Individual Hymenoptera Venom Compounds Induce Upregulation of the Basophil Activation Marker Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (CD203c) in Sensitized Patients
Background: Bee and wasp venom extracts contain potent allergens capable of inducing severe clinical reactions. To analyze immediate-type hypersensitivity to defined hymenoptera venom components, a recently developed in vitro test was applied that is based on the upregulation of CD203c expression on...
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| Veröffentlicht in: | International archives of allergy and immunology 2002-10, Vol.129 (2), p.160-168 |
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| creator | Binder, Marc Fierlbeck, Gerhard King, Te Piao Valent, Peter Bühring, Hans-Jörg |
| description | Background: Bee and wasp venom extracts contain potent allergens capable of inducing severe clinical reactions. To analyze immediate-type hypersensitivity to defined hymenoptera venom components, a recently developed in vitro test was applied that is based on the upregulation of CD203c expression on basophils. Methods: CD203c expression on blood basophils of 9 healthy donors and 39 patients allergic to bee and/or wasp venom was analyzed by flow cytometry before and after activation with the purified bee venom allergens phospholipase A 2 (Api m 1), hyaluronidase (Api m 2) and melittin (Api m 4), or the purified wasp venom allergens phospholipase A 1 (Ves v 1), hyaluronidase (Ves v 2) and the recombinant antigen 5 (Ves v 5). Venom-induced CD203c upregulation on basophils was compared with skin tests and assessment of specific IgE. Basophils of nonresponders were preincubated with 10 ng/ml interleukin-3 (IL-3) prior to allergen stimulation. Results: CD203c upregulation on basophils was induced by defined hymenoptera venom components in 35/39 patients with a diagnosed allergy to wasp and/or bee venom. Twenty-seven of the 34 tested patients with wasp allergy showed CD203c upregulation in response to Ves v 5, 26 of these patients also reacted with Ves v 2 and 17 with Ves v 1. Nine of 13 patients with bee allergy reacted with Api m 1, 13 individuals with Api m 2 and none of these patients with the minor allergen Api m 4. A diagnosed wasp allergy could also be confirmed in the prestimulated basophils (IL-3) of 2 nonresponder individuals who failed to upregulate CD203c in response to IgE receptor cross-linking prior to culture with IL-3. Conclusions: Flow-cytometric determination of CD203c upregulation on basophils activated by molecularly defined allergens is a powerful method to identify the precise allergen reactivity in sensitized individuals. |
| doi_str_mv | 10.1159/000065875 |
| format | Article |
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To analyze immediate-type hypersensitivity to defined hymenoptera venom components, a recently developed in vitro test was applied that is based on the upregulation of CD203c expression on basophils. Methods: CD203c expression on blood basophils of 9 healthy donors and 39 patients allergic to bee and/or wasp venom was analyzed by flow cytometry before and after activation with the purified bee venom allergens phospholipase A 2 (Api m 1), hyaluronidase (Api m 2) and melittin (Api m 4), or the purified wasp venom allergens phospholipase A 1 (Ves v 1), hyaluronidase (Ves v 2) and the recombinant antigen 5 (Ves v 5). Venom-induced CD203c upregulation on basophils was compared with skin tests and assessment of specific IgE. Basophils of nonresponders were preincubated with 10 ng/ml interleukin-3 (IL-3) prior to allergen stimulation. Results: CD203c upregulation on basophils was induced by defined hymenoptera venom components in 35/39 patients with a diagnosed allergy to wasp and/or bee venom. Twenty-seven of the 34 tested patients with wasp allergy showed CD203c upregulation in response to Ves v 5, 26 of these patients also reacted with Ves v 2 and 17 with Ves v 1. Nine of 13 patients with bee allergy reacted with Api m 1, 13 individuals with Api m 2 and none of these patients with the minor allergen Api m 4. A diagnosed wasp allergy could also be confirmed in the prestimulated basophils (IL-3) of 2 nonresponder individuals who failed to upregulate CD203c in response to IgE receptor cross-linking prior to culture with IL-3. Conclusions: Flow-cytometric determination of CD203c upregulation on basophils activated by molecularly defined allergens is a powerful method to identify the precise allergen reactivity in sensitized individuals.