Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of...
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| Veröffentlicht in: | Journal of ethnopharmacology 2002-11, Vol.83 (1), p.153-159 |
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| creator | Hong, Chae Hee Hur, Sun Kyung Oh, O-Jin Kim, Sun Sook Nam, Kyung Ae Lee, Sang Kook |
| description | The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E
2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as
Aristolochia debilis,
Cinnamomum cassia,
Cinnamomum loureirii,
Curcuma zedoaria,
Eugenia caryophyllata,
Pterocarpus santalius,
Rehmania glutinosa and
Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 μg/ml). In addition, the extracts of
A. debilis,
Caesalpinia sappan,
Curcuma longa,
C. zedoaria,
Daphne genkwa and
Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 μg/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents. |
| doi_str_mv | 10.1016/S0378-8741(02)00205-2 |
| format | Article |
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2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as
Aristolochia debilis,
Cinnamomum cassia,
Cinnamomum loureirii,
Curcuma zedoaria,
Eugenia caryophyllata,
Pterocarpus santalius,
Rehmania glutinosa and
Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 μg/ml). In addition, the extracts of
A. debilis,
Caesalpinia sappan,
Curcuma longa,
C. zedoaria,
Daphne genkwa and
Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 μg/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(02)00205-2</identifier><identifier>PMID: 12413723</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cyclooxygenase 2 ; Cyclooxygenase-2 (COX-2) ; Dinoprostone - metabolism ; General pharmacology ; Inducible nitric oxide synthase (iNOS) ; Isoenzymes - metabolism ; Korea ; Lipopolysaccharide (LPS) ; Lipopolysaccharides ; Macrophages - drug effects ; Macrophages - metabolism ; Medical sciences ; Medicine, Traditional ; Mice ; Natural products ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - pharmacology ; Plants, Medicinal ; Prostaglandin E 2 ; Prostaglandin-Endoperoxide Synthases - metabolism ; RAW264.7 cells</subject><ispartof>Journal of ethnopharmacology, 2002-11, Vol.83 (1), p.153-159</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-ddc0f115ff3c7dab4afa007b581dde25f367437bca79f38d6d05e4d9e4192ccf3</citedby><cites>FETCH-LOGICAL-c457t-ddc0f115ff3c7dab4afa007b581dde25f367437bca79f38d6d05e4d9e4192ccf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874102002052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13979443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12413723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Chae Hee</creatorcontrib><creatorcontrib>Hur, Sun Kyung</creatorcontrib><creatorcontrib>Oh, O-Jin</creatorcontrib><creatorcontrib>Kim, Sun Sook</creatorcontrib><creatorcontrib>Nam, Kyung Ae</creatorcontrib><creatorcontrib>Lee, Sang Kook</creatorcontrib><title>Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E
2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as
Aristolochia debilis,
Cinnamomum cassia,
Cinnamomum loureirii,
Curcuma zedoaria,
Eugenia caryophyllata,
Pterocarpus santalius,
Rehmania glutinosa and
Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 μg/ml). In addition, the extracts of
A. debilis,
Caesalpinia sappan,
Curcuma longa,
C. zedoaria,
Daphne genkwa and
Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 μg/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclooxygenase 2</subject><subject>Cyclooxygenase-2 (COX-2)</subject><subject>Dinoprostone - metabolism</subject><subject>General pharmacology</subject><subject>Inducible nitric oxide synthase (iNOS)</subject><subject>Isoenzymes - metabolism</subject><subject>Korea</subject><subject>Lipopolysaccharide (LPS)</subject><subject>Lipopolysaccharides</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>Medicine, Traditional</subject><subject>Mice</subject><subject>Natural products</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Prostaglandin E 2</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>RAW264.7 cells</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhEUDegDqLgH_jZIXQqLRIFbMoSOwsx77uGCXOYCdV5z14YDw_0CUrS77fPffcexB6Tcl7Smj94ZZw1VSNEvSCsCUhjMiKPUEL2ihWKan4U7T4h5yhFzn_JIQoKshzdEaZoFwxvkC_L-9NP5spjBGPHkczzcn0eJtGN9sp4_Id4iZ04S8RYimErgdsd7Yfx4fdHUSTAV-s1j8qtsQmOhzDlILF40NwgPMuTpsDEb6ub5dFAdu5L3PA4WGcS2EwNo3bjbkrotD3-SV65k2f4dXpPUffP19-W11XN-urL6tPN5UVUk2Vc5Z4SqX33CpnOmG8KSt2sqHOAZOe10pw1VmjWs8bVzsiQbgWBG2ZtZ6fo3dH3bLurxnypIeQ9w5MhGJMK1ZLIuu6gPIIFp85J_B6m8Jg0k5Tovdx6EMcen9rTZg-xKFZ6XtzGjB3A7jHrtP9C_D2BJhsTe-TiTbkR463qhViz308clDOcR8g6WwDRAsuJLCTdmP4j5U_OrGpsg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Hong, Chae Hee</creator><creator>Hur, Sun Kyung</creator><creator>Oh, O-Jin</creator><creator>Kim, Sun Sook</creator><creator>Nam, Kyung Ae</creator><creator>Lee, Sang Kook</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells</title><author>Hong, Chae Hee ; Hur, Sun Kyung ; Oh, O-Jin ; Kim, Sun Sook ; Nam, Kyung Ae ; Lee, Sang Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-ddc0f115ff3c7dab4afa007b581dde25f367437bca79f38d6d05e4d9e4192ccf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclooxygenase 2</topic><topic>Cyclooxygenase-2 (COX-2)</topic><topic>Dinoprostone - metabolism</topic><topic>General pharmacology</topic><topic>Inducible nitric oxide synthase (iNOS)</topic><topic>Isoenzymes - metabolism</topic><topic>Korea</topic><topic>Lipopolysaccharide (LPS)</topic><topic>Lipopolysaccharides</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>Medicine, Traditional</topic><topic>Mice</topic><topic>Natural products</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Prostaglandin E 2</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>RAW264.7 cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Chae Hee</creatorcontrib><creatorcontrib>Hur, Sun Kyung</creatorcontrib><creatorcontrib>Oh, O-Jin</creatorcontrib><creatorcontrib>Kim, Sun Sook</creatorcontrib><creatorcontrib>Nam, Kyung Ae</creatorcontrib><creatorcontrib>Lee, Sang Kook</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Chae Hee</au><au>Hur, Sun Kyung</au><au>Oh, O-Jin</au><au>Kim, Sun Sook</au><au>Nam, Kyung Ae</au><au>Lee, Sang Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>83</volume><issue>1</issue><spage>153</spage><epage>159</epage><pages>153-159</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E
2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as
Aristolochia debilis,
Cinnamomum cassia,
Cinnamomum loureirii,
Curcuma zedoaria,
Eugenia caryophyllata,
Pterocarpus santalius,
Rehmania glutinosa and
Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 μg/ml). In addition, the extracts of
A. debilis,
Caesalpinia sappan,
Curcuma longa,
C. zedoaria,
Daphne genkwa and
Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 μg/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12413723</pmid><doi>10.1016/S0378-8741(02)00205-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cyclooxygenase 2 Cyclooxygenase-2 (COX-2) Dinoprostone - metabolism General pharmacology Inducible nitric oxide synthase (iNOS) Isoenzymes - metabolism Korea Lipopolysaccharide (LPS) Lipopolysaccharides Macrophages - drug effects Macrophages - metabolism Medical sciences Medicine, Traditional Mice Natural products Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plants, Medicinal Prostaglandin E 2 Prostaglandin-Endoperoxide Synthases - metabolism RAW264.7 cells |
| title | Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells |
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