Identification of an I‐Ad restricted peptide on the 65‐kilodalton heat shock protein of Mycobacterium avium

The 65 kilodalton heat shock protein (Hsp65) from mycobacterial species elicits immune responses and in some cases protective immunity. Here we have used a DNA sublibrary approach to identify antigenic fragments of Mycobacterium avium Hsp65 and a synthetic peptide approach to delineate CD4+ T cell d...

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Veröffentlicht in:	Immunology and cell biology 2002-12, Vol.80 (6), p.574-583
Hauptverfasser:	Nagabhushanam, Vijaya, Purcell, Anthony W, Mannering, Stuart, Germano, Susie, Praszkier, Judyta, Cheers, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Bacterial Proteins CD4-Positive T-Lymphocytes - immunology Chaperonin 60 Chaperonins - genetics Chaperonins - immunology Chaperonins - metabolism Epitopes heat shock protein Histocompatibility Antigens Class II - metabolism Molecular Sequence Data mycobacteria Mycobacterium avium - metabolism Peptides - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T cell clone T cell epitope
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