Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8γ is not essential

Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that interact to form the cytolytic membrane attack complex (MAC) on bacterial cell membranes. It is an oligomeric protein composed of a disulfide-linked C8α–γ heterodimer and a non-covalently associated C8β chain. Previous studi...

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Veröffentlicht in:	Molecular immunology 2002-11, Vol.39 (7), p.453-458
Hauptverfasser:	Parker, Chasta L, Sodetz, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial killing Blood Bactericidal Activity - immunology C8α C8β C8γ Complement Complement C8 - chemistry Complement C8 - physiology Complement Membrane Attack Complex - physiology Gram-Negative Bacteria - immunology Hemolysis Humans Membrane attack complex Protein Subunits
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