Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation
Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs. Two groups were studied: 28 patients (49+/-13 years old) with paroxysmal AF and 20 control patients (49+/-14 years old) without AF. Effective and functional...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-11, Vol.106 (19), p.2479-2485 |
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| creator | JAÏS, Pierre HOCINI, Mélèze LE METAYER, Philippe CLEMENTY, Jacques HAÏSSAGUERRE, Michel MACLE, Laurent CHOI, Kee-Joon DEISENHOFER, Isabel WEERASOORIYA, Rukshen SHAH, Dipen C GARRIGUE, Stéphane RAYBAUD, Florence SCAVEE, Christophe |
| description | Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs.
Two groups were studied: 28 patients (49+/-13 years old) with paroxysmal AF and 20 control patients (49+/-14 years old) without AF. Effective and functional refractory period and conduction time from PV to left atrium (LA) were compared in the 2 groups by use of programmed stimulation with a single extrastimulus in the PVs and LA. In the AF group, the venous effective refractory periods (ERPs) were shorter than that of the LA: 185+/-71 versus 253+/-21 ms, P |
| doi_str_mv | 10.1161/01.CIR.0000036744.39782.9F |
| format | Article |
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Two groups were studied: 28 patients (49+/-13 years old) with paroxysmal AF and 20 control patients (49+/-14 years old) without AF. Effective and functional refractory period and conduction time from PV to left atrium (LA) were compared in the 2 groups by use of programmed stimulation with a single extrastimulus in the PVs and LA. In the AF group, the venous effective refractory periods (ERPs) were shorter than that of the LA: 185+/-71 versus 253+/-21 ms, P<0.001, whereas in the control group, they were longer (282+/-45 versus 253+/-41 ms, P=0.009). The venous ERPs and functional refractory periods in patients with AF were also shorter than that observed in control subjects (185+/-71 versus 282+/-45 ms and 210+/-77 versus 315+/-43 ms, respectively, P<0.001), whereas LA ERPs were not significantly different. Decremental conduction in PVs was more frequent (93% versus 56%, P=0.01) and had a greater increment (102+/-65 versus 42+/-40 ms, P<0.001) in patients with AF. Finally, AF was more frequently induced when pacing was performed in PVs (22 of 90) versus LA (1 of 81) in patients with AF (P<0.001).
The PVs of patients with AF exhibited distinctive electrophysiological properties, which were strikingly different from those of patients devoid of AF, potentially explaining their arrhythmogenicity.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000036744.39782.9F</identifier><identifier>PMID: 12417546</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial - methods ; Cardiology. Vascular system ; Catheter Ablation ; Electrocardiography ; Electrophysiologic Techniques, Cardiac - methods ; Female ; Heart ; Heart Atria - physiopathology ; Heart Conduction System - physiopathology ; Humans ; Male ; Medical sciences ; Middle Aged ; Pulmonary Veins - physiopathology ; Reaction Time</subject><ispartof>Circulation (New York, N.Y.), 2002-11, Vol.106 (19), p.2479-2485</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Nov 5, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-faa72ae204a2cb38781137f7f0c2dedef379a1f51d5170879fe607a45b8b1e543</citedby><cites>FETCH-LOGICAL-c467t-faa72ae204a2cb38781137f7f0c2dedef379a1f51d5170879fe607a45b8b1e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14009024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12417546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAÏS, Pierre</creatorcontrib><creatorcontrib>HOCINI, Mélèze</creatorcontrib><creatorcontrib>LE METAYER, Philippe</creatorcontrib><creatorcontrib>CLEMENTY, Jacques</creatorcontrib><creatorcontrib>HAÏSSAGUERRE, Michel</creatorcontrib><creatorcontrib>MACLE, Laurent</creatorcontrib><creatorcontrib>CHOI, Kee-Joon</creatorcontrib><creatorcontrib>DEISENHOFER, Isabel</creatorcontrib><creatorcontrib>WEERASOORIYA, Rukshen</creatorcontrib><creatorcontrib>SHAH, Dipen C</creatorcontrib><creatorcontrib>GARRIGUE, Stéphane</creatorcontrib><creatorcontrib>RAYBAUD, Florence</creatorcontrib><creatorcontrib>SCAVEE, Christophe</creatorcontrib><title>Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs.
