Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan
We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47, X...
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| Veröffentlicht in: | Internal Medicine 2002, Vol.41(10), pp.842-847 |
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| container_title | Internal Medicine |
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| creator | OTA, Kikuko SUEHIRO, Tadashi IKEDA, Yukio ARII, Kaoru KUMON, Yoshitaka HASHIMOTO, Kozo |
| description | We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47, XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case. (Internal Medicine 41: 842-847, 2002) |
| doi_str_mv | 10.2169/internalmedicine.41.842 |
| format | Article |
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We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47, XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case. 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Med.</addtitle><description>We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47, XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case. (Internal Medicine 41: 842-847, 2002)</description><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Chromosome aberrations</subject><subject>Chromosomes, Human, X</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes Mellitus - therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diagnostic Techniques, Endocrine</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>Insulin - therapeutic use</subject><subject>insulin resistance</subject><subject>Japan</subject><subject>Klinefelter Syndrome - complications</subject><subject>Klinefelter Syndrome - diagnosis</subject><subject>Klinefelter Syndrome - genetics</subject><subject>Klinefelter's syndrome</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sex Chromosome Aberrations</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtvUzEQhS0EoqHwF8AbYHVTv3J9zS4Kr9IipAIrFtbUHlNXN77Bdlr13-MoUSvBZjzSfDPn-BDyirO54L05ialiTjCu0UcXE84Vnw9KPCIzLpXptJCLx2TGDB860coReVbKNWNy0EY8JUdcKC4Z0zPy632ES6xY6Fccx1i3hS5LmVyEip7exnpFz8YmEHBsim8L_X6XfJ7W-I4u6QoK0gvcTLlSSL61NxFvaUz0C2wgPSdPAowFXxzeY_Lz44cfq8_d-bdPp6vleecWRtdODgGkHIRwTC20HxZG9qpn2iM6w73izgdQHFwYfPCDA-yVcALM0AcntJLH5M3-7iZPf7ZYql3H4tp3IOG0LVaLXjW4b6Degy5PpWQMdpPjGvKd5czucrX_5moVty3XtvnyILG9bLOHvUOQDXh9AKA4GEOG5GJ54JRiRsqdhYs9d10q_MZ7AHKNbsT_DHBjxM5EM7ivzc097K4gW0zyLwPJpC4</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>OTA, Kikuko</creator><creator>SUEHIRO, Tadashi</creator><creator>IKEDA, Yukio</creator><creator>ARII, Kaoru</creator><creator>KUMON, Yoshitaka</creator><creator>HASHIMOTO, Kozo</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan</title><author>OTA, Kikuko ; SUEHIRO, Tadashi ; IKEDA, Yukio ; ARII, Kaoru ; KUMON, Yoshitaka ; HASHIMOTO, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c597t-38fa33822c0457d859364607deec91d41cdfa41acf8dfd8cae642c2a986fc2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Chromosome aberrations</topic><topic>Chromosomes, Human, X</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - etiology</topic><topic>Diabetes Mellitus - therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diagnostic Techniques, Endocrine</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Insulin - therapeutic use</topic><topic>insulin resistance</topic><topic>Japan</topic><topic>Klinefelter Syndrome - complications</topic><topic>Klinefelter Syndrome - diagnosis</topic><topic>Klinefelter Syndrome - genetics</topic><topic>Klinefelter's syndrome</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sex Chromosome Aberrations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OTA, Kikuko</creatorcontrib><creatorcontrib>SUEHIRO, Tadashi</creatorcontrib><creatorcontrib>IKEDA, Yukio</creatorcontrib><creatorcontrib>ARII, Kaoru</creatorcontrib><creatorcontrib>KUMON, Yoshitaka</creatorcontrib><creatorcontrib>HASHIMOTO, Kozo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OTA, Kikuko</au><au>SUEHIRO, Tadashi</au><au>IKEDA, Yukio</au><au>ARII, Kaoru</au><au>KUMON, Yoshitaka</au><au>HASHIMOTO, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Associated diseases and complications Biological and medical sciences Blood Glucose Chromosome aberrations Chromosomes, Human, X diabetes mellitus Diabetes Mellitus - etiology Diabetes Mellitus - therapy Diabetes. Impaired glucose tolerance Diagnostic Techniques, Endocrine Endocrine pancreas. Apud cells (diseases) Endocrinopathies Humans Insulin - therapeutic use insulin resistance Japan Klinefelter Syndrome - complications Klinefelter Syndrome - diagnosis Klinefelter Syndrome - genetics Klinefelter's syndrome Male Medical genetics Medical sciences Middle Aged Sex Chromosome Aberrations |
| title | Diabetes Mellitus Associated with Klinefelter's Syndrome: A Case Report and Review in Japan |
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