Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
To determine the kinetics of reduction in human cytomegalovirus (HCMV) load and specific anti-glycoprotein B (gB) immune responses in patients with concurrent HCMV DNAaemia following the initiation of highly active antiretroviral therapy (HAART). Sequential analysis of eleven patients with HCMV DNAa...
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| Veröffentlicht in: | AIDS (London) 2002-11, Vol.16 (16), p.2129-2135 |
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| container_title | AIDS (London) |
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| creator | DEAYTON, Jane R SABIN, Caroline A BRITT, William B JONES, Ian M WILSON, Pauline JOHNSON, Margaret A GRIFFITHS, Paul D EMERY, Vincent C |
| description | To determine the kinetics of reduction in human cytomegalovirus (HCMV) load and specific anti-glycoprotein B (gB) immune responses in patients with concurrent HCMV DNAaemia following the initiation of highly active antiretroviral therapy (HAART).
Sequential analysis of eleven patients with HCMV DNAaemia who received HAART and eleven control patients with HCMV DNAaemia.
HCMV load was measured by quantitative competitive polymerase chain reaction and anti-gB, anti-HIV Env and Gag responses by an end-point dilution immunofluorescence assay using recombinant antigens expressed in insect cells. Estimates of the efficacy of the reconstituting immune system at controlling HCMV replication were based on previous dynamic models.
In patients initiating HAART, HCMV DNA levels in blood declined rapidly, with a median half-life of 5.2 days, consistent with an efficacy of the reconstituting immune system at inhibiting HCMV replication of 52.8-85% (median, 61%). Commensurate with this decrease, a significant increase in anti-gB titres was observed in the post-HAART period (corresponding to an average fourfold increase in titre by 1 month rising to an eightfold increase at month 3; = 0.01). No changes in titre were observed in the control group or for anti-HIV Gag antibody levels, while anti-HIV Env antibody levels decreased after HAART.
In patients with HCMV DNAaemia, reconstitution of humoral immunity to HCMV gB occurs rapidly following the initiation of HAART. These changes contrast with the patterns observed for anti-HIV humoral immune responses. |
| doi_str_mv | 10.1097/00002030-200211080-00004 |
| format | Article |
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Sequential analysis of eleven patients with HCMV DNAaemia who received HAART and eleven control patients with HCMV DNAaemia.
HCMV load was measured by quantitative competitive polymerase chain reaction and anti-gB, anti-HIV Env and Gag responses by an end-point dilution immunofluorescence assay using recombinant antigens expressed in insect cells. Estimates of the efficacy of the reconstituting immune system at controlling HCMV replication were based on previous dynamic models.
In patients initiating HAART, HCMV DNA levels in blood declined rapidly, with a median half-life of 5.2 days, consistent with an efficacy of the reconstituting immune system at inhibiting HCMV replication of 52.8-85% (median, 61%). Commensurate with this decrease, a significant increase in anti-gB titres was observed in the post-HAART period (corresponding to an average fourfold increase in titre by 1 month rising to an eightfold increase at month 3; = 0.01). No changes in titre were observed in the control group or for anti-HIV Gag antibody levels, while anti-HIV Env antibody levels decreased after HAART.
