts - embryology Ovarian Follicle - drug effects Ovarian Follicle - physiology Ovarian Neoplasms - diagnosis Ovary - physiology Rats Receptors, Peptide - metabolism Receptors, Transforming Growth Factor beta Signal Transduction - physiology Testicular Hormones - pharmacology Testicular Hormones - physiology Vertebrates: reproduction |
| title | Regulation of ovarian function: the role of anti-Mullerian hormone |
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