Central Orexin-A stimulates pancreatic exocrine secretion via the vagus
Digestive organs are controlled from the central nervous system, and the vagus nerve plays an important role. Orexins are recently purified neuropeptides localized in neurons within the lateral hypothalamus. To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion...
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| Veröffentlicht in: | Pancreas 2002-11, Vol.25 (4), p.400-404 |
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| creator | MIYASAKA, Kyoko MASUDA, Masao KANAI, Setsuko SATO, Norikazu KUROSAWA, Mieko FUNAKOSHI, Takihiro |
| description | Digestive organs are controlled from the central nervous system, and the vagus nerve plays an important role. Orexins are recently purified neuropeptides localized in neurons within the lateral hypothalamus.
To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion in conscious rats.
Rats were prepared with cannulae draining bile and pancreatic juice separately. The experiments were conducted without anesthesia on day 4 or 5 after the operation.
Intracerebroventricular administration of Orexin-A (0.25, 0.5, and 1.0 nmol) significantly increased pancreatic fluid and protein output in a dose-dependent manner. A significant stimulatory effect of Orexin-B was not observed. Pretreatment with the ganglion blocker hexamethonium and with atropine completely abolished the stimulatory effect of central Orexin-A. Central Orexin-A significantly increased pancreatic secretion after pretreatment with omeprazole. Intravenous injection of Orexin-A had no effect. Centrally administered Orexin-A stimulated the vagal efferent nerve in anesthetized rats.
Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion. |
| doi_str_mv | 10.1097/00006676-200211000-00013 |
| format | Article |
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To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion in conscious rats.
Rats were prepared with cannulae draining bile and pancreatic juice separately. The experiments were conducted without anesthesia on day 4 or 5 after the operation.
Intracerebroventricular administration of Orexin-A (0.25, 0.5, and 1.0 nmol) significantly increased pancreatic fluid and protein output in a dose-dependent manner. A significant stimulatory effect of Orexin-B was not observed. Pretreatment with the ganglion blocker hexamethonium and with atropine completely abolished the stimulatory effect of central Orexin-A. Central Orexin-A significantly increased pancreatic secretion after pretreatment with omeprazole. Intravenous injection of Orexin-A had no effect. Centrally administered Orexin-A stimulated the vagal efferent nerve in anesthetized rats.
Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-200211000-00013</identifier><identifier>PMID: 12409836</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Atropine - pharmacology ; Biological and medical sciences ; Carrier Proteins - administration & dosage ; Carrier Proteins - antagonists & inhibitors ; Carrier Proteins - pharmacology ; Exocrine pancreas ; Fundamental and applied biological sciences. Psychology ; Ganglionic Blockers - pharmacology ; Hexamethonium - pharmacology ; Injections, Intravenous ; Injections, Intraventricular ; Intracellular Signaling Peptides and Proteins ; Kinetics ; Male ; Neuropeptides - administration & dosage ; Neuropeptides - antagonists & inhibitors ; Neuropeptides - pharmacology ; Omeprazole - pharmacology ; Orexins ; Pancreas - innervation ; Pancreas - metabolism ; Rats ; Rats, Wistar ; Vagus Nerve - drug effects ; Vagus Nerve - physiology ; Vertebrates: digestive system</subject><ispartof>Pancreas, 2002-11, Vol.25 (4), p.400-404</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-12a424d8297960577317dee63b288e7a03e85bda35000233d639c53254f1b0253</citedby><cites>FETCH-LOGICAL-c370t-12a424d8297960577317dee63b288e7a03e85bda35000233d639c53254f1b0253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14007454$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12409836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIYASAKA, Kyoko</creatorcontrib><creatorcontrib>MASUDA, Masao</creatorcontrib><creatorcontrib>KANAI, Setsuko</creatorcontrib><creatorcontrib>SATO, Norikazu</creatorcontrib><creatorcontrib>KUROSAWA, Mieko</creatorcontrib><creatorcontrib>FUNAKOSHI, Takihiro</creatorcontrib><title>Central Orexin-A stimulates pancreatic exocrine secretion via the vagus</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>Digestive organs are controlled from the central nervous system, and the vagus nerve plays an important role. Orexins are recently purified neuropeptides localized in neurons within the lateral hypothalamus.
To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion in conscious rats.
Rats were prepared with cannulae draining bile and pancreatic juice separately. The experiments were conducted without anesthesia on day 4 or 5 after the operation.
Intracerebroventricular administration of Orexin-A (0.25, 0.5, and 1.0 nmol) significantly increased pancreatic fluid and protein output in a dose-dependent manner. A significant stimulatory effect of Orexin-B was not observed. Pretreatment with the ganglion blocker hexamethonium and with atropine completely abolished the stimulatory effect of central Orexin-A. Central Orexin-A significantly increased pancreatic secretion after pretreatment with omeprazole. Intravenous injection of Orexin-A had no effect. Centrally administered Orexin-A stimulated the vagal efferent nerve in anesthetized rats.
Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - administration & dosage</subject><subject>Carrier Proteins - antagonists & inhibitors</subject><subject>Carrier Proteins - pharmacology</subject><subject>Exocrine pancreas</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglionic Blockers - pharmacology</subject><subject>Hexamethonium - pharmacology</subject><subject>Injections, Intravenous</subject><subject>Injections, Intraventricular</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Kinetics</subject><subject>Male</subject><subject>Neuropeptides - administration & dosage</subject><subject>Neuropeptides - antagonists & inhibitors</subject><subject>Neuropeptides - pharmacology</subject><subject>Omeprazole - pharmacology</subject><subject>Orexins</subject><subject>Pancreas - innervation</subject><subject>Pancreas - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - physiology</subject><subject>Vertebrates: digestive system</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtLwzAUgIMobk7_guRF36q5J30cQ6cw2Is-h7Q91UjXzqQd89-buaqBEE74zu1DCFNyR0mu70k6SmmVMUIYpSnK0qX8BE2p5CoThplTNCXGyIxTrSfoIsaPRGgu83M0oUyQ3HA1RcsFtH1wDV4H2Ps2m-PY-83QuB4i3rq2DOB6X2LYd2XwLeAI6av3XYt33uH-HfDOvQ3xEp3VrolwNb4z9Pr48LJ4ylbr5fNivspKrkmfUeYEE5Vhuc4VkVqn6SoAxQtmDGhHOBhZVI7LtA_jvFI8LyVnUtS0IEzyGbo91t2G7nOA2NuNjyU0jWuhG6LVTAmt8gNojmAZuhgD1HYb_MaFL0uJPUi0vxLtn0T7IzGlXo89hmID1X_iaC0BNyPgYumaOiRPPv5zghAtpODfYxV34A</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>MIYASAKA, Kyoko</creator><creator>MASUDA, Masao</creator><creator>KANAI, Setsuko</creator><creator>SATO, Norikazu</creator><creator>KUROSAWA, Mieko</creator><creator>FUNAKOSHI, Takihiro</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Central Orexin-A stimulates pancreatic exocrine secretion via the vagus</title><author>MIYASAKA, Kyoko ; MASUDA, Masao ; KANAI, Setsuko ; SATO, Norikazu ; KUROSAWA, Mieko ; FUNAKOSHI, Takihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-12a424d8297960577317dee63b288e7a03e85bda35000233d639c53254f1b0253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - administration & dosage</topic><topic>Carrier Proteins - antagonists & inhibitors</topic><topic>Carrier Proteins - pharmacology</topic><topic>Exocrine pancreas</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglionic Blockers - pharmacology</topic><topic>Hexamethonium - pharmacology</topic><topic>Injections, Intravenous</topic><topic>Injections, Intraventricular</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Kinetics</topic><topic>Male</topic><topic>Neuropeptides - administration & dosage</topic><topic>Neuropeptides - antagonists & inhibitors</topic><topic>Neuropeptides - pharmacology</topic><topic>Omeprazole - pharmacology</topic><topic>Orexins</topic><topic>Pancreas - innervation</topic><topic>Pancreas - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vagus Nerve - drug effects</topic><topic>Vagus Nerve - physiology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIYASAKA, Kyoko</creatorcontrib><creatorcontrib>MASUDA, Masao</creatorcontrib><creatorcontrib>KANAI, Setsuko</creatorcontrib><creatorcontrib>SATO, Norikazu</creatorcontrib><creatorcontrib>KUROSAWA, Mieko</creatorcontrib><creatorcontrib>FUNAKOSHI, Takihiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIYASAKA, Kyoko</au><au>MASUDA, Masao</au><au>KANAI, Setsuko</au><au>SATO, Norikazu</au><au>KUROSAWA, Mieko</au><au>FUNAKOSHI, Takihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Orexin-A stimulates pancreatic exocrine secretion via the vagus</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>25</volume><issue>4</issue><spage>400</spage><epage>404</epage><pages>400-404</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>Digestive organs are controlled from the central nervous system, and the vagus nerve plays an important role. Orexins are recently purified neuropeptides localized in neurons within the lateral hypothalamus.
To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion in conscious rats.
Rats were prepared with cannulae draining bile and pancreatic juice separately. The experiments were conducted without anesthesia on day 4 or 5 after the operation.
Intracerebroventricular administration of Orexin-A (0.25, 0.5, and 1.0 nmol) significantly increased pancreatic fluid and protein output in a dose-dependent manner. A significant stimulatory effect of Orexin-B was not observed. Pretreatment with the ganglion blocker hexamethonium and with atropine completely abolished the stimulatory effect of central Orexin-A. Central Orexin-A significantly increased pancreatic secretion after pretreatment with omeprazole. Intravenous injection of Orexin-A had no effect. Centrally administered Orexin-A stimulated the vagal efferent nerve in anesthetized rats.
Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12409836</pmid><doi>10.1097/00006676-200211000-00013</doi><tpages>5</tpages></addata></record> |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Atropine - pharmacology Biological and medical sciences Carrier Proteins - administration & dosage Carrier Proteins - antagonists & inhibitors Carrier Proteins - pharmacology Exocrine pancreas Fundamental and applied biological sciences. Psychology Ganglionic Blockers - pharmacology Hexamethonium - pharmacology Injections, Intravenous Injections, Intraventricular Intracellular Signaling Peptides and Proteins Kinetics Male Neuropeptides - administration & dosage Neuropeptides - antagonists & inhibitors Neuropeptides - pharmacology Omeprazole - pharmacology Orexins Pancreas - innervation Pancreas - metabolism Rats Rats, Wistar Vagus Nerve - drug effects Vagus Nerve - physiology Vertebrates: digestive system |
| title | Central Orexin-A stimulates pancreatic exocrine secretion via the vagus |
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