In patients with HCMV DNAaemia, reconstitution of humoral immunity to HCMV gB occurs rapidly following the initiation of HAART. These changes contrast with the patterns observed for anti-HIV humoral immune responses.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200211080-00004</identifier><identifier>PMID: 12409733</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - immunology ; AIDS-Related Opportunistic Infections - complications ; AIDS-Related Opportunistic Infections - immunology ; AIDS/HIV ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies, Viral - immunology ; Antibody Formation - immunology ; Antiretroviral Therapy, Highly Active ; Antiviral agents ; Biological and medical sciences ; Cytomegalovirus - physiology ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - immunology ; DNA, Viral - blood ; Female ; Gene Products, env - analysis ; Gene Products, env - immunology ; Gene Products, gag - analysis ; Gene Products, gag - immunology ; HIV-1 - immunology ; HIV-1 - physiology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Pharmacology. Drug treatments ; RNA, Viral - blood ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Envelope Proteins - immunology ; Viral Load ; Virus Replication - drug effects</subject><ispartof>AIDS (London), 2002-11, Vol.16 (16), p.2129-2135</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-6e49faaf781796234897544180ce7a62b8a06acd38c215365f4596f6a4405e4b3</citedby><cites>FETCH-LOGICAL-c422t-6e49faaf781796234897544180ce7a62b8a06acd38c215365f4596f6a4405e4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14402467$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12409733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEAYTON, Jane R</creatorcontrib><creatorcontrib>SABIN, Caroline A</creatorcontrib><creatorcontrib>BRITT, William B</creatorcontrib><creatorcontrib>JONES, Ian M</creatorcontrib><creatorcontrib>WILSON, Pauline</creatorcontrib><creatorcontrib>JOHNSON, Margaret A</creatorcontrib><creatorcontrib>GRIFFITHS, Paul D</creatorcontrib><creatorcontrib>EMERY, Vincent C</creatorcontrib><title>Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To determine the kinetics of reduction in human cytomegalovirus (HCMV) load and specific anti-glycoprotein B (gB) immune responses in patients with concurrent HCMV DNAaemia following the initiation of highly active antiretroviral therapy (HAART).
Sequential analysis of eleven patients with HCMV DNAaemia who received HAART and eleven control patients with HCMV DNAaemia.
HCMV load was measured by quantitative competitive polymerase chain reaction and anti-gB, anti-HIV Env and Gag responses by an end-point dilution immunofluorescence assay using recombinant antigens expressed in insect cells. Estimates of the efficacy of the reconstituting immune system at controlling HCMV replication were based on previous dynamic models.
In patients initiating HAART, HCMV DNA levels in blood declined rapidly, with a median half-life of 5.2 days, consistent with an efficacy of the reconstituting immune system at inhibiting HCMV replication of 52.8-85% (median, 61%). Commensurate with this decrease, a significant increase in anti-gB titres was observed in the post-HAART period (corresponding to an average fourfold increase in titre by 1 month rising to an eightfold increase at month 3; = 0.01). No changes in titre were observed in the control group or for anti-HIV Gag antibody levels, while anti-HIV Env antibody levels decreased after HAART.
In patients with HCMV DNAaemia, reconstitution of humoral immunity to HCMV gB occurs rapidly following the initiation of HAART. These changes contrast with the patterns observed for anti-HIV humoral immune responses.</description><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>AIDS-Related Opportunistic Infections - complications</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS/HIV</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibodies, Viral - immunology</subject><subject>Antibody Formation - immunology</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus - physiology</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>Gene Products, env - analysis</subject><subject>Gene Products, env - immunology</subject><subject>Gene Products, gag - analysis</subject><subject>Gene Products, gag - immunology</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - physiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>RNA, Viral - blood</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Envelope Proteins - immunology</subject><subject>Viral Load</subject><subject>Virus Replication - drug effects</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrGzEUhUVoiJ3HXwjatLtJ9RpJsyyhTQKGQkiyHa5lyVbRjFxJk2L65yMnTrPs3Ry4fOdcLgchTMkVJZ36SuowwknDqlJKNGn2K3GE5lQo3rStop_QnDDZNR1XZIZOc_5ViZZofYJmlIkaw_kc_b2HrV_hZE0cc_FlKj6OODq8mYaYIGA_DNPoyw7DGnxFsNmVONg1hPjs05Txcip4jAXf3j1hF0OIf_y4xhu_3oRqMsU_Wwxj8cmWtLfUzLKxCba7c3TsIGR7cdAz9Pjj-8P1bbP4eXN3_W3RGMFYaaQVnQNwSlPVScaF7lQrBNXEWAWSLTUQCWbFtWG05bJ1ou2kkyAEaa1Y8jP05S13m-LvyebSDz4bGwKMNk65V0wKqRn7L0i15Ix2vIL6DTQp5pys67fJD5B2PSX9vqH-vaH-X0OvK1Gtl4cb03Kwqw_joZIKfD4AkA0El2A0Pn9w9SsmpOIvqWWaog</recordid><startdate>20021108</startdate><enddate>20021108</enddate><creator>DEAYTON, Jane