Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)
We present a unique chromosomal abnormality found in a patient with acute myeloblastic leukemia of French–American–British subtype M3. The patient was referred for an evaluation of a chromosomal anomaly exclusively associated with FAB M3 or acute promyelocytic leukemia: a translocation between chrom...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2002-10, Vol.138 (1), p.17-21 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Zhang, Lijun Mulvihill, John J Kern, William F McMinn, Johnny Li, Shibo |
| description | We present a unique chromosomal abnormality found in a patient with acute myeloblastic leukemia of French–American–British subtype M3. The patient was referred for an evaluation of a chromosomal anomaly exclusively associated with FAB M3 or acute promyelocytic leukemia: a translocation between chromosomes 15 and 17, t(15;17)(q22;q21.1). Neither t(15;17) nor rearrangement of
RARα was detected by routine G-banded chromosome as well as fluorescence in situ hybridization analysis using the commercial dual-color
PML/RARα translocation probe and the
RARα probe, a break apart rearrangement dual-color probe. Instead of the typical rearrangement between chromosomes 15 and 17, all cells analyzed had a duplication of the segment of chromosome 15 between bands 15q15 and 15q26. |
| doi_str_mv | 10.1016/S0165-4608(02)00538-1 |
| format | Article |
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RARα was detected by routine G-banded chromosome as well as fluorescence in situ hybridization analysis using the commercial dual-color
PML/RARα translocation probe and the
RARα probe, a break apart rearrangement dual-color probe. Instead of the typical rearrangement between chromosomes 15 and 17, all cells analyzed had a duplication of the segment of chromosome 15 between bands 15q15 and 15q26.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(02)00538-1</identifier><identifier>PMID: 12419579</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Bone Marrow - pathology ; Chromosomes, Human, Pair 15 - genetics ; Chromosomes, Human, Pair 17 ; Gene Duplication ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Translocation, Genetic</subject><ispartof>Cancer genetics and cytogenetics, 2002-10, Vol.138 (1), p.17-21</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-58b646eb09201e0768cd47a29d89c4bad36c9f6dd6bdbd6fcb5f6feb53d1d64c3</citedby><cites>FETCH-LOGICAL-c391t-58b646eb09201e0768cd47a29d89c4bad36c9f6dd6bdbd6fcb5f6feb53d1d64c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165460802005381$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13967867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12419579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Mulvihill, John J</creatorcontrib><creatorcontrib>Kern, William F</creatorcontrib><creatorcontrib>McMinn, Johnny</creatorcontrib><creatorcontrib>Li, Shibo</creatorcontrib><title>Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We present a unique chromosomal abnormality found in a patient with acute myeloblastic leukemia of French–American–British subtype M3. The patient was referred for an evaluation of a chromosomal anomaly exclusively associated with FAB M3 or acute promyelocytic leukemia: a translocation between chromosomes 15 and 17, t(15;17)(q22;q21.1). Neither t(15;17) nor rearrangement of
RARα was detected by routine G-banded chromosome as well as fluorescence in situ hybridization analysis using the commercial dual-color
PML/RARα translocation probe and the
RARα probe, a break apart rearrangement dual-color probe. Instead of the typical rearrangement between chromosomes 15 and 17, all cells analyzed had a duplication of the segment of chromosome 15 between bands 15q15 and 15q26.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Chromosomes, Human, Pair 15 - genetics</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Gene Duplication</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Translocation, Genetic</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwD5AmoPATvxR6weEGr5kipxAM6WM56oBifexg5o_z3e7ooeuczM4ZmZVw8hLzh7wxlXb7_VIhuhWH_O2gvGZNc3_BHZ8F53jRBSPSabf8gJOc35J2NMt0Y9JSe8FdxIbTbEXq_bGMCVkGbK5R11mZZbpDlFpG5Ok4s7GuY6UgdrQbpd0rTDmGBXAtCI6y-cgqPbegHnQv-EcpvWQss5l5dcXzwjT0YXMz4_9jPy4-OH71efm5uvn75cvb9poDO8NLIflFA4MNMyjkyrHrzQrjW-NyAG5zsFZlTeq8EPXo0wyFGNOMjOc68EdGfk9eFuzXe3Yi52ChkwRjdjWrPVrZKtEryC8gDCknJecLTbJUxu2VnO7N6svTdr99osa-29Wbvfe3l8sA4T-oeto8oKvDoCLoOL4-JmCPmB64zSvdKVe3fgsOr4HXCxGao6QB8WhGJ9Cv-J8heZ7ZV8</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Zhang, Lijun</creator><creator>Mulvihill, John J</creator><creator>Kern, William F</creator><creator>McMinn, Johnny</creator><creator>Li, Shibo</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)</title><author>Zhang, Lijun ; Mulvihill, John J ; Kern, William F ; McMinn, Johnny ; Li, Shibo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-58b646eb09201e0768cd47a29d89c4bad36c9f6dd6bdbd6fcb5f6feb53d1d64c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Chromosomes, Human, Pair 15 - genetics</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Gene Duplication</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Translocation, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Mulvihill, John J</creatorcontrib><creatorcontrib>Kern, William F</creatorcontrib><creatorcontrib>McMinn, Johnny</creatorcontrib><creatorcontrib>Li, Shibo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lijun</au><au>Mulvihill, John J</au><au>Kern, William F</au><au>McMinn, Johnny</au><au>Li, Shibo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>138</volume><issue>1</issue><spage>17</spage><epage>21</epage><pages>17-21</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We present a unique chromosomal abnormality found in a patient with acute myeloblastic leukemia of French–American–British subtype M3. The patient was referred for an evaluation of a chromosomal anomaly exclusively associated with FAB M3 or acute promyelocytic leukemia: a translocation between chromosomes 15 and 17, t(15;17)(q22;q21.1). Neither t(15;17) nor rearrangement of
RARα was detected by routine G-banded chromosome as well as fluorescence in situ hybridization analysis using the commercial dual-color
PML/RARα translocation probe and the
RARα probe, a break apart rearrangement dual-color probe. Instead of the typical rearrangement between chromosomes 15 and 17, all cells analyzed had a duplication of the segment of chromosome 15 between bands 15q15 and 15q26.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12419579</pmid><doi>10.1016/S0165-4608(02)00538-1</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Bone Marrow - pathology Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 17 Gene Duplication Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Translocation, Genetic |
| title | Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17) |
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