Allogeneic bone marrow transplantation (BMT) for adults with acute lymphoblastic leukemia (ALL): predictive role of minimal residual disease monitoring on relapse

We developed a PCR-based method to monitor clonogenic IgH VDJ rearrangement as a possible predictor of relapse in patients with acute B-ALL after allogeneic bone marrow transplantation (BMT). We studied 23 patients at diagnosis, before and after BMT. At the time of BMT, 13 patients were in first com...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2002-11, Vol.30 (9), p.579-585
Hauptverfasser:	Miglino, M, Berisso, G, Grasso, R, Canepa, L, Clavio, M, Pierri, I, Pietrasanta, D, Gatto, S, Varaldo, R, Ballerini, F, Verdiani, S, Casarino, L, DeStefano, F, Sessarego, M, Dominietto, A, Raiola, A M, Bregante, S, di Grazia, C, Gobbi, M, Bacigalupo, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Adult Bone marrow Bone Marrow Transplantation Female Follow-Up Studies Gene Rearrangement Genes, Immunoglobulin Graft-versus-host reaction Heavy chains Humans Immunoglobulins Leukemia Lymphatic leukemia Lymphocyte Transfusion Lymphocytes Male Minimal residual disease Neoplasm, Residual Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Recurrence Remission Remission (Medicine) Stem cell transplantation Transplantation Transplantation, Homologous Treatment Outcome
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