R</creator><creator>SABIN, Caroline A</creator><creator>BRITT, William B</creator><creator>JONES, Ian M</creator><creator>WILSON, Pauline</creator><creator>JOHNSON, Margaret A</creator><creator>GRIFFITHS, Paul D</creator><creator>EMERY, Vincent C</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021108</creationdate><title>Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy</title><author>DEAYTON, Jane R ; SABIN, Caroline A ; BRITT, William B ; JONES, Ian M ; WILSON, Pauline ; JOHNSON, Margaret A ; GRIFFITHS, Paul D ; EMERY, Vincent C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-6e49faaf781796234897544180ce7a62b8a06acd38c215365f4596f6a4405e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>AIDS-Related Opportunistic Infections - complications</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS/HIV</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antibodies, Viral - immunology</topic><topic>Antibody Formation - immunology</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus - physiology</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>Gene Products, env - analysis</topic><topic>Gene Products, env - immunology</topic><topic>Gene Products, gag - analysis</topic><topic>Gene Products, gag - immunology</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 - physiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>RNA, Viral - blood</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Viral Load</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEAYTON, Jane R</creatorcontrib><creatorcontrib>SABIN, Caroline A</creatorcontrib><creatorcontrib>BRITT, William B</creatorcontrib><creatorcontrib>JONES, Ian M</creatorcontrib><creatorcontrib>WILSON, Pauline</creatorcontrib><creatorcontrib>JOHNSON, Margaret A</creatorcontrib><creatorcontrib>GRIFFITHS, Paul D</creatorcontrib><creatorcontrib>EMERY, Vincent C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEAYTON, Jane R</au><au>SABIN, Caroline A</au><au>BRITT, William B</au><au>JONES, Ian M</au><au>WILSON, Pauline</au><au>JOHNSON, Margaret A</au><au>GRIFFITHS, Paul D</au><au>EMERY, Vincent C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2002-11-08</date><risdate>2002</risdate><volume>16</volume><issue>16</issue><spage>2129</spage><epage>2135</epage><pages>2129-2135</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To determine the kinetics of reduction in human cytomegalovirus (HCMV) load and specific anti-glycoprotein B (gB) immune responses in patients with concurrent HCMV DNAaemia following the initiation of highly active antiretroviral therapy (HAART).
Sequential analysis of eleven patients with HCMV DNAaemia who received HAART and eleven control patients with HCMV DNAaemia.
HCMV load was measured by quantitative competitive polymerase chain reaction and anti-gB, anti-HIV Env and Gag responses by an end-point dilution immunofluorescence assay using recombinant antigens expressed in insect cells. Estimates of the efficacy of the reconstituting immune system at controlling HCMV replication were based on previous dynamic models.
In patients initiating HAART, HCMV DNA levels in blood declined rapidly, with a median half-life of 5.2 days, consistent with an efficacy of the reconstituting immune system at inhibiting HCMV replication of 52.8-85% (median, 61%). Commensurate with this decrease, a significant increase in anti-gB titres was observed in the post-HAART period (corresponding to an average fourfold increase in titre by 1 month rising to an eightfold increase at month 3; = 0.01). No changes in titre were observed in the control group or for anti-HIV Gag antibody levels, while anti-HIV Env antibody levels decreased after HAART.
In patients with HCMV DNAaemia, reconstitution of humoral immunity to HCMV gB occurs rapidly following the initiation of HAART. These changes contrast with the patterns observed for anti-HIV humoral immune responses.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12409733</pmid><doi>10.1097/00002030-200211080-00004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2002-11, Vol.16 (16), p.2129-2135 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology AIDS-Related Opportunistic Infections - complications AIDS-Related Opportunistic Infections - immunology AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Viral - immunology Antibody Formation - immunology Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences Cytomegalovirus - physiology Cytomegalovirus Infections - complications Cytomegalovirus Infections - immunology DNA, Viral - blood Female Gene Products, env - analysis Gene Products, env - immunology Gene Products, gag - analysis Gene Products, gag - immunology HIV-1 - immunology HIV-1 - physiology Human viral diseases Humans Infectious diseases Male Medical sciences Pharmacology. Drug treatments RNA, Viral - blood Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Envelope Proteins - immunology Viral Load Virus Replication - drug effects |
| title | Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy |
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