Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow

Using a perfusion chamber and confocal laser scanning microscopy, we analyzed the interplay of von Willebrand factor (VWF) and fibrinogen during thrombus growth on a collagen surface under physiologic high shear rate conditions. During initial thrombogenesis, platelet thrombi were constructed totall...

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Veröffentlicht in:	Blood 2002-11, Vol.100 (10), p.3604-3610
Hauptverfasser:	Matsui, Hideto, Sugimoto, Mitsuhiko, Mizuno, Tomohiro, Tsuji, Shizuko, Miyata, Shigeki, Matsuda, Michio, Yoshioka, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Afibrinogenemia - blood Biological and medical sciences Blood coagulation. Blood cells Case-Control Studies Collagen Fibrinogen - metabolism Fibrinogen - physiology Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Heart Diseases - etiology Heart Diseases - metabolism Humans Kinetics Microscopy, Video Molecular and cellular biology Perfusion Platelet Adhesiveness Stress, Mechanical Thrombosis - etiology Thrombosis - metabolism von Willebrand Diseases - blood von Willebrand Factor - metabolism von Willebrand Factor - physiology
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