Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system
The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the cent...
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| Veröffentlicht in: | Regulatory peptides 2002-11, Vol.109 (1), p.49-55 |
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| creator | Szabó, F Horváth, J Heinzlmann, A Arimura, A Köves, K |
| description | The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the central nervous system. In our previous work, it was shown that a single PACAP injection into neonatal female rats delayed puberty. In the present work, neonatal administration of PACAP delayed the vaginal opening and decreased the weight of anterior pituitaries, the number of expelled ova at the first ovulation and the intensity of LHRH immunostaining in the septo–preoptico–infundibular system. PACAP antiserum had a reverse effect on LHRH immunoreactivity. The other studied parameters in the latter group remained unchanged compared to control rats. It was concluded that neonatal PACAP administration delayed the onset of puberty through the influence of the LHRH neuronal system. |
| doi_str_mv | 10.1016/S0167-0115(02)00185-4 |
| format | Article |
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It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the central nervous system. In our previous work, it was shown that a single PACAP injection into neonatal female rats delayed puberty. In the present work, neonatal administration of PACAP delayed the vaginal opening and decreased the weight of anterior pituitaries, the number of expelled ova at the first ovulation and the intensity of LHRH immunostaining in the septo–preoptico–infundibular system. PACAP antiserum had a reverse effect on LHRH immunoreactivity. The other studied parameters in the latter group remained unchanged compared to control rats. It was concluded that neonatal PACAP administration delayed the onset of puberty through the influence of the LHRH neuronal system.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/S0167-0115(02)00185-4</identifier><identifier>PMID: 12409214</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Body Weight - drug effects ; Central Nervous System - drug effects ; Central Nervous System - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - metabolism ; Image analysis ; LHRH immunohistochemistry ; Neuropeptides - pharmacology ; Organ Size - drug effects ; Ovary ; Ovary - drug effects ; Ovulation ; Pituitary ; Pituitary Adenylate Cyclase-Activating Polypeptide ; Pituitary Gland, Anterior - drug effects ; Rats ; Rats, Sprague-Dawley ; Sexual differentiation and maturation. Puberty. Climacterium ; Sexual Maturation - drug effects ; Vagina - drug effects ; Vagina - physiology ; Vertebrates: reproduction</subject><ispartof>Regulatory peptides, 2002-11, Vol.109 (1), p.49-55</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-552a51bb4cf2839b5f238e7a5771e16a2332ada2fede4c103cbe6cccc9bd1c3e3</citedby><cites>FETCH-LOGICAL-c509t-552a51bb4cf2839b5f238e7a5771e16a2332ada2fede4c103cbe6cccc9bd1c3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-0115(02)00185-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13996726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12409214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabó, F</creatorcontrib><creatorcontrib>Horváth, J</creatorcontrib><creatorcontrib>Heinzlmann, A</creatorcontrib><creatorcontrib>Arimura, A</creatorcontrib><creatorcontrib>Köves, K</creatorcontrib><title>Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the central nervous system. In our previous work, it was shown that a single PACAP injection into neonatal female rats delayed puberty. In the present work, neonatal administration of PACAP delayed the vaginal opening and decreased the weight of anterior pituitaries, the number of expelled ova at the first ovulation and the intensity of LHRH immunostaining in the septo–preoptico–infundibular system. PACAP antiserum had a reverse effect on LHRH immunoreactivity. The other studied parameters in the latter group remained unchanged compared to control rats. It was concluded that neonatal PACAP administration delayed the onset of puberty through the influence of the LHRH neuronal system.