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000065875</identifier><identifier>PMID: 12403934</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Adult ; Aged ; Allergens - immunology ; Allergic diseases ; Animals ; Basophils - immunology ; Bee Venoms - immunology ; Bees - immunology ; Biological and medical sciences ; Child ; Female ; Flow Cytometry ; Humans ; Hypersensitivity - diagnosis ; Hypersensitivity - immunology ; Immunoglobulin E - immunology ; Immunopathology ; Interleukin-3 - immunology ; Male ; Medical sciences ; Middle Aged ; Original Paper ; Phosphoric Diester Hydrolases - biosynthesis ; Phosphoric Diester Hydrolases - immunology ; Pyrophosphatases - biosynthesis ; Pyrophosphatases - immunology ; Skin allergic diseases. Stinging insect allergies ; Up-Regulation - immunology ; Wasp Venoms - immunology ; Wasps - immunology</subject><ispartof>International archives of allergy and immunology, 2002-10, Vol.129 (2), p.160-168</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright (c) 2002 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-e2e6725d1be3ac1201da3e367875080a8e31590753ab1890c2a1a3a7072ead513</citedby><cites>FETCH-LOGICAL-c482t-e2e6725d1be3ac1201da3e367875080a8e31590753ab1890c2a1a3a7072ead513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13993905$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12403934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binder, Marc</creatorcontrib><creatorcontrib>Fierlbeck, Gerhard</creatorcontrib><creatorcontrib>King, Te Piao</creatorcontrib><creatorcontrib>Valent, Peter</creatorcontrib><creatorcontrib>Bühring, Hans-Jörg</creatorcontrib><title>Individual Hymenoptera Venom Compounds Induce Upregulation of the Basophil Activation Marker Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (CD203c) in Sensitized Patients</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: Bee and wasp venom extracts contain potent allergens capable of inducing severe clinical reactions. To analyze immediate-type hypersensitivity to defined hymenoptera venom components, a recently developed in vitro test was applied that is based on the upregulation of CD203c expression on basophils. Methods: CD203c expression on blood basophils of 9 healthy donors and 39 patients allergic to bee and/or wasp venom was analyzed by flow cytometry before and after activation with the purified bee venom allergens phospholipase A 2 (Api m 1), hyaluronidase (Api m 2) and melittin (Api m 4), or the purified wasp venom allergens phospholipase A 1 (Ves v 1), hyaluronidase (Ves v 2) and the recombinant antigen 5 (Ves v 5). Venom-induced CD203c upregulation on basophils was compared with skin tests and assessment of specific IgE. Basophils of nonresponders were preincubated with 10 ng/ml interleukin-3 (IL-3) prior to allergen stimulation. Results: CD203c upregulation on basophils was induced by defined hymenoptera venom components in 35/39 patients with a diagnosed allergy to wasp and/or bee venom. Twenty-seven of the 34 tested patients with wasp allergy showed CD203c upregulation in response to Ves v 5, 26 of these patients also reacted with Ves v 2 and 17 with Ves v 1. Nine of 13 patients with bee allergy reacted with Api m 1, 13 individuals with Api m 2 and none of these patients with the minor allergen Api m 4. A diagnosed wasp allergy could also be confirmed in the prestimulated basophils (IL-3) of 2 nonresponder individuals who failed to upregulate CD203c in response to IgE receptor cross-linking prior to culture with IL-3. Conclusions: Flow-cytometric determination of CD203c upregulation on basophils activated by molecularly defined allergens is a powerful method to identify the precise allergen reactivity in sensitized individuals.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Basophils - immunology</subject><subject>Bee Venoms - immunology</subject><subject>Bees - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Hypersensitivity - diagnosis</subject><subject>Hypersensitivity - immunology</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Interleukin-3 - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Phosphoric Diester Hydrolases - biosynthesis</subject><subject>Phosphoric Diester Hydrolases - immunology</subject><subject>Pyrophosphatases - biosynthesis</subject><subject>Pyrophosphatases - immunology</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Up-Regulation - immunology</subject><subject>Wasp Venoms - immunology</subject><subject>Wasps - immunology</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0V9rFDEQAPBFFFtPH3wWJBQU-7A2f3Yvu4_nWe1BxQOtr8tcMttLu5tsk2zh_FJ-RXO9swURzEsG5sdkMpNlLxl9z1hZn9B0pmUly0fZISu4yCmt5eMUU1blvBDVQfYshCtKE66mT7MDxgsqalEcZr8WVptbo0foyNmmR-uGiB7IjxT1ZO76wY1WB5LYqJBcDB4vxw6icZa4lsQ1kg8Q3LA2HZmpaG53qS_gr9GTUxWdHVWHLhqNZLnxSbowrCFCwJPlXey0wbB9NCAR5N38I6dCHRNjyTe0wUTzEzVZprpoY3iePWmhC_hif0-yi0-n3-dn-fnXz4v57DxXRcVjjhynkpearVCAYpwyDQLFVKYh0YpChSLNgspSwIpVNVUcGAiQVHIEXTIxyd7u6g7e3Yypv6Y3QWHXgUU3hkbyaVGIUv4XskoWNU1LmWRHf8ErN3qbPtHw1J9gtawSOt4h5V0IHttm8KYHv2kYbba7bu53nezrfcFx1aN-kPvlJvBmDyAo6FoPVpnw4ERdi5puC73auWvwl-jvwZ9njv6ZXcxmd6AZdCt-A3EJxrk</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Binder, Marc</creator><creator>Fierlbeck, Gerhard</creator><creator>King, Te Piao</creator><creator>Valent, Peter</creator><creator>Bühring, Hans-Jörg</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Individual Hymenoptera Venom Compounds Induce Upregulation of the Basophil Activation