Human Chorionic Gonadotropin (HCG) Activates Monocytes to Produce Interleukin-8 via a Different Pathway from Luteinizing Hormone/HCG Receptor System

To investigate immune-endocrine interactions between the embryo and the mother early in pregnancy, we examined the effects of human chorionic gonadotropin (HCG) on IL-8 production by peripheral blood mononuclear cells (PBMC). Recombinant HCG promoted IL-8 secretion by PBMC derived from nonpregnant w...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2002-11, Vol.87 (11), p.5199-5208
Hauptverfasser:	Kosaka, Kenzo, Fujiwara, Hiroshi, Tatsumi, Keiji, Yoshioka, Shinya, Sato, Yukiyasu, Egawa, Haruto, Higuchi, Toshihiro, Nakayama, Takahiro, Ueda, Masamichi, Maeda, Michiyuki, Fujii, Shingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Nucleus - metabolism Cells, Cultured Chorionic Gonadotropin - metabolism Chorionic Gonadotropin - pharmacology Cysteine Endopeptidases Cysteine Proteinase Inhibitors - pharmacology Female Fluorescein-5-isothiocyanate Fluorescent Dyes Gene Expression - drug effects Gestational Age Granulosa Cells - chemistry Granulosa Cells - drug effects Granulosa Cells - metabolism Humans Interleukin-8 - biosynthesis Interleukin-8 - genetics Interleukin-8 - secretion Kinetics Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - ultrastructure Leupeptins - pharmacology Lipopolysaccharide Receptors - analysis Mannose - pharmacology Multienzyme Complexes - antagonists & inhibitors NF-kappa B - metabolism Pregnancy Progesterone - biosynthesis Proteasome Endopeptidase Complex Receptors, LH - analysis Recombinant Proteins - metabolism Recombinant Proteins - pharmacology RNA, Messenger - biosynthesis
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