Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms

Mutations within the 5′-non-coding region of the bcl-6 gene can occur in lymphomas that originate from germinal centers (GCs), as well as in normal memory and GC B cells. Mutations in the p53 gene occur in 50% of human cancers. Since both bcl-6 and p53 can be mutated in certain circumstances, we inv...

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Veröffentlicht in:	Molecular immunology 2002-11, Vol.39 (7), p.485-493
Hauptverfasser:	Yavuz, Akif S, Monson, Nancy L, Yavuz, Sule, Grammer, Amrie C, Longo, Nancy, Girschick, Hermann J, Lipsky, Peter E
Format:	Artikel
Sprache:	eng
Schlagworte:	B lymphocytes B-Lymphocytes - metabolism Child DNA-Binding Proteins - genetics Genes, Immunoglobulin Genes, p53 Human Humans Mutation - genetics Oncogenes Palatine Tonsil - immunology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-6 T lymphocytes Transcription Factors - genetics
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