On the mechanism of substrate specificity by resistance nodulation division (RND)‐type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

Summary Tripartite efflux systems of Gram‐negative bacteria that contain an inner membrane transporter belonging to the resistance nodulation division (RND) superfamily can extrude a large variety of structurally diverse compounds. To gain an insight into the molecular mechanisms of substrate recogn...

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Veröffentlicht in:	Molecular microbiology 2002-11, Vol.46 (3), p.889-901
Hauptverfasser:	Mao, Weimin, Warren, Mark S., Black, Deborah S., Satou, Takahumi, Murata, Takeshi, Nishino, Takeshi, Gotoh, Naomasa, Lomovskaya, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Binding Sites Carbenicillin - metabolism Carbenicillin - pharmacology Drug Resistance, Multiple, Bacterial Lactams - metabolism Lactams - pharmacology Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbial Sensitivity Tests Periplasm Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Substrate Specificity
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