Lipoxin, leukotriene, and PDGF receptors cross‐talk to regulate mesangial cell proliferation

The lipoxygenase‐derived leukotrienes (LTs) are important proinflammatory lipid mediators. Lipoxins (LXs), more recently described lipoxygenase products, modulate many proinflammatory actions of LTs and have impressive proresolution properties. Mesangial cell (MC) proliferation is a central event in...

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Veröffentlicht in:	The FASEB journal 2002-11, Vol.16 (13), p.1-16
Hauptverfasser:	Mc Mahon, Blaithin, Mitchell, Derick, Shattock, Richard, Martin, Finian, Brady, Hugh R., Godson, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cell Division - physiology Cells, Cultured CHO Cells Cricetinae Dicarboxylic Acids - pharmacology eicosanoids Enzyme Inhibitors - pharmacology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - physiology GPCR Humans Hydroxyeicosatetraenoic Acids - pharmacology Indoles - pharmacology Leukotriene Antagonists - pharmacology Leukotriene D4 - pharmacology Lipoxins Maleimides - pharmacology Phosphorylation - drug effects Protein Kinase C - antagonists & inhibitors Receptor Cross-Talk - physiology Receptors, Cell Surface - physiology Receptors, Leukotriene - physiology Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors Receptors, Platelet-Derived Growth Factor - physiology RTK transactivation Tyrosine - metabolism
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