Two groups were studied: 28 patients (49+/-13 years old) with paroxysmal AF and 20 control patients (49+/-14 years old) without AF. Effective and functional refractory period and conduction time from PV to left atrium (LA) were compared in the 2 groups by use of programmed stimulation with a single extrastimulus in the PVs and LA. In the AF group, the venous effective refractory periods (ERPs) were shorter than that of the LA: 185+/-71 versus 253+/-21 ms, P<0.001, whereas in the control group, they were longer (282+/-45 versus 253+/-41 ms, P=0.009). The venous ERPs and functional refractory periods in patients with AF were also shorter than that observed in control subjects (185+/-71 versus 282+/-45 ms and 210+/-77 versus 315+/-43 ms, respectively, P<0.001), whereas LA ERPs were not significantly different. Decremental conduction in PVs was more frequent (93% versus 56%, P=0.01) and had a greater increment (102+/-65 versus 42+/-40 ms, P<0.001) in patients with AF. Finally, AF was more frequently induced when pacing was performed in PVs (22 of 90) versus LA (1 of 81) in patients with AF (P<0.001).
The PVs of patients with AF exhibited distinctive electrophysiological properties, which were strikingly different from those of patients devoid of AF, potentially explaining their arrhythmogenicity.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>Cardiology. Vascular system</subject><subject>Catheter Ablation</subject><subject>Electrocardiography</subject><subject>Electrophysiologic Techniques, Cardiac - methods</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Atria - physiopathology</subject><subject>Heart Conduction System - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Reaction Time</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9rFDEUxYModq1-BQkFfZsx_2Yy45ts3VooCKLPIZO9sSmzyZhkKv323tqFheYlJPd3bm7OIeSCs5bznn9ivN1e_2jZ45K9VqqVox5EO-5ekA3vhGpUJ8eXZIP1sdFSiDPyppQ7PPZSd6_JGReK6071G-IuQ6khuhrugcIMrua03D6UkOb0Ozg70wUvINcAhSZPl3U-pGjzA72HEAsNkS4Wi7EW-jfUW2prDqjyYcphnrGU4lvyytu5wLvjfk5-7b7-3H5rbr5fXW-_3DRO9bo23lotLAimrHCTHPTAudRee-bEHvbgpR4t9x3fd1yzQY8eeqat6qZh4tApeU4-PvXFkf-sUKo5hOIAp4iQ1mK06NWAhiF48Qy8S2uOOJsRXPSD0HJA6PMT5HIqJYM3Sw4H_LnhzDzmYBg3mIM55WD-52DGHYrfH19YpwPsT9Kj8Qh8OAK2oMs-2-hCOXEKo2NCyX-3LJMS</recordid><startdate>20021105</startdate><enddate>20021105</enddate><creator>JAÏS, Pierre</creator><creator>HOCINI, Mélèze</creator><creator>LE METAYER, Philippe</creator><creator>CLEMENTY, Jacques</creator><creator>HAÏSSAGUERRE, Michel</creator><creator>MACLE, Laurent</creator><creator>CHOI, Kee-Joon</creator><creator>DEISENHOFER, Isabel</creator><creator>WEERASOORIYA, Rukshen</creator><creator>SHAH, Dipen C</creator><creator>GARRIGUE, Stéphane</creator><creator>RAYBAUD, Florence</creator><creator>SCAVEE, Christophe</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20021105</creationdate><title>Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation</title><author>JAÏS, Pierre ; HOCINI, Mélèze ; LE METAYER, Philippe ; CLEMENTY, Jacques ; HAÏSSAGUERRE, Michel ; MACLE, Laurent ; CHOI, Kee-Joon ; DEISENHOFER, Isabel ; WEERASOORIYA, Rukshen ; SHAH, Dipen C ; GARRIGUE, Stéphane ; RAYBAUD, Florence ; SCAVEE, Christophe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-faa72ae204a2cb38781137f7f0c2dedef379a1f51d5170879fe607a45b8b1e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial - methods</topic><topic>Cardiology. Vascular system</topic><topic>Catheter