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Image analysis</subject><subject>LHRH immunohistochemistry</subject><subject>Neuropeptides - pharmacology</subject><subject>Organ Size - drug effects</subject><subject>Ovary</subject><subject>Ovary - drug effects</subject><subject>Ovulation</subject><subject>Pituitary</subject><subject>Pituitary Adenylate Cyclase-Activating Polypeptide</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sexual differentiation and maturation. Puberty. Climacterium</subject><subject>Sexual Maturation - drug effects</subject><subject>Vagina - drug effects</subject><subject>Vagina - physiology</subject><subject>Vertebrates: reproduction</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMoOi6PoOSi6KE1S6eXkwyDOsKg4nIO6XRFI72MSVqYtzezoEdzSIXwVdXPh9AxJZeU0OzqJV55QigV54RdEEILkaRbaESLnCc0K7JtNPpF9tC-958REnnOd9EeZSkpGU1HyDxA36mgGvw0noyfsKpb21kfnAq277DtcHx5XEOjFh7PhwpcWODw4frh_SNWiIhpBug04N6sPmbT5ynuYHBxcIP9wgdoD9GOUY2Ho009QG-3N6-TaTJ7vLufjGeJFqQMiRBMCVpVqTas4GUlDOMF5CrGpkAzxThnqlbMQA2ppoTrCjIdT1nVVHPgB-hsPXfu-q8BfJCt9RqaRnXQD17mLEtZWfIIijWoXe-9AyPnzrbKLSQlcilYrgTLpT1JmFwJlmnsO9ksGKoW6r-ujdEInG4A5bVqjFOdtv6P42WZxRSRu15zEHV8W3DSa7vUWFsHOsi6t_9E-QFbb5io</recordid><startdate>20021115</startdate><enddate>20021115</enddate><creator>Szabó, F</creator><creator>Horváth, J</creator><creator>Heinzlmann, A</creator><creator>Arimura, A</creator><creator>Köves, K</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021115</creationdate><title>Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system</title><author>Szabó, F ; Horváth, J ; Heinzlmann, A ; Arimura, A ; Köves, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-552a51bb4cf2839b5f238e7a5771e16a2332ada2fede4c103cbe6cccc9bd1c3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Image analysis</topic><topic>LHRH immunohistochemistry</topic><topic>Neuropeptides - pharmacology</topic><topic>Organ Size - drug effects</topic><topic>Ovary</topic><topic>Ovary - drug effects</topic><topic>Ovulation</topic><topic>Pituitary</topic><topic>Pituitary Adenylate Cyclase-Activating Polypeptide</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sexual differentiation and maturation. Puberty. Climacterium</topic><topic>Sexual Maturation - drug effects</topic><topic>Vagina - drug effects</topic><topic>Vagina - physiology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabó, F</creatorcontrib><creatorcontrib>Horváth, J</creatorcontrib><creatorcontrib>Heinzlmann, A</creatorcontrib><creatorcontrib>Arimura, A</creatorcontrib><creatorcontrib>Köves, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabó, F</au><au>Horváth, J</au><au>Heinzlmann, A</au><au>Arimura, A</au><au>Köves, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>2002-11-15</date><risdate>2002</risdate><volume>109</volume><issue>1</issue><spage>49</spage><epage>55</epage><pages>49-55</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the central nervous system. In our previous work, it was shown that a single PACAP injection into neonatal female rats delayed puberty. In the present work, neonatal administration of PACAP delayed the vaginal opening and decreased the weight of anterior pituitaries, the number of expelled ova at the first ovulation and the intensity of LHRH immunostaining in the septo–preoptico–infundibular system. PACAP antiserum had a reverse effect on LHRH immunoreactivity. The other studied parameters in the latter group remained unchanged compared to control rats. It was concluded that neonatal PACAP administration delayed the onset of puberty through the influence of the LHRH neuronal system.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12409214</pmid><doi>10.1016/S0167-0115(02)00185-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Biological and medical sciences Body Weight - drug effects Central Nervous System - drug effects Central Nervous System - metabolism Female Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - metabolism Image analysis LHRH immunohistochemistry Neuropeptides - pharmacology Organ Size - drug effects Ovary Ovary - drug effects Ovulation Pituitary Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Gland, Anterior - drug effects Rats Rats, Sprague-Dawley Sexual differentiation and maturation. Puberty. Climacterium Sexual Maturation - drug effects Vagina - drug effects Vagina - physiology Vertebrates: reproduction |
| title | Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system |
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