Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs
Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to th...
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| Veröffentlicht in: | Brain research bulletin 1991-12, Vol.27 (6), p.857-859 |
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| container_title | Brain research bulletin |
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| creator | Quock, Raymond M. Vaughn, Linda K. |
| description | Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4–6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8–10 and 12–15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs. |
| doi_str_mv | 10.1016/0361-9230(91)90223-7 |
| format | Article |
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Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4–6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8–10 and 12–15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(91)90223-7</identifier><identifier>PMID: 1786566</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aging - physiology ; Animals ; Apomorphine ; Apomorphine - pharmacology ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Body temperature ; Body Temperature - drug effects ; Dopamine ; Drug toxicity and drugs side effects treatment ; Female ; Hypertension ; Hypertension - physiopathology ; Hypothermia - chemically induced ; Hypothermia - physiopathology ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Spontaneously hypertensive rat ; Time Factors</subject><ispartof>Brain research bulletin, 1991-12, Vol.27 (6), p.857-859</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-5f026fedb9c0b41be6c2b8d7a833c3105321c30adeed28a318f34087c5cd746e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(91)90223-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5018438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1786566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quock, Raymond M.</creatorcontrib><creatorcontrib>Vaughn, Linda K.</creatorcontrib><title>Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4–6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8–10 and 12–15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Apomorphine</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Body temperature</subject><subject>Body Temperature - drug effects</subject><subject>Dopamine</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Hypertension</subject><subject>Hypertension - physiopathology</subject><subject>Hypothermia - chemically induced</subject><subject>Hypothermia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Spontaneously hypertensive rat</subject><subject>Time Factors</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpSDfb_oMEfCghOTjVhy3Jl0IJSTYQCKRNrkKWxqyKLbmSdyH_PjK7bG_JaWDeZ16GB6FTgq8IJvwHZpyUDWX4oiGXDaaUleITWhApWElFJT6jxQH5gk5S-osx5rLmx-iYCMlrzhfo5d6bCDqBLfQYhhDHtfNQOm83Ju_Wr2OY1hAHp4sxQl5BKixsoQ_jAH4qQjczECfwyQVfOF_8Xj2lr-io032Cb_u5RM-3N3-uV-XD49399a-H0jDOp7LuMOUd2LYxuK1IC9zQVlqhJWOGEVwzSgzD2gJYKjUjsmMVlsLUxoqKA1ui813vGMO_DaRJDS4Z6HvtIWySEpTXpGnYhyDhWFSUkgxWO9DEkFKETo3RDTq-KoLV7F3NUtUsVTV5zt6VyGdn-_5NO4D9f7QTnfPv-1wno_suam9cOmA1JrJiMmM_dxhkaVsHUSXjwGfvLtuflA3u_T_eAO6Vnz8</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Quock, Raymond M.</creator><creator>Vaughn, Linda K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs</title><author>Quock, Raymond M. ; Vaughn, Linda K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-5f026fedb9c0b41be6c2b8d7a833c3105321c30adeed28a318f34087c5cd746e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Apomorphine</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Body temperature</topic><topic>Body Temperature - drug effects</topic><topic>Dopamine</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Hypertension</topic><topic>Hypertension - physiopathology</topic><topic>Hypothermia - chemically induced</topic><topic>Hypothermia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Spontaneously hypertensive rat</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quock, Raymond M.</creatorcontrib><creatorcontrib>Vaughn, Linda K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quock, Raymond M.</au><au>Vaughn, Linda K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>27</volume><issue>6</issue><spage>857</spage><epage>859</epage><pages>857-859</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4–6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8–10 and 12–15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1786566</pmid><doi>10.1016/0361-9230(91)90223-7</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1991-12, Vol.27 (6), p.857-859 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging - physiology Animals Apomorphine Apomorphine - pharmacology Biological and medical sciences Blood pressure Blood Pressure - drug effects Body temperature Body Temperature - drug effects Dopamine Drug toxicity and drugs side effects treatment Female Hypertension Hypertension - physiopathology Hypothermia - chemically induced Hypothermia - physiopathology Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Inbred WKY Spontaneously hypertensive rat Time Factors |
| title | Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs |
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