Marker Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (CD203c) in Sensitized Patients</title><author>Binder, Marc ; Fierlbeck, Gerhard ; King, Te Piao ; Valent, Peter ; Bühring, Hans-Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-e2e6725d1be3ac1201da3e367875080a8e31590753ab1890c2a1a3a7072ead513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Basophils - immunology</topic><topic>Bee Venoms - immunology</topic><topic>Bees - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Hypersensitivity - diagnosis</topic><topic>Hypersensitivity - immunology</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Interleukin-3 - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Phosphoric Diester Hydrolases - biosynthesis</topic><topic>Phosphoric Diester Hydrolases - immunology</topic><topic>Pyrophosphatases - biosynthesis</topic><topic>Pyrophosphatases - immunology</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Up-Regulation - immunology</topic><topic>Wasp Venoms - immunology</topic><topic>Wasps - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binder, Marc</creatorcontrib><creatorcontrib>Fierlbeck, Gerhard</creatorcontrib><creatorcontrib>King, Te Piao</creatorcontrib><creatorcontrib>Valent, Peter</creatorcontrib><creatorcontrib>Bühring, Hans-Jörg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International archives of allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binder, Marc</au><au>Fierlbeck, Gerhard</au><au>King, Te Piao</au><au>Valent, Peter</au><au>Bühring, Hans-Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual Hymenoptera Venom Compounds Induce Upregulation of the Basophil Activation Marker Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (CD203c) in Sensitized Patients</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>129</volume><issue>2</issue><spage>160</spage><epage>168</epage><pages>160-168</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>Background: Bee and wasp venom extracts contain potent allergens capable of inducing severe clinical reactions. To analyze immediate-type hypersensitivity to defined hymenoptera venom components, a recently developed in vitro test was applied that is based on the upregulation of CD203c expression on basophils. Methods: CD203c expression on blood basophils of 9 healthy donors and 39 patients allergic to bee and/or wasp venom was analyzed by flow cytometry before and after activation with the purified bee venom allergens phospholipase A 2 (Api m 1), hyaluronidase (Api m 2) and melittin (Api m 4), or the purified wasp venom allergens phospholipase A 1 (Ves v 1), hyaluronidase (Ves v 2) and the recombinant antigen 5 (Ves v 5). Venom-induced CD203c upregulation on basophils was compared with skin tests and assessment of specific IgE. Basophils of nonresponders were preincubated with 10 ng/ml interleukin-3 (IL-3) prior to allergen stimulation. Results: CD203c upregulation on basophils was induced by defined hymenoptera venom components in 35/39 patients with a diagnosed allergy to wasp and/or bee venom. Twenty-seven of the 34 tested patients with wasp allergy showed CD203c upregulation in response to Ves v 5, 26 of these patients also reacted with Ves v 2 and 17 with Ves v 1. Nine of 13 patients with bee allergy reacted with Api m 1, 13 individuals with Api m 2 and none of these patients with the minor allergen Api m 4. A diagnosed wasp allergy could also be confirmed in the prestimulated basophils (IL-3) of 2 nonresponder individuals who failed to upregulate CD203c in response to IgE receptor cross-linking prior to culture with IL-3. Conclusions: Flow-cytometric determination of CD203c upregulation on basophils activated by molecularly defined allergens is a powerful method to identify the precise allergen reactivity in sensitized individuals.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12403934</pmid><doi>10.1159/000065875</doi><tpages>9</tpages></addata></record> |
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| ispartof | International archives of allergy and immunology, 2002-10, Vol.129 (2), p.160-168 |
| issn | 1018-2438 1423-0097 |
| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Allergens - immunology Allergic diseases Animals Basophils - immunology Bee Venoms - immunology Bees - immunology Biological and medical sciences Child Female Flow Cytometry Humans Hypersensitivity - diagnosis Hypersensitivity - immunology Immunoglobulin E - immunology Immunopathology Interleukin-3 - immunology Male Medical sciences Middle Aged Original Paper Phosphoric Diester Hydrolases - biosynthesis Phosphoric Diester Hydrolases - immunology Pyrophosphatases - biosynthesis Pyrophosphatases - immunology Skin allergic diseases. Stinging insect allergies Up-Regulation - immunology Wasp Venoms - immunology Wasps - immunology |
| title | Individual Hymenoptera Venom Compounds Induce Upregulation of the Basophil Activation Marker Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (CD203c) in Sensitized Patients |
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