Ablation</topic><topic>Electrocardiography</topic><topic>Electrophysiologic Techniques, Cardiac - methods</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Atria - physiopathology</topic><topic>Heart Conduction System - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Reaction Time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAÏS, Pierre</creatorcontrib><creatorcontrib>HOCINI, Mélèze</creatorcontrib><creatorcontrib>LE METAYER, Philippe</creatorcontrib><creatorcontrib>CLEMENTY, Jacques</creatorcontrib><creatorcontrib>HAÏSSAGUERRE, Michel</creatorcontrib><creatorcontrib>MACLE, Laurent</creatorcontrib><creatorcontrib>CHOI, Kee-Joon</creatorcontrib><creatorcontrib>DEISENHOFER, Isabel</creatorcontrib><creatorcontrib>WEERASOORIYA, Rukshen</creatorcontrib><creatorcontrib>SHAH, Dipen C</creatorcontrib><creatorcontrib>GARRIGUE, Stéphane</creatorcontrib><creatorcontrib>RAYBAUD, Florence</creatorcontrib><creatorcontrib>SCAVEE, Christophe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAÏS, Pierre</au><au>HOCINI, Mélèze</au><au>LE METAYER, Philippe</au><au>CLEMENTY, Jacques</au><au>HAÏSSAGUERRE, Michel</au><au>MACLE, Laurent</au><au>CHOI, Kee-Joon</au><au>DEISENHOFER, Isabel</au><au>WEERASOORIYA, Rukshen</au><au>SHAH, Dipen C</au><au>GARRIGUE, Stéphane</au><au>RAYBAUD, Florence</au><au>SCAVEE, Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2002-11-05</date><risdate>2002</risdate><volume>106</volume><issue>19</issue><spage>2479</spage><epage>2485</epage><pages>2479-2485</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs.
Two groups were studied: 28 patients (49+/-13 years old) with paroxysmal AF and 20 control patients (49+/-14 years old) without AF. Effective and functional refractory period and conduction time from PV to left atrium (LA) were compared in the 2 groups by use of programmed stimulation with a single extrastimulus in the PVs and LA. In the AF group, the venous effective refractory periods (ERPs) were shorter than that of the LA: 185+/-71 versus 253+/-21 ms, P<0.001, whereas in the control group, they were longer (282+/-45 versus 253+/-41 ms, P=0.009). The venous ERPs and functional refractory periods in patients with AF were also shorter than that observed in control subjects (185+/-71 versus 282+/-45 ms and 210+/-77 versus 315+/-43 ms, respectively, P<0.001), whereas LA ERPs were not significantly different. Decremental conduction in PVs was more frequent (93% versus 56%, P=0.01) and had a greater increment (102+/-65 versus 42+/-40 ms, P<0.001) in patients with AF. Finally, AF was more frequently induced when pacing was performed in PVs (22 of 90) versus LA (1 of 81) in patients with AF (P<0.001).
The PVs of patients with AF exhibited distinctive electrophysiological properties, which were strikingly different from those of patients devoid of AF, potentially explaining their arrhythmogenicity.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12417546</pmid><doi>10.1161/01.CIR.0000036744.39782.9F</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial - methods Cardiology. Vascular system Catheter Ablation Electrocardiography Electrophysiologic Techniques, Cardiac - methods Female Heart Heart Atria - physiopathology Heart Conduction System - physiopathology Humans Male Medical sciences Middle Aged Pulmonary Veins - physiopathology Reaction Time |
| title